1

.

.

.

.

.

.

.

.

10

.

.

.

.

.

.

.

.

.

20

.

.

.

.

.

.

.

.

.

30

.

.

.

.

.

.

.

.

.

40

.

.

.

.

.

.

.

.

.

50

.

.

.

.

.

.

.

.

.

60

Sequence

V

G

R

A

V

S

V

R

H

G

S

G

A

L

D

L

P

G

A

A

A

S

R

R

L

R

V

G

Q

P

I

Q

P

S

P

A

P

L

A

R

G

S

V

D

S

I

V

E

I

S

C

C

P

S

A

G

P

R

G

P

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

.

.

.

.

.

.

.

.

.

80

.

.

.

.

.

.

.

.

.

90

.

.

.

.

.

.

.

.

.

100

.

.

.

.

.

.

.

.

.

110

.

.

.

.

.

.

.

.

.

120

Sequence

Y

D

N

D

L

D

S

S

S

P

A

N

R

D

I

S

S

I

T

S

R

S

R

R

G

G

T

I

V

V

A

G

Q

K

C

G

F

G

S

A

V

S

L

R

P

R

R

Y

R

E

P

N

H

A

N

I

V

T

P

D

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

130

.

.

Sequence

T

D

L

S

P

S

W

P

W

S

G

I

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 44%) Alpha helix ( 6%) Beta strand ( 20%)

Rank Aligned region

PDB 5muu chain C Region: 34 - 45 Aligned: 12 Modelled: 12 Confidence: 35.2% Identity: 75% PDB header:virus Chain: C: PDB Molecule:packaging enzyme p4; PDBTitle: dsrna bacteriophage phi6 nucleocapsid Phyre2 PDB 6esc chain A Region: 84 - 129 Aligned: 46 Modelled: 46 Confidence: 25.6% Identity: 24% PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein b; PDBTitle: crystal structure of pseudorabies virus glycoprotein b Phyre2 PDB 3vba chain E Region: 84 - 99 Aligned: 16 Modelled: 16 Confidence: 17.7% Identity: 44% PDB header:lyase Chain: E: PDB Molecule:isopropylmalate/citramalate isomerase small subunit; PDBTitle: crystal structure of methanogen 3-isopropylmalate isomerase small2 subunit Phyre2 PDB 3h5j chain A Region: 84 - 99 Aligned: 16 Modelled: 16 Confidence: 15.7% Identity: 44% PDB header:lyase Chain: A: PDB Molecule:3-isopropylmalate dehydratase small subunit; PDBTitle: leud_1-168 small subunit of isopropylmalate isomerase (rv2987c) from2 mycobacterium tuberculosis Phyre2 PDB 3q3w chain B Region: 84 - 99 Aligned: 16 Modelled: 16 Confidence: 15.5% Identity: 31% PDB header:transferase Chain: B: PDB Molecule:3-isopropylmalate dehydratase small subunit; PDBTitle: isopropylmalate isomerase small subunit from campylobacter jejuni. Phyre2 PDB 2pkp chain A Region: 84 - 99 Aligned: 16 Modelled: 16 Confidence: 15.0% Identity: 44% PDB header:lyase Chain: A: PDB Molecule:homoaconitase small subunit; PDBTitle: crystal structure of 3-isopropylmalate dehydratase (leud)2 from methhanocaldococcus jannaschii dsm2661 (mj1271) Phyre2 PDB 2gia chain B Region: 33 - 76 Aligned: 44 Modelled: 44 Confidence: 14.7% Identity: 39% PDB header:translation Chain: B: PDB Molecule:mitochondrial rna-binding protein 1; PDBTitle: crystal structures of trypanosoma bruciei mrp1/mrp2 Phyre2 PDB 2gia chain B domain 1 Region: 33 - 76 Aligned: 44 Modelled: 44 Confidence: 14.7% Identity: 39% Fold: ssDNA-binding transcriptional regulator domain Superfamily: ssDNA-binding transcriptional regulator domain Family: Guide RNA binding protein gBP Phyre2 PDB 2hcu chain A Region: 78 - 99 Aligned: 22 Modelled: 22 Confidence: 14.3% Identity: 27% PDB header:lyase Chain: A: PDB Molecule:3-isopropylmalate dehydratase small subunit; PDBTitle: crystal structure of smu.1381 (or leud) from streptococcus mutans Phyre2 PDB 2gum chain A domain 1 Region: 84 - 129 Aligned: 46 Modelled: 46 Confidence: 14.0% Identity: 17% Fold: Viral glycoprotein ectodomain-like Superfamily: Viral glycoprotein ectodomain-like Family: Glycoprotein B-like Phyre2 PDB 1v7l chain A Region: 84 - 99 Aligned: 16 Modelled: 16 Confidence: 13.7% Identity: 56% Fold: The "swivelling" beta/beta/alpha domain Superfamily: LeuD/IlvD-like Family: LeuD-like Phyre2 PDB 5v2s chain A Region: 83 - 129 Aligned: 47 Modelled: 47 Confidence: 12.7% Identity: 17% PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein b; PDBTitle: crystal structure of glycoprotein b from herpes simplex virus type i Phyre2 PDB 6adq chain P Region: 110 - 132 Aligned: 23 Modelled: 23 Confidence: 10.9% Identity: 26% PDB header:electron transport Chain: P: PDB Molecule:prokaryotic respiratory supercomplex associate factor 1 PDBTitle: respiratory complex ciii2civ2sod2 from mycobacterium smegmatis Phyre2 PDB 1ppy chain A Region: 10 - 31 Aligned: 20 Modelled: 22 Confidence: 10.4% Identity: 40% Fold: Double psi beta-barrel Superfamily: ADC-like Family: Pyruvoyl dependent aspartate decarboxylase, ADC Phyre2 PDB 2akj chain A domain 4 Region: 43 - 62 Aligned: 20 Modelled: 20 Confidence: 9.6% Identity: 30% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 3hfk chain B Region: 9 - 49 Aligned: 41 Modelled: 41 Confidence: 9.2% Identity: 27% PDB header:isomerase Chain: B: PDB Molecule:4-methylmuconolactone methylisomerase; PDBTitle: crystal structure of 4-methylmuconolactone methylisomerase (h52a) in2 complex with 4-methylmuconolactone Phyre2 PDB 3fvc chain A Region: 84 - 129 Aligned: 46 Modelled: 46 Confidence: 8.7% Identity: 15% PDB header:viral protein Chain: A: PDB Molecule:glycoprotein gp110; PDBTitle: crystal structure of a trimeric variant of the epstein-barr virus2 glycoprotein b Phyre2 PDB 3nw8 chain B Region: 84 - 129 Aligned: 46 Modelled: 46 Confidence: 7.7% Identity: 17% PDB header:viral protein Chain: B: PDB Molecule:envelope glycoprotein b; PDBTitle: glycoprotein b from herpes simplex virus type 1, y179s mutant, high-ph Phyre2 PDB 5t7e chain D Region: 93 - 130 Aligned: 38 Modelled: 38 Confidence: 7.2% Identity: 16% PDB header:transferase Chain: D: PDB Molecule:phosphinothricin n-acetyltransferase; PDBTitle: crystal structure of streptomyces hygroscopicus bialaphos resistance2 (bar) protein in complex with coenzyme a and l-phosphinothricin Phyre2 PDB 2m05 chain A Region: 47 - 54 Aligned: 8 Modelled: 8 Confidence: 7.2% Identity: 63% PDB header:unknown function Chain: A: PDB Molecule:beta-amyloid-like protein; PDBTitle: structure of module 2 from the e1 domain of c. elegans apl-1 Phyre2 1 c5muuC_ 2 c6escA_ 3 c3vbaE_ 4 c3h5jA_ 5 c3q3wB_ 6 c2pkpA_ 7 c2giaB_ 8 d2giab1 9 c2hcuA_ 10 d2guma1 11 d1v7la_ 12 c5v2sA_ 13 c6adqP_ 14 d1ppya_ 15 d2akja4 16 c3hfkB_ 17 c3fvcA_ 18 c3nw8B_ 19 c5t7eD_ 20 c2m05A_ 21 22 23 24 25 26 27 28