1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	P	R	Q	R	L	T	V	L	A	T	G	L	G	I	F	M	V	F	V	D	V	N	I	V	N	V	A	L	P	S	I	Q	K	V	F	H	T	G	E	Q	G	L	Q	W	A	V	A	G	Y	S	L	G	M	A	A	V	L	M
Secondary structure
SS confidence
Disorder		?	?	?	?																																	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	C	A	L	L	G	D	R	Y	G	R	R	R	S	F	V	F	G	V	T	L	F	V	V	S	S	I	V	C	V	L	P	V	S	L	A	V	F	T	V	A	R	V	I	Q	G	L	G	A	A	F	I	S	V	L	S	L	A	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	H	S	F	P	N	P	R	M	K	A	R	A	I	S	N	W	M	A	I	G	M	V	G	A	A	S	A	P	A	L	G	G	L	M	V	D	G	L	G	W	R	S	V	F	L	V	N	V	P	L	G	A	I	V	W	L	L	T	L
Secondary structure
SS confidence
Disorder				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	G	V	D	E	S	Q	D	P	E	P	T	Q	L	D	W	V	G	Q	L	T	L	I	P	A	V	A	L	I	A	Y	T	I	I	E	A	P	R	F	D	R	Q	S	A	G	F	V	A	A	L	L	L	A	A	G	V	L	L	W	L
Secondary structure
SS confidence
Disorder									?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	V	R	H	E	H	R	A	A	F	P	L	V	D	L	K	L	F	A	E	P	L	Y	R	S	V	L	I	V	Y	F	V	V	M	S	C	F	F	G	T	L	M	V	I	T	Q	H	F	Q	N	V	R	D	L	S	P	L	H	A	G
Secondary structure
SS confidence
Disorder													?							?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	M	M	L	P	V	P	A	G	F	G	V	A	S	L	L	A	G	R	A	V	N	K	W	G	P	Q	L	P	V	L	T	C	L	A	A	M	F	I	G	L	A	I	F	A	I	S	M	D	H	A	H	P	V	A	L	V	G	L	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		I	F	G	A	G	A	G	G	C	A	T	P	L	L	H	L	G	M	T	K	V	D	D	G	R	A	G	M	A	A	G	M	L	N	L	Q	R	S	L	G	G	I	F	G	V	A	F	L	G	T	I	V	A	A	W	L	G	A	A	L
Secondary structure
SS confidence
Disorder																				?							?	?	?																												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	N	T	M	A	D	E	I	P	D	P	I	A	R	A	I	V	V	D	V	I	V	D	S	A	N	P	H	A	H	A	A	F	I	G	P	G	H	R	I	T	A	A	Q	E	D	E	I	V	L	A	A	D	A	V	F	V	S	G	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.
Sequence		K	L	A	L	G	G	A	A	V	L	L	T	G	A	F	V	L	G	W	T	R	F	P	R	T	P	A	S
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 80%) Beta strand ( 0%) TM helix ( 57%) (View membrane topology prediction)

Rank Aligned region

PDB 1pw4 chain A Region: 3 - 505 Aligned: 398 Modelled: 399 Confidence: 100.0% Identity: 14% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 4zp0 chain A Region: 1 - 418 Aligned: 365 Modelled: 366 Confidence: 100.0% Identity: 18% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 6e9o chain A Region: 2 - 503 Aligned: 391 Modelled: 391 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 3wdo chain A Region: 1 - 508 Aligned: 389 Modelled: 392 Confidence: 100.0% Identity: 20% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 4cl5 chain B Region: 2 - 506 Aligned: 434 Modelled: 434 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 6gs7 chain A Region: 3 - 503 Aligned: 450 Modelled: 452 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:dipeptide and tripeptide permease a; PDBTitle: crystal structure of peptide transporter dtpa-nanobody in glycine2 buffer Phyre2 PDB 4iky chain A Region: 4 - 507 Aligned: 444 Modelled: 444 Confidence: 100.0% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:di-tripeptide abc transporter (permease); PDBTitle: crystal structure of peptide transporter pot (e310q mutant) in complex2 with sulfate Phyre2 PDB 4aps chain B Region: 3 - 411 Aligned: 405 Modelled: 409 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: B: PDB Molecule:di-or tripeptide h+ symporter; PDBTitle: crystal structure of a pot family peptide transporter in an inward2 open conformation. Phyre2 PDB 6h7d chain A Region: 1 - 505 Aligned: 427 Modelled: 427 Confidence: 100.0% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 PDB 2gfp chain A Region: 8 - 418 Aligned: 355 Modelled: 357 Confidence: 100.0% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 4lds chain B Region: 7 - 414 Aligned: 385 Modelled: 386 Confidence: 100.0% Identity: 16% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 6g9x chain B Region: 6 - 503 Aligned: 368 Modelled: 375 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 6ei3 chain A Region: 3 - 506 Aligned: 453 Modelled: 456 Confidence: 100.0% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:proton-dependent oligopeptide transporter family protein; PDBTitle: crystal structure of auto inhibited pot family peptide transporter Phyre2 PDB 5c65 chain A Region: 1 - 505 Aligned: 427 Modelled: 427 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: structure of the human glucose transporter glut3 / slc2a3 Phyre2 PDB 6exs chain A Region: 7 - 503 Aligned: 437 Modelled: 437 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:peptide abc transporter permease; PDBTitle: crystal structure of a pot family transporter in complex with2 thioalcohol conjugated peptide. Phyre2 PDB 4w6v chain A Region: 4 - 503 Aligned: 443 Modelled: 443 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:di-/tripeptide transporter; PDBTitle: crystal structure of a peptide transporter from yersinia2 enterocolitica at 3 a resolution Phyre2 PDB 2xut chain C Region: 10 - 423 Aligned: 412 Modelled: 414 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: C: PDB Molecule:proton/peptide symporter family protein; PDBTitle: crystal structure of a proton dependent oligopeptide (pot) family2 transporter. Phyre2 PDB 3o7p chain A Region: 4 - 415 Aligned: 380 Modelled: 388 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 4gbz chain A Region: 2 - 505 Aligned: 451 Modelled: 451 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:d-xylose-proton symporter; PDBTitle: the structure of the mfs (major facilitator superfamily) proton:xylose2 symporter xyle bound to d-glucose Phyre2 PDB 4pyp chain A Region: 2 - 414 Aligned: 400 Modelled: 400 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: crystal structure of the human glucose transporter glut1 Phyre2 1 d1pw4a_ 2 c4zp0A_ 3 c6e9oA_ 4 c3wdoA_ 5 c4cl5B_ 6 c6gs7A_ 7 c4ikyA_ 8 c4apsB_ 9 c6h7dA_ 10 c2gfpA_ 11 c4ldsB_ 12 c6g9xB_ 13 c6ei3A_ 14 c5c65A_ 15 c6exsA_ 16 c4w6vA_ 17 c2xutC_ 18 c3o7pA_ 19 c4gbzA_ 20 c4pypA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62