1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	A	R	R	I	R	A	A	R	P	L	A	P	H	G	L	P	G	H	L	V	G	F	V	E	A	L	R	G	S	G	I	S	V	G	P	S	E	T	V	D	A	G	R	V	M	A	T	L	G	L	G	D	R	E	V	L	R	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	I	A	C	A	V	L	R	R	P	D	H	R	D	T	Y	D	A	M	F	D	L	W	F	P	A	A	L	G	A	R	A	V	I	T	T	E	D	E	S	A	G	S	G	G	L	P	P	D	D	V	E	A	M	R	Q	L	L	L	D
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	L	A	N	N	Q	D	L	A	G	K	D	E	R	L	V	E	M	I	A	R	I	V	E	A	Y	G	K	Y	S	S	S	R	G	P	S	F	S	S	Y	Q	A	L	K	A	M	A	L	D	E	L	E	G	K	L	L	A	G	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?										?	?	?	?	?	?	?	?	?	?	?	?	?								?	?	?	?	?	?	?							?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	P	Y	G	D	E	P	T	A	T	Q	E	Q	I	A	K	A	L	A	A	Q	K	I	A	Q	L	R	R	M	V	D	A	E	T	K	R	R	T	A	E	Q	L	G	R	E	H	V	Q	M	Y	G	I	P	Q	L	S	E	N	V	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	L	R	A	S	G	E	Q	L	R	Q	M	R	R	V	V	A	P	L	A	R	T	L	A	T	R	L	A	A	R	R	R	R	A	R	A	G	S	I	D	L	R	K	T	L	R	K	S	M	S	T	G	G	V	P	I	D	L	V	L
Secondary structure
SS confidence
Disorder		?		?																											?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		H	K	P	R	P	A	R	P	E	L	V	V	L	C	D	V	S	G	S	V	A	G	F	S	H	F	T	L	L	L	V	H	A	L	R	Q	Q	F	S	R	V	R	V	F	A	F	I	D	S	T	D	E	V	T	H	M	F	G	P	E
Secondary structure
SS confidence
Disorder		?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	D	L	A	I	A	I	Q	R	I	T	R	E	A	G	V	Y	A	R	D	G	H	S	D	Y	G	N	A	F	V	S	F	M	Q	G	F	P	N	V	L	S	P	R	S	S	L	L	V	L	G	D	G	R	T	N	Y	R	N	P	A
Secondary structure
SS confidence
Disorder			?											?	?	?	?	?	?	?	?																			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		T	D	V	L	A	D	M	V	T	A	S	R	H	A	H	W	L	N	P	E	P	K	H	L	W	G	S	G	D	S	A	V	P	R	Y	Q	E	V	I	T	M	H	E	C	R	S	A	K	Q	L	A	T	V	I	D	Q	L	L	P	V
Secondary structure
SS confidence
Disorder																										?	?																																	?	?
Disorder confidence
Sequence
Secondary structure
SS confidence
Disorder
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 34%) Alpha helix ( 59%) Beta strand ( 7%)

Rank Aligned region

PDB 2i6s chain A Region: 299 - 480 Aligned: 172 Modelled: 182 Confidence: 99.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:complement c2a fragment; PDBTitle: complement component c2a Phyre2 PDB 2ok5 chain A domain 1 Region: 294 - 478 Aligned: 181 Modelled: 185 Confidence: 98.9% Identity: 10% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 4hqn chain B Region: 305 - 478 Aligned: 173 Modelled: 174 Confidence: 98.9% Identity: 14% PDB header:cell adhesion Chain: B: PDB Molecule:sporozoite surface protein 2; PDBTitle: crystal structure of manganese-loaded plasmodium vivax trap protein Phyre2 PDB 4fx5 chain A Region: 292 - 478 Aligned: 184 Modelled: 185 Confidence: 98.8% Identity: 14% PDB header:blood clotting Chain: A: PDB Molecule:von willebrand factor type a; PDBTitle: von willebrand factor type a from catenulispora acidiphila Phyre2 PDB 1yvr chain A domain 2 Region: 304 - 436 Aligned: 122 Modelled: 133 Confidence: 98.8% Identity: 15% Fold: vWA-like Superfamily: vWA-like Family: RoRNP C-terminal domain-like Phyre2 PDB 1rs0 chain A Region: 309 - 478 Aligned: 164 Modelled: 170 Confidence: 98.8% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: crystal structure analysis of the bb segment of factor b2 complexed with di-isopropyl-phosphate (dip) Phyre2 PDB 4wfq chain A Region: 303 - 479 Aligned: 168 Modelled: 177 Confidence: 98.7% Identity: 13% PDB header:transcription Chain: A: PDB Molecule:suppressor of stem-loop protein 1; PDBTitle: crystal structure of tfiih subunit Phyre2 PDB 5iy7 chain 0 Region: 303 - 479 Aligned: 171 Modelled: 177 Confidence: 98.7% Identity: 13% PDB header:transcription, transferase/dna Chain: 0: PDB Molecule:general transcription factor iih subunit 2; PDBTitle: human holo-pic in the open state Phyre2 PDB 2nvo chain A Region: 304 - 437 Aligned: 123 Modelled: 134 Confidence: 98.7% Identity: 17% PDB header:rna binding protein Chain: A: PDB Molecule:ro sixty-related protein, rsr; PDBTitle: crystal structure of deinococcus radiodurans ro (rsr) protein Phyre2 PDB 3ibs chain A Region: 306 - 478 Aligned: 167 Modelled: 173 Confidence: 98.7% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein batb; PDBTitle: crystal structure of conserved hypothetical protein batb from2 bacteroides thetaiotaomicron Phyre2 PDB 2ok5 chain A Region: 309 - 478 Aligned: 166 Modelled: 170 Confidence: 98.6% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: human complement factor b Phyre2 PDB 6fpz chain A Region: 304 - 433 Aligned: 128 Modelled: 130 Confidence: 98.6% Identity: 13% PDB header:structural protein Chain: A: PDB Molecule:inter-alpha-trypsin inhibitor heavy chain h1; PDBTitle: inter-alpha-inhibitor heavy chain 1, d298a Phyre2 PDB 4rck chain B Region: 308 - 477 Aligned: 164 Modelled: 166 Confidence: 98.6% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:hypothetical membrane spanning protein; PDBTitle: crystal structure of uncharacterized membrane spanning protein from2 vibrio fischeri Phyre2 PDB 2x31 chain F Region: 303 - 435 Aligned: 127 Modelled: 133 Confidence: 98.5% Identity: 17% PDB header:ligase Chain: F: PDB Molecule:magnesium-chelatase 60 kda subunit; PDBTitle: modelling of the complex between subunits bchi and bchd of magnesium2 chelatase based on single-particle cryo-em reconstruction at 7.5 ang Phyre2 PDB 5a8j chain A Region: 305 - 478 Aligned: 159 Modelled: 174 Confidence: 98.4% Identity: 13% PDB header:transcription Chain: A: PDB Molecule:vwa2; PDBTitle: crystal structure of the arnb paralog vwa2 from2 sulfolobus acidocaldarius Phyre2 PDB 4hqf chain A Region: 305 - 478 Aligned: 170 Modelled: 174 Confidence: 98.4% Identity: 14% PDB header:cell adhesion Chain: A: PDB Molecule:thrombospondin-related anonymous protein, trap; PDBTitle: crystal structure of plasmodium falciparum trap, i4 form Phyre2 PDB 4oku chain A Region: 305 - 435 Aligned: 129 Modelled: 131 Confidence: 98.3% Identity: 10% PDB header:cell adhesion Chain: A: PDB Molecule:micronemal protein mic2; PDBTitle: structure of toxoplasma gondii promic2 Phyre2 PDB 1yvr chain A Region: 304 - 432 Aligned: 118 Modelled: 129 Confidence: 98.3% Identity: 16% PDB header:rna binding protein Chain: A: PDB Molecule:60-kda ss-a/ro ribonucleoprotein; PDBTitle: ro autoantigen Phyre2 PDB 1shu chain X Region: 305 - 478 Aligned: 162 Modelled: 174 Confidence: 98.2% Identity: 17% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 6o9l chain 6 Region: 308 - 434 Aligned: 124 Modelled: 127 Confidence: 98.1% Identity: 15% PDB header:transcription/dna Chain: 6: PDB Molecule:general transcription factor iih subunit 2; PDBTitle: human holo-pic in the closed state Phyre2 1 c2i6sA_ 2 d2ok5a1 3 c4hqnB_ 4 c4fx5A_ 5 d1yvra2 6 c1rs0A_ 7 c4wfqA_ 8 c5iy70_ 9 c2nvoA_ 10 c3ibsA_ 11 c2ok5A_ 12 c6fpzA_ 13 c4rckB_ 14 c2x31F_ 15 c5a8jA_ 16 c4hqfA_ 17 c4okuA_ 18 c1yvrA_ 19 d1shux_ 20 c6o9l6_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108