1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	Q	R	T	N	V	V	Q	P	L	N	T	L	R	M	V	W	I	Q	V	A	G	I	I	P	A	T	A	G	I	A	A	T	V	Y	A	Q	L	A	M	G	D	S	W	R	I	G	V	D	E	Q	E	N	T	T	L	V	R	T
Secondary structure
SS confidence
Disorder		?	?																																												?	?				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	P	F	K	W	V	R	H	P	I	Y	T	A	M	M	A	F	G	L	G	L	L	L	V	T	P	N	L	V	A	L	A	G	F	I	L	L	V	A	T	L	E	V	H	V	R	R	V	E	E	P	Y	L	L	R	T	H	S	A	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.
Sequence		Y	R	G	Y	T	A	S	V	G	R	F	V	P	G	V	G	L	I	R
Secondary structure
SS confidence
Disorder																?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 78%) Beta strand ( 0%) TM helix ( 42%) (View membrane topology prediction)

Rank Aligned region

PDB 5v7p chain A Region: 15 - 139 Aligned: 125 Modelled: 125 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:protein-s-isoprenylcysteine o-methyltransferase; PDBTitle: atomic structure of the eukaryotic intramembrane ras methyltransferase2 icmt (isoprenylcysteine carboxyl methyltransferase), in complex with3 a monobody Phyre2 PDB 4a2n chain B Region: 8 - 134 Aligned: 127 Modelled: 127 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:isoprenylcysteine carboxyl methyltransferase; PDBTitle: crystal structure of ma-icmt Phyre2 PDB 4quv chain B Region: 17 - 135 Aligned: 119 Modelled: 119 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase, membrane protein Chain: B: PDB Molecule:delta(14)-sterol reductase; PDBTitle: structure of an integral membrane delta(14)-sterol reductase Phyre2 PDB 1nu9 chain C domain 1 Region: 102 - 126 Aligned: 25 Modelled: 25 Confidence: 41.6% Identity: 24% Fold: immunoglobulin/albumin-binding domain-like Superfamily: Staphylocoagulase Family: Staphylocoagulase Phyre2 PDB 2jp3 chain A Region: 21 - 61 Aligned: 41 Modelled: 41 Confidence: 37.1% Identity: 20% PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Phyre2 PDB 4y9i chain A Region: 111 - 133 Aligned: 22 Modelled: 23 Confidence: 35.4% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:mycobacterium tuberculosis paralogous family 11; PDBTitle: structure of f420-h2 dependent reductase (fdr-a) msmeg_2027 Phyre2 PDB 3r5y chain C Region: 111 - 133 Aligned: 22 Modelled: 23 Confidence: 24.1% Identity: 23% PDB header:unknown function Chain: C: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of a deazaflavin-dependent nitroreductase from nocardia2 farcinica, with co-factor f420 Phyre2 PDB 5e8j chain C Region: 105 - 127 Aligned: 23 Modelled: 23 Confidence: 19.1% Identity: 13% PDB header:translation Chain: C: PDB Molecule:rnmt-activating mini protein; PDBTitle: crystal structure of mrna cap guanine-n7 methyltransferase in complex2 with ram Phyre2 PDB 2fug chain 1 domain 1 Region: 113 - 137 Aligned: 25 Modelled: 25 Confidence: 17.3% Identity: 16% Fold: Bromodomain-like Superfamily: Nqo1C-terminal domain-like Family: Nqo1C-terminal domain-like Phyre2 PDB 3r5w chain O Region: 111 - 133 Aligned: 22 Modelled: 23 Confidence: 16.0% Identity: 27% PDB header:oxidoreductase Chain: O: PDB Molecule:deazaflavin-dependent nitroreductase; PDBTitle: structure of ddn, the deazaflavin-dependent nitroreductase from2 mycobacterium tuberculosis involved in bioreductive activation of pa-3 824, with co-factor f420 Phyre2 PDB 1e7l chain A domain 1 Region: 68 - 75 Aligned: 8 Modelled: 8 Confidence: 14.3% Identity: 25% Fold: LEM/SAP HeH motif Superfamily: Recombination endonuclease VII, C-terminal and dimerization domains Family: Recombination endonuclease VII, C-terminal and dimerization domains Phyre2 PDB 1p58 chain E Region: 65 - 100 Aligned: 35 Modelled: 36 Confidence: 13.9% Identity: 37% PDB header:virus Chain: E: PDB Molecule:envelope protein m; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 1p58 chain F Region: 65 - 77 Aligned: 13 Modelled: 13 Confidence: 13.1% Identity: 46% PDB header:virus Chain: F: PDB Molecule:envelope protein m; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 5ht7 chain A Region: 57 - 71 Aligned: 15 Modelled: 15 Confidence: 11.2% Identity: 27% PDB header:metal binding protein Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a transition-metal-ion-binding betagamma-2 crystallin from methanosaeta thermophila Phyre2 PDB 3h96 chain B Region: 111 - 133 Aligned: 22 Modelled: 23 Confidence: 10.6% Identity: 23% PDB header:flavoprotein Chain: B: PDB Molecule:f420-h2 dependent reductase a; PDBTitle: msmeg_3358 f420 reductase Phyre2 PDB 3r5z chain B Region: 111 - 133 Aligned: 22 Modelled: 23 Confidence: 10.3% Identity: 18% PDB header:unknown function Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of a deazaflavin-dependent reductase from nocardia2 farcinica, with co-factor f420 Phyre2 PDB 1xyq chain A Region: 106 - 127 Aligned: 22 Modelled: 22 Confidence: 8.9% Identity: 23% Fold: Prion-like Superfamily: Prion-like Family: Prion-like Phyre2 PDB 4b03 chain D Region: 65 - 100 Aligned: 35 Modelled: 36 Confidence: 8.2% Identity: 29% PDB header:virus Chain: D: PDB Molecule:dengue virus 1 prm protein; PDBTitle: 6a electron cryomicroscopy structure of immature dengue virus serotype2 1 Phyre2 PDB 4ct7 chain A Region: 121 - 133 Aligned: 13 Modelled: 13 Confidence: 7.0% Identity: 31% PDB header:transcription Chain: A: PDB Molecule:ccr4-not transcription complex subunit 1; PDBTitle: cnot9-cnot1 complex with bound tryptophan Phyre2 PDB 6em5 chain V Region: 111 - 123 Aligned: 13 Modelled: 13 Confidence: 6.7% Identity: 23% PDB header:ribosome Chain: V: PDB Molecule:60s ribosomal protein l23-a; PDBTitle: state d architectural model (nsa1-tap flag-ytm1) - visualizing the2 assembly pathway of nucleolar pre-60s ribosomes Phyre2 1 c5v7pA_ 2 c4a2nB_ 3 c4quvB_ 4 d1nu9c1 5 c2jp3A_ 6 c4y9iA_ 7 c3r5yC_ 8 c5e8jC_ 9 d2fug11 10 c3r5wO_ 11 d1e7la1 12 c1p58E_ 13 c1p58F_ 14 c5ht7A_ 15 c3h96B_ 16 c3r5zB_ 17 d1xyqa_ 18 c4b03D_ 19 c4ct7A_ 20 c6em5v_ 21 22 23 24 25 26