1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	W	R	T	R	V	V	H	T	T	G	Y	V	Y	Q	S	P	V	T	A	S	Y	N	E	A	R	L	T	P	R	S	S	S	R	Q	N	L	V	L	N	R	V	E	T	I	P	A	T	R	S	Y	R	Y	I	D	Y	W	G	T	A
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	T	A	F	D	L	H	A	P	H	T	E	L	T	V	T	S	S	S	V	V	E	T	E	R	P	E	P	L	A	A	K	A	T	W	A	D	L	Q	S	T	A	V	I	D	R	F	D	E	V	L	R	P	T	P	H	T	P	A	S
Secondary structure
SS confidence
Disorder																														?								?	?	?	?																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	R	V	D	A	V	G	R	R	I	R	K	C	H	E	P	S	E	A	V	V	A	A	A	R	W	A	R	S	E	L	D	Y	I	P	G	T	T	S	V	H	S	S	G	L	D	A	L	E	Q	G	K	G	V	C	Q	D	F	V	H
Secondary structure
SS confidence
Disorder																																							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	S	L	M	V	L	R	S	M	G	I	P	C	R	Y	V	S	G	Y	L	H	P	K	R	D	A	V	V	G	K	T	V	D	G	R	S	H	A	W	V	Q	A	W	T	G	G	W	W	H	Y	D	P	T	N	D	N	E	I	T	E
Secondary structure
SS confidence
Disorder																										?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.
Sequence		Q	Y	I	S	V	G	V	G	R	D	Y	T	D	V	S	P	L	K	G	I	Y	S	G	E	G	V	T	D	L	D	V	V	V	E	I	T	R	L	A
Secondary structure
SS confidence
Disorder																											?		?										?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 19%) Beta strand ( 39%)

Rank Aligned region

PDB 3isr chain B Region: 1 - 278 Aligned: 262 Modelled: 276 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:transglutaminase-like enzymes, putative cysteine protease; PDBTitle: the crystal structure of a putative cysteine protease from cytophaga2 hutchinsonii to 1.9a Phyre2 PDB 6g49 chain A Region: 118 - 233 Aligned: 116 Modelled: 116 Confidence: 99.9% Identity: 28% PDB header:transferase Chain: A: PDB Molecule:protein-glutamine gamma-glutamyltransferase; PDBTitle: crystal structure of the periplasmic domain of tgpa from pseudomonas2 aeruginosa Phyre2 PDB 4xz7 chain A Region: 128 - 235 Aligned: 97 Modelled: 108 Confidence: 99.8% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of a tgase Phyre2 PDB 2q3z chain A domain 4 Region: 171 - 233 Aligned: 63 Modelled: 63 Confidence: 99.6% Identity: 35% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 1g0d chain A domain 4 Region: 171 - 233 Aligned: 63 Modelled: 63 Confidence: 99.6% Identity: 37% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 1vjj chain A domain 4 Region: 171 - 233 Aligned: 63 Modelled: 63 Confidence: 99.5% Identity: 32% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 1ex0 chain A domain 4 Region: 171 - 233 Aligned: 63 Modelled: 63 Confidence: 99.5% Identity: 38% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 2f4m chain A domain 1 Region: 162 - 237 Aligned: 61 Modelled: 61 Confidence: 99.5% Identity: 30% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 3kd4 chain A Region: 37 - 234 Aligned: 196 Modelled: 198 Confidence: 99.4% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:putative protease; PDBTitle: crystal structure of a putative protease (bdi_1141) from2 parabacteroides distasonis atcc 8503 at 2.00 a resolution Phyre2 PDB 1x3z chain A domain 1 Region: 164 - 237 Aligned: 59 Modelled: 59 Confidence: 99.1% Identity: 32% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 1l9m chain B Region: 171 - 233 Aligned: 63 Modelled: 63 Confidence: 99.0% Identity: 33% PDB header:transferase Chain: B: PDB Molecule:protein-glutamine glutamyltransferase e3; PDBTitle: three-dimensional structure of the human transglutaminase 32 enzyme: binding of calcium ions change structure for3 activation Phyre2 PDB 1f13 chain A Region: 171 - 233 Aligned: 63 Modelled: 63 Confidence: 99.0% Identity: 37% PDB header:coagulation factor Chain: A: PDB Molecule:cellular coagulation factor xiii zymogen; PDBTitle: recombinant human cellular coagulation factor xiii Phyre2 PDB 1g0d chain A Region: 171 - 233 Aligned: 63 Modelled: 63 Confidence: 99.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:protein-glutamine gamma-glutamyltransferase; PDBTitle: crystal structure of red sea bream transglutaminase Phyre2 PDB 4u65 chain F Region: 121 - 231 Aligned: 103 Modelled: 111 Confidence: 99.0% Identity: 18% PDB header:transferase/hydrolase Chain: F: PDB Molecule:putative cystine protease; PDBTitle: structure of the periplasmic output domain of the legionella2 pneumophila lapd ortholog cdgs9 in complex with pseudomonas3 fluorescens lapg Phyre2 PDB 1kv3 chain F Region: 171 - 233 Aligned: 63 Modelled: 63 Confidence: 99.0% Identity: 33% PDB header:transferase Chain: F: PDB Molecule:protein-glutamine gamma-glutamyltransferase; PDBTitle: human tissue transglutaminase in gdp bound form Phyre2 PDB 2qsh chain A Region: 137 - 240 Aligned: 104 Modelled: 104 Confidence: 98.7% Identity: 17% PDB header:dna binding protein/dna Chain: A: PDB Molecule:dna repair protein rad4; PDBTitle: crystal structure of rad4-rad23 bound to a mismatch dna Phyre2 PDB 3esw chain A Region: 162 - 237 Aligned: 60 Modelled: 61 Confidence: 98.7% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:peptide-n(4)-(n-acetyl-beta-glucosaminyl)asparagine PDBTitle: complex of yeast pngase with glcnac2-iac. Phyre2 PDB 4fgp chain B Region: 121 - 231 Aligned: 100 Modelled: 111 Confidence: 98.3% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:periplasmic protein; PDBTitle: legionella pneumophila lapg (egta-treated) Phyre2 PDB 2pfr chain B Region: 121 - 235 Aligned: 112 Modelled: 115 Confidence: 97.3% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:arylamine n-acetyltransferase 2; PDBTitle: human n-acetyltransferase 2 Phyre2 PDB 2vfb chain A Region: 123 - 248 Aligned: 123 Modelled: 126 Confidence: 96.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:arylamine n-acetyltransferase; PDBTitle: the structure of mycobacterium marinum arylamine n-2 acetyltransferase Phyre2 1 c3isrB_ 2 c6g49A_ 3 c4xz7A_ 4 d2q3za4 5 d1g0da4 6 d1vjja4 7 d1ex0a4 8 d2f4ma1 9 c3kd4A_ 10 d1x3za1 11 c1l9mB_ 12 c1f13A_ 13 c1g0dA_ 14 c4u65F_ 15 c1kv3F_ 16 c2qshA_ 17 c3eswA_ 18 c4fgpB_ 19 c2pfrB_ 20 c2vfbA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99