1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	V	W	L	R	A	G	A	L	V	A	A	V	M	L	S	L	S	G	C	G	G	F	H	A	G	A	P	S	T	A	G	P	C	E	I	V	P	N	G	T	P	A	P	K	T	P	P	A	T	V	P	S	S	R	N	L	A	T
Secondary structure
SS confidence
Disorder		?	?	?	?																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	P	E	I	A	T	G	Y	R	R	D	M	T	V	V	R	T	A	H	Y	A	A	A	T	A	N	P	L	A	T	Q	V	A	C	R	V	L	R	D	G	G	T	A	A	D	A	V	V	A	A	Q	A	V	L	G	L	V	E	P	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	S	G	I	G	G	G	G	Y	L	V	Y	F	D	A	R	T	G	S	V	Q	A	Y	D	G	R	E	V	A	P	A	A	A	T	E	N	Y	L	R	W	V	S	D	V	D	R	S	A	P	R	P	N	A	R	A	S	G	R	S	I
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	V	P	G	I	L	R	M	L	E	M	V	H	N	E	H	G	R	T	P	W	R	D	L	F	G	P	A	V	T	L	A	D	G	G	F	D	I	S	A	R	M	G	A	A	I	S	D	A	A	P	Q	L	R	D	D	P	E	A	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	Y	F	L	N	P	D	G	S	P	K	P	A	G	T	R	L	T	N	P	A	Y	S	K	T	L	S	A	I	A	S	A	G	A	N	A	F	Y	S	G	D	I	A	H	D	I	V	A	A	A	S	D	T	S	N	G	R	T	P	G
Secondary structure
SS confidence
Disorder																																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	L	T	I	E	D	L	A	G	Y	L	A	K	R	R	Q	P	L	C	T	T	Y	R	G	R	E	I	C	G	M	P	S	S	G	G	V	A	V	A	A	T	L	G	I	L	E	H	F	P	M	S	D	Y	A	P	S	K	V	D	L
Secondary structure
SS confidence
Disorder																																																			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		N	G	G	R	P	T	V	M	G	V	H	L	I	A	E	A	E	R	L	A	Y	A	D	R	D	Q	Y	I	A	D	V	D	F	V	R	L	P	G	G	S	L	T	T	L	V	D	P	G	Y	L	A	A	R	A	A	L	I	S	P	Q
Secondary structure
SS confidence
Disorder		?	?																																																							?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		H	S	M	G	S	A	R	P	G	D	F	G	A	P	T	A	V	A	P	P	V	P	E	H	G	T	S	H	L	S	V	V	D	S	Y	G	N	A	A	T	L	T	T	T	V	E	S	S	F	G	S	Y	H	L	V	D	G	F	I	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		N	N	Q	L	S	D	F	S	A	E	P	H	A	T	D	G	S	P	V	A	N	R	V	E	P	G	K	R	P	R	S	S	M	A	P	T	L	V	F	D	H	S	S	A	G	R	G	A	L	Y	A	V	L	G	S	P	G	G	S	M
Secondary structure
SS confidence
Disorder						?								?	?	?	?	?		?										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		I	I	Q	F	V	V	K	T	L	V	A	M	L	D	W	G	L	N	P	Q	Q	A	V	S	L	V	D	F	G	A	A	N	S	P	H	T	N	L	G	G	E	N	P	E	I	N	T	S	D	D	G	D	H	D	P	L	V	Q	G	L
Secondary structure
SS confidence
Disorder																																				?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.
Sequence		R	A	L	G	H	R	V	N	L	A	E	Q	S	S	G	L	S	A	I	T	R	S	E	A	G	W	A	G	G	A	D	P	R	R	E	G	A	V	M	G	D	D	A
Secondary structure
SS confidence
Disorder													?																										?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 35%) Beta strand ( 15%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 4y23 chain A Region: 74 - 640 Aligned: 525 Modelled: 564 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:gamma glutamyl transpeptidase,gamma-glutamyltranspeptidase; PDBTitle: crystal structure of t399a precursor mutant protein of gamma-glutamyl2 transpeptidase from bacillus licheniformis Phyre2 PDB 2nlz chain A domain 1 Region: 61 - 640 Aligned: 515 Modelled: 562 Confidence: 100.0% Identity: 27% Fold: Ntn hydrolase-like Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family: Gamma-glutamyltranspeptidase-like Phyre2 PDB 2i3o chain A domain 1 Region: 70 - 640 Aligned: 494 Modelled: 522 Confidence: 100.0% Identity: 25% Fold: Ntn hydrolase-like Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family: Gamma-glutamyltranspeptidase-like Phyre2 PDB 2e0w chain A Region: 60 - 640 Aligned: 488 Modelled: 535 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:gamma-glutamyltranspeptidase; PDBTitle: t391a precursor mutant protein of gamma-glutamyltranspeptidase from2 escherichia coli Phyre2 PDB 2v36 chain A Region: 67 - 454 Aligned: 357 Modelled: 388 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:gamma-glutamyltranspeptidase large chain; PDBTitle: crystal structure of gamma-glutamyl transferase from bacillus subtilis Phyre2 PDB 2qm6 chain C Region: 76 - 448 Aligned: 344 Modelled: 373 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: C: PDB Molecule:gamma-glutamyltranspeptidase; PDBTitle: crystal structure of helicobacter pylori gamma-glutamyltranspeptidase2 in complex with glutamate Phyre2 PDB 2z8j chain A Region: 72 - 435 Aligned: 343 Modelled: 361 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:gamma-glutamyltranspeptidase; PDBTitle: crystal structure of escherichia coli gamma-glutamyltranspeptidase in2 complex with azaserine prepared in the dark Phyre2 PDB 4gdx chain A Region: 78 - 434 Aligned: 334 Modelled: 352 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:gamma-glutamyltranspeptidase 1 heavy chain; PDBTitle: crystal structure of human gamma-glutamyl transpeptidase--glutamate2 complex Phyre2 PDB 5zjg chain C Region: 77 - 434 Aligned: 331 Modelled: 350 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: C: PDB Molecule:gamma-glutamyltransferase 1 threonine peptidase. merops PDBTitle: gamma-glutamyltranspeptidase from pseudomonas nitroreducens complexed2 with gly-gly Phyre2 PDB 3g9k chain D Region: 78 - 407 Aligned: 276 Modelled: 305 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: D: PDB Molecule:capsule biosynthesis protein capd; PDBTitle: crystal structure of bacillus anthracis transpeptidase enzyme capd Phyre2 PDB 5zjg chain D Region: 446 - 642 Aligned: 186 Modelled: 197 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: D: PDB Molecule:gamma-glutamyltransferase 1 threonine peptidase. merops PDBTitle: gamma-glutamyltranspeptidase from pseudomonas nitroreducens complexed2 with gly-gly Phyre2 PDB 2e0y chain B Region: 446 - 640 Aligned: 175 Modelled: 195 Confidence: 100.0% Identity: 39% PDB header:transferase Chain: B: PDB Molecule:gamma-glutamyltranspeptidase; PDBTitle: crystal structure of the samarium derivative of mature gamma-2 glutamyltranspeptidase from escherichia coli Phyre2 PDB 4gdx chain B Region: 446 - 640 Aligned: 176 Modelled: 195 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: B: PDB Molecule:gamma-glutamyltranspeptidase 1 light chain; PDBTitle: crystal structure of human gamma-glutamyl transpeptidase--glutamate2 complex Phyre2 PDB 2v36 chain D Region: 446 - 640 Aligned: 174 Modelled: 195 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: D: PDB Molecule:gamma-glutamyltranspeptidase small chain; PDBTitle: crystal structure of gamma-glutamyl transferase from bacillus subtilis Phyre2 PDB 2nqo chain B Region: 446 - 634 Aligned: 175 Modelled: 189 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: B: PDB Molecule:gamma-glutamyltranspeptidase; PDBTitle: crystal structure of helicobacter pylori gamma-glutamyltranspeptidase Phyre2 PDB 3ga9 chain S Region: 446 - 642 Aligned: 163 Modelled: 179 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: S: PDB Molecule:capsule biosynthesis protein capd; PDBTitle: crystal structure of bacillus anthracis transpeptidase enzyme capd,2 crystal form ii Phyre2 PDB 1p4v chain A Region: 66 - 126 Aligned: 52 Modelled: 61 Confidence: 95.0% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:n(4)-(beta-n-acetylglucosaminyl)-l-asparaginase PDBTitle: crystal structure of the glycosylasparaginase precursor2 d151n mutant with glycine Phyre2 PDB 1t3m chain A Region: 89 - 126 Aligned: 38 Modelled: 38 Confidence: 94.7% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:putative l-asparaginase; PDBTitle: structure of the isoaspartyl peptidase with l-asparaginase2 activity from e. coli Phyre2 PDB 1apy chain A Region: 89 - 126 Aligned: 38 Modelled: 38 Confidence: 94.5% Identity: 42% PDB header:hydrolase Chain: A: PDB Molecule:aspartylglucosaminidase; PDBTitle: human aspartylglucosaminidase Phyre2 PDB 2gez chain E Region: 89 - 126 Aligned: 38 Modelled: 38 Confidence: 94.0% Identity: 24% PDB header:hydrolase Chain: E: PDB Molecule:l-asparaginase alpha subunit; PDBTitle: crystal structure of potassium-independent plant asparaginase Phyre2 1 c4y23A_ 2 d2nlza1 3 d2i3oa1 4 c2e0wA_ 5 c2v36A_ 6 c2qm6C_ 7 c2z8jA_ 8 c4gdxA_ 9 c5zjgC_ 10 c3g9kD_ 11 c5zjgD_ 12 c2e0yB_ 13 c4gdxB_ 14 c2v36D_ 15 c2nqoB_ 16 c3ga9S_ 17 c1p4vA_ 18 c1t3mA_ 19 c1apyA_ 20 c2gezE_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99