1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	E	S	L	V	G	E	R	R	A	P	Q	F	R	A	R	L	S	G	P	A	G	P	P	S	V	R	V	G	M	A	V	V	W	L	S	V	I	V	L	L	P	L	A	A	I	V	W	Q	A	A	G	G	G	W	R	A	F	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	A	V	S	S	H	A	A	M	E	S	F	R	V	T	L	T	I	S	T	A	V	T	V	I	N	L	V	F	G	L	L	I	A	W	V	L	V	R	D	D	F	A	G	K	R	I	V	D	A	I	I	D	L	P	F	A	L	P	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	V	A	S	L	V	M	L	A	L	Y	G	N	N	S	P	V	G	L	H	F	Q	H	T	A	T	G	V	G	V	A	L	A	F	V	T	L	P	F	V	V	R	A	V	Q	P	V	L	L	E	I	D	R	E	T	E	E	A	A	A
Secondary structure
SS confidence
Disorder																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	L	G	A	N	G	A	K	I	F	T	S	V	V	L	P	S	L	T	P	A	L	L	S	G	A	G	L	A	F	S	R	A	I	G	E	F	G	S	V	V	L	I	G	G	A	V	P	G	K	T	E	V	S	S	Q	W	I	R	T
Secondary structure
SS confidence
Disorder																																														?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.
Sequence		L	I	E	N	D	D	R	T	G	A	A	A	I	S	V	V	L	L	S	I	S	F	I	V	L	L	I	L	R	V	V	G	A	R	A	A	K	R	E	E	M	A	A
Secondary structure
SS confidence
Disorder					?	?																																			?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 79%) Beta strand ( 0%) TM helix ( 46%) (View membrane topology prediction)

Rank Aligned region

PDB 4tqv chain I Region: 16 - 277 Aligned: 262 Modelled: 262 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: I: PDB Molecule:algm1; PDBTitle: crystal structure of a bacterial abc transporter involved in the2 import of the acidic polysaccharide alginate Phyre2 PDB 3fh6 chain F Region: 21 - 274 Aligned: 254 Modelled: 254 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 3d31 chain D Region: 24 - 269 Aligned: 242 Modelled: 246 Confidence: 100.0% Identity: 28% PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease protein; PDBTitle: modbc from methanosarcina acetivorans Phyre2 PDB 3d31 chain C domain 1 Region: 24 - 269 Aligned: 242 Modelled: 246 Confidence: 100.0% Identity: 28% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2onk chain C Region: 22 - 271 Aligned: 245 Modelled: 250 Confidence: 100.0% Identity: 27% PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda Phyre2 PDB 2onk chain C domain 1 Region: 22 - 271 Aligned: 245 Modelled: 250 Confidence: 100.0% Identity: 27% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain G domain 1 Region: 20 - 270 Aligned: 251 Modelled: 251 Confidence: 100.0% Identity: 19% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain F Region: 53 - 267 Aligned: 215 Modelled: 215 Confidence: 100.0% Identity: 20% PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter Phyre2 PDB 4tqv chain J Region: 16 - 277 Aligned: 253 Modelled: 262 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: J: PDB Molecule:algm2; PDBTitle: crystal structure of a bacterial abc transporter involved in the2 import of the acidic polysaccharide alginate Phyre2 PDB 2r6g chain F domain 2 Region: 56 - 267 Aligned: 212 Modelled: 212 Confidence: 100.0% Identity: 20% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 4ymu chain C Region: 55 - 274 Aligned: 212 Modelled: 220 Confidence: 100.0% Identity: 19% PDB header:protein binding/transport protein Chain: C: PDB Molecule:abc-type amino acid transport system, permease component; PDBTitle: crystal structure of an amino acid abc transporter complex with2 arginines and atps Phyre2 PDB 3dhw chain A domain 1 Region: 68 - 267 Aligned: 195 Modelled: 195 Confidence: 100.0% Identity: 19% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 5kbu chain A Region: 74 - 224 Aligned: 111 Modelled: 111 Confidence: 85.5% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:glutamate receptor 2,voltage-dependent calcium channel PDBTitle: cryo-em structure of glua2-2xstz complex at 7.8 angstrom resolution Phyre2 PDB 2r6g chain F domain 1 Region: 20 - 53 Aligned: 34 Modelled: 34 Confidence: 77.4% Identity: 18% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 2m8g chain X Region: 163 - 193 Aligned: 31 Modelled: 31 Confidence: 39.9% Identity: 16% PDB header:transcription Chain: X: PDB Molecule:transcriptional regulator; PDBTitle: structure, function, and tethering of dna-binding domains in 542 transcriptional activators Phyre2 PDB 4l5e chain A Region: 163 - 193 Aligned: 31 Modelled: 31 Confidence: 35.3% Identity: 19% PDB header:protein binding Chain: A: PDB Molecule:transcriptional regulator (ntrc family); PDBTitle: crystal structure of a. aeolicus ntrc1 dna binding domain Phyre2 PDB 1umq chain A Region: 163 - 193 Aligned: 31 Modelled: 31 Confidence: 29.7% Identity: 19% PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity Phyre2 PDB 1umq chain A Region: 163 - 193 Aligned: 31 Modelled: 31 Confidence: 29.7% Identity: 19% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1ntc chain A Region: 162 - 193 Aligned: 32 Modelled: 32 Confidence: 29.3% Identity: 22% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 2jwa chain A Region: 73 - 106 Aligned: 34 Modelled: 34 Confidence: 22.1% Identity: 9% PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: erbb2 transmembrane segment dimer spatial structure Phyre2 1 c4tqvI_ 2 c3fh6F_ 3 c3d31D_ 4 d3d31c1 5 c2onkC_ 6 d2onkc1 7 d2r6gg1 8 c2r6gF_ 9 c4tqvJ_ 10 d2r6gf2 11 c4ymuC_ 12 d3dhwa1 13 c5kbuA_ 14 d2r6gf1 15 c2m8gX_ 16 c4l5eA_ 17 c1umqA_ 18 d1umqa_ 19 d1ntca_ 20 c2jwaA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38