1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	I	A	D	V	L	R	N	K	G	A	A	V	V	T	I	N	P	D	A	T	V	G	E	L	L	A	G	L	A	E	Q	N	I	G	A	M	V	V	V	G	A	E	G	V	V	G	I	V	S	E	R	D	V	V	R	Q	L	H
Secondary structure
SS confidence
Disorder		?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	Y	G	A	S	V	L	S	R	P	V	A	K	I	M	S	T	T	V	A	T	C	T	K	S	D	T	V	D	K	I	S	V	L	M	T	E	N	R	V	R	H	V	P	V	L	D	G	K	K	L	I	G	I	V	S	I	G	D	V
Secondary structure
SS confidence
Disorder						?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.
Sequence		V	K	S	R	M	G	E	L	E	A	E	Q	Q	Q	L	Q	S	Y	I	T	Q	G
Secondary structure
SS confidence
Disorder											?										?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 46%) Beta strand ( 23%)

Rank Aligned region

PDB 2rc3 chain A domain 1 Region: 1 - 125 Aligned: 125 Modelled: 125 Confidence: 99.9% Identity: 41% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 4fry chain A Region: 1 - 127 Aligned: 124 Modelled: 127 Confidence: 99.9% Identity: 37% PDB header:signaling protein Chain: A: PDB Molecule:putative signal-transduction protein with cbs domains; PDBTitle: the structure of a putative signal-transduction protein with cbs2 domains from burkholderia ambifaria mc40-6 Phyre2 PDB 4o9k chain B Region: 1 - 123 Aligned: 122 Modelled: 123 Confidence: 99.9% Identity: 18% PDB header:isomerase Chain: B: PDB Molecule:arabinose 5-phosphate isomerase; PDBTitle: crystal structure of the cbs pair of a putative d-arabinose 5-2 phosphate isomerase from methylococcus capsulatus in complex with3 cmp-kdo Phyre2 PDB 2qh1 chain B Region: 1 - 137 Aligned: 134 Modelled: 137 Confidence: 99.9% Identity: 19% PDB header:unknown function Chain: B: PDB Molecule:hypothetical protein ta0289; PDBTitle: structure of ta289, a cbs-rubredoxin-like protein, in its fe+2-bound2 state Phyre2 PDB 2d4z chain A domain 3 Region: 1 - 126 Aligned: 123 Modelled: 126 Confidence: 99.9% Identity: 16% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 6h1w chain A Region: 2 - 142 Aligned: 137 Modelled: 141 Confidence: 99.9% Identity: 18% PDB header:unknown function Chain: A: PDB Molecule:mj1004; PDBTitle: crystal structure of protein mj1004 from mathanocaldococcus jannaschii Phyre2 PDB 2o16 chain A domain 3 Region: 1 - 133 Aligned: 129 Modelled: 133 Confidence: 99.9% Identity: 16% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 5awe chain A Region: 3 - 128 Aligned: 123 Modelled: 126 Confidence: 99.9% Identity: 24% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative acetoin utilization protein, acetoin PDBTitle: crystal structure of a hypothetical protein, ttha0829 from thermus2 thermophilus hb8, composed of cystathionine-beta-synthase (cbs) and3 aspartate-kinase chorismate-mutase tyra (act) domains Phyre2 PDB 5nmu chain C Region: 1 - 123 Aligned: 120 Modelled: 123 Confidence: 99.9% Identity: 27% PDB header:photosynthesis Chain: C: PDB Molecule:cbs-cp12; PDBTitle: structure of hexameric cbs-cp12 protein from bloom-forming2 cyanobacteria Phyre2 PDB 3ddj chain A domain 1 Region: 1 - 134 Aligned: 131 Modelled: 134 Confidence: 99.9% Identity: 13% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 1y5h chain A domain 3 Region: 2 - 124 Aligned: 120 Modelled: 123 Confidence: 99.9% Identity: 21% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 3lhh chain A Region: 2 - 128 Aligned: 121 Modelled: 127 Confidence: 99.9% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:cbs domain protein; PDBTitle: the crystal structure of cbs domain protein from shewanella2 oneidensis mr-1. Phyre2 PDB 6coz chain B Region: 1 - 129 Aligned: 126 Modelled: 129 Confidence: 99.9% Identity: 16% PDB header:transport protein Chain: B: PDB Molecule:chloride channel protein 1; PDBTitle: human clc-1 chloride ion channel, c-terminal cytosolic domain Phyre2 PDB 3lfr chain B Region: 1 - 129 Aligned: 123 Modelled: 129 Confidence: 99.9% Identity: 20% PDB header:transport protein Chain: B: PDB Molecule:putative metal ion transporter; PDBTitle: the crystal structure of a cbs domain from a putative metal ion2 transporter bound to amp from pseudomonas syringae to 1.55a Phyre2 PDB 3jtf chain B Region: 2 - 128 Aligned: 120 Modelled: 127 Confidence: 99.9% Identity: 17% PDB header:transport protein Chain: B: PDB Molecule:magnesium and cobalt efflux protein; PDBTitle: the cbs domain pair structure of a magnesium and cobalt efflux protein2 from bordetella parapertussis in complex with amp Phyre2 PDB 1pvm chain A domain 4 Region: 1 - 137 Aligned: 134 Modelled: 137 Confidence: 99.9% Identity: 19% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 4hg0 chain A Region: 1 - 127 Aligned: 122 Modelled: 127 Confidence: 99.9% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:magnesium and cobalt efflux protein corc; PDBTitle: crystal structure of magnesium and cobalt efflux protein corc,2 northeast structural genomics consortium (nesg) target er40 Phyre2 PDB 2ef7 chain A domain 1 Region: 1 - 127 Aligned: 122 Modelled: 126 Confidence: 99.9% Identity: 25% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 2d4z chain B Region: 1 - 126 Aligned: 123 Modelled: 126 Confidence: 99.9% Identity: 20% PDB header:transport protein Chain: B: PDB Molecule:chloride channel protein; PDBTitle: crystal structure of the cytoplasmic domain of the chloride channel2 clc-0 Phyre2 PDB 1pbj chain A domain 3 Region: 2 - 123 Aligned: 118 Modelled: 122 Confidence: 99.9% Identity: 25% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 1 d2rc3a1 2 c4fryA_ 3 c4o9kB_ 4 c2qh1B_ 5 d2d4za3 6 c6h1wA_ 7 d2o16a3 8 c5aweA_ 9 c5nmuC_ 10 d3ddja1 11 d1y5ha3 12 c3lhhA_ 13 c6cozB_ 14 c3lfrB_ 15 c3jtfB_ 16 d1pvma4 17 c4hg0A_ 18 d2ef7a1 19 c2d4zB_ 20 d1pbja3 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99