1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	A	P	L	D	R	A	P	V	T	D	L	P	A	N	N	K	G	R	D	R	T	H	W	L	Y	L	A	V	I	F	A	V	I	A	G	V	I	V	G	L	T	A	P	S	T	G	K	S	L	T	V	L	G	T	V	F	V	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	I	K	M	M	I	A	P	V	I	F	C	T	I	V	L	G	I	G	S	V	R	K	A	A	A	V	G	K	V	G	G	L	A	L	A	Y	F	L	T	M	S	S	V	A	L	G	I	G	L	I	V	G	N	L	L	S	P	G	R
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?	?																																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	L	H	L	R	P	G	A	V	G	S	G	A	A	L	A	G	Q	A	A	E	S	H	G	I	A	G	F	I	Q	Q	I	I	P	R	S	L	P	S	A	L	T	E	G	N	V	L	Q	V	L	L	V	A	L	L	V	G	F	A	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	G	L	G	P	A	G	E	S	I	L	R	A	V	E	N	L	Q	K	L	V	F	K	V	L	V	M	V	L	W	L	A	P	I	G	A	F	G	A	I	A	N	I	V	A	T	T	G	F	N	A	V	T	N	L	L	L	L	M	A
Secondary structure
SS confidence
Disorder		?	?	?		?	?																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	F	Y	L	T	C	V	V	F	V	F	G	V	L	G	V	L	L	R	I	V	S	G	L	S	I	F	R	L	L	R	Y	L	A	R	E	Y	L	L	I	F	A	T	S	S	S	E	V	V	L	P	R	L	I	T	K	M	K	H	L
Secondary structure
SS confidence
Disorder																																												?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	V	Q	S	S	T	V	G	V	V	V	P	T	G	Y	S	F	N	L	D	G	T	A	I	Y	L	T	M	A	S	L	F	I	A	D	A	M	G	H	R	L	T	W	G	E	Q	I	A	L	L	A	F	M	I	I	A	S	K	G	A
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	G	V	S	G	A	G	L	A	T	L	A	G	G	L	Q	A	H	R	P	E	L	L	D	G	V	G	L	I	V	G	I	D	R	F	M	S	E	A	R	S	L	T	N	F	S	G	N	A	V	A	T	I	L	V	A	S	W	T	K
Secondary structure
SS confidence
Disorder		?	?	?														?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		T	I	D	L	S	K	A	D	E	V	L	R	G	R	D	P	F	D	E	S	T	M	V	D	P	H	D	E	E	P	P	A	A	T	P	H	G	G	G	V	P	T	N	P	A	L	C	D	F	E	Q	V	S	L	G	G	L	V	G	R
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.
Sequence		P	A	G	P	Q	R	A	D	V	D	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 29%) Alpha helix ( 72%) Beta strand ( 0%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 6gct chain A Region: 18 - 421 Aligned: 402 Modelled: 404 Confidence: 100.0% Identity: 25% PDB header:membrane protein Chain: A: PDB Molecule:neutral amino acid transporter b(0); PDBTitle: cryo-em structure of the human neutral amino acid transporter asct2 Phyre2 PDB 4ky0 chain B Region: 22 - 427 Aligned: 390 Modelled: 393 Confidence: 100.0% Identity: 30% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:proton/glutamate symporter, sdf family; PDBTitle: crystal structure of a substrate-free glutamate transporter homologue2 from thermococcus kodakarensis Phyre2 PDB 2nww chain A domain 1 Region: 26 - 419 Aligned: 385 Modelled: 394 Confidence: 100.0% Identity: 31% Fold: Proton glutamate symport protein Superfamily: Proton glutamate symport protein Family: Proton glutamate symport protein Phyre2 PDB 5lm4 chain A Region: 18 - 428 Aligned: 380 Modelled: 395 Confidence: 100.0% Identity: 26% PDB header:transport protein Chain: A: PDB Molecule:excitatory amino acid transporter 1,neutral amino acid PDBTitle: structure of the thermostalilized eaat1 cryst-ii mutant in complex2 with l-asp and the allosteric inhibitor ucph101 Phyre2 PDB 4k0e chain A Region: 165 - 264 Aligned: 93 Modelled: 100 Confidence: 83.6% Identity: 20% PDB header:transport protein Chain: A: PDB Molecule:heavy metal cation tricomponent efflux pump znea(czca- PDBTitle: x-ray crystal structure of a heavy metal efflux pump, crystal form ii Phyre2 PDB 6ows chain B Region: 165 - 264 Aligned: 100 Modelled: 100 Confidence: 63.2% Identity: 14% PDB header:membrane protein Chain: B: PDB Molecule:efflux pump membrane transporter; PDBTitle: cryo-em structure of an acinetobacter baumannii multidrug efflux pump Phyre2 PDB 4mt1 chain A Region: 165 - 264 Aligned: 100 Modelled: 100 Confidence: 63.2% Identity: 8% PDB header:membrane protein, tranport protein Chain: A: PDB Molecule:drug efflux protein; PDBTitle: crystal structure of the neisseria gonorrhoeae mtrd inner membrane2 multidrug efflux pump Phyre2 PDB 5lq3 chain F Region: 165 - 272 Aligned: 108 Modelled: 108 Confidence: 59.1% Identity: 11% PDB header:transport protein Chain: F: PDB Molecule:cmeb; PDBTitle: structures and transport dynamics of the campylobacter jejuni2 multidrug efflux pump cmeb Phyre2 PDB 4czb chain B Region: 167 - 359 Aligned: 172 Modelled: 193 Confidence: 57.8% Identity: 13% PDB header:membrane protein Chain: B: PDB Molecule:na(+)/h(+) antiporter 1; PDBTitle: structure of the sodium proton antiporter mjnhap1 from2 methanocaldococcus jannaschii at ph 8. Phyre2 PDB 4r0c chain B Region: 98 - 351 Aligned: 225 Modelled: 225 Confidence: 53.9% Identity: 18% PDB header:membrane protein Chain: B: PDB Molecule:abgt putative transporter family; PDBTitle: crystal structure of the alcanivorax borkumensis ydah transporter2 reveals an unusual topology Phyre2 PDB 5a1s chain B Region: 164 - 312 Aligned: 144 Modelled: 149 Confidence: 53.4% Identity: 10% PDB header:transport protein Chain: B: PDB Molecule:citrate-sodium symporter; PDBTitle: crystal structure of the sodium-dependent citrate symporter secits2 form salmonella enterica. Phyre2 PDB 4n7w chain A Region: 20 - 295 Aligned: 219 Modelled: 255 Confidence: 50.8% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:transporter, sodium/bile acid symporter family; PDBTitle: crystal structure of the sodium bile acid symporter from yersinia2 frederiksenii Phyre2 PDB 1iwg chain A domain 8 Region: 165 - 268 Aligned: 104 Modelled: 104 Confidence: 48.5% Identity: 15% Fold: Multidrug efflux transporter AcrB transmembrane domain Superfamily: Multidrug efflux transporter AcrB transmembrane domain Family: Multidrug efflux transporter AcrB transmembrane domain Phyre2 PDB 1oy8 chain A Region: 165 - 268 Aligned: 104 Modelled: 104 Confidence: 47.4% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:acriflavine resistance protein b; PDBTitle: structural basis of multiple drug binding capacity of the acrb2 multidrug efflux pump Phyre2 PDB 2yvx chain D Region: 6 - 117 Aligned: 103 Modelled: 112 Confidence: 47.3% Identity: 11% PDB header:transport protein Chain: D: PDB Molecule:mg2+ transporter mgte; PDBTitle: crystal structure of magnesium transporter mgte Phyre2 PDB 2v50 chain A Region: 165 - 258 Aligned: 94 Modelled: 94 Confidence: 43.9% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein mexb; PDBTitle: the missing part of the bacterial mexab-oprm system: structural2 determination of the multidrug exporter mexb Phyre2 PDB 4k0e chain C Region: 165 - 261 Aligned: 93 Modelled: 97 Confidence: 30.2% Identity: 23% PDB header:transport protein Chain: C: PDB Molecule:heavy metal cation tricomponent efflux pump znea(czca- PDBTitle: x-ray crystal structure of a heavy metal efflux pump, crystal form ii Phyre2 PDB 6dmo chain A Region: 165 - 265 Aligned: 92 Modelled: 101 Confidence: 29.2% Identity: 17% PDB header:protein binding Chain: A: PDB Molecule:protein patched homolog 1; PDBTitle: cryo-em structure of human ptch1 with three mutations2 l282q/t500f/p504l Phyre2 PDB 5mg3 chain D Region: 165 - 264 Aligned: 90 Modelled: 100 Confidence: 24.5% Identity: 11% PDB header:chaperone Chain: D: PDB Molecule:protein translocase subunit secd; PDBTitle: em fitted model of bacterial holo-translocon Phyre2 PDB 5i6x chain A Region: 84 - 273 Aligned: 178 Modelled: 190 Confidence: 17.6% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:sodium-dependent serotonin transporter; PDBTitle: x-ray structure of the ts3 human serotonin transporter complexed with2 paroxetine at the central site Phyre2 1 c6gctA_ 2 c4ky0B_ 3 d2nwwa1 4 c5lm4A_ 5 c4k0eA_ 6 c6owsB_ 7 c4mt1A_ 8 c5lq3F_ 9 c4czbB_ 10 c4r0cB_ 11 c5a1sB_ 12 c4n7wA_ 13 d1iwga8 14 c1oy8A_ 15 c2yvxD_ 16 c2v50A_ 17 c4k0eC_ 18 c6dmoA_ 19 c5mg3D_ 20 c5i6xA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63