1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	K	S	T	V	E	Q	L	S	P	T	R	V	R	I	N	V	E	V	P	F	A	E	L	E	P	D	F	Q	R	A	Y	K	E	L	A	K	Q	V	R	L	P	G	F	R	P	G	K	A	P	A	K	L	L	E	A	R	I	G	R
Secondary structure
SS confidence
Disorder		?	?	?					?	?	?																															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	A	M	L	D	Q	I	V	N	D	A	L	P	S	R	Y	G	Q	A	V	A	E	S	D	V	Q	P	L	G	R	P	N	I	E	V	T	K	K	E	Y	G	Q	D	L	Q	F	T	A	E	V	D	I	R	P	K	I	S	P	P	D
Secondary structure
SS confidence
Disorder																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	S	A	L	T	V	S	V	D	P	I	E	I	G	E	D	D	V	D	A	E	L	Q	S	L	R	T	R	F	G	T	L	T	A	V	D	R	P	V	A	V	G	D	V	V	S	I	D	L	S	A	T	V	D	G	E	D	I	P	N
Secondary structure
SS confidence
Disorder																																?	?	?	?	?	?		?																				?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	A	A	E	G	L	S	H	E	V	G	S	G	R	L	I	A	G	L	D	D	A	V	V	G	L	S	A	D	E	S	R	V	F	T	A	K	L	A	A	G	E	H	A	G	Q	E	A	Q	V	T	V	T	V	R	S	V	K	E	R
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	L	P	E	P	D	D	E	F	A	Q	L	A	S	E	F	D	S	I	D	E	L	R	A	S	L	S	D	Q	V	R	Q	A	K	R	A	Q	Q	A	E	Q	I	R	N	A	T	I	D	A	L	L	E	Q	V	D	V	P	L	P	E
Secondary structure
SS confidence
Disorder																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	Y	V	Q	A	Q	F	D	S	V	L	H	S	A	L	S	G	L	N	H	D	E	A	R	F	N	E	L	L	V	E	Q	G	S	S	R	A	A	F	D	A	E	A	R	T	A	S	E	K	D	V	K	R	Q	L	L	L	D	A	L
Secondary structure
SS confidence
Disorder																					?	?	?	?	?								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	D	E	L	Q	V	Q	V	G	Q	D	D	L	T	E	R	L	V	T	T	S	R	Q	Y	G	I	E	P	Q	Q	L	F	G	Y	L	Q	E	R	N	Q	L	P	T	M	F	A	D	V	R	R	E	L	A	I	R	A	A	V	E	A
Secondary structure
SS confidence
Disorder									?	?															?	?	?	?											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.
Sequence		A	T	V	T	D	S	D	G	N	T	I	D	T	S	E	F	F	G	K	R	V	S	A	G	E	A	E	E	A	E	P	A	D	E	G	A	A	R	A	A	S	D	E	A	T	T
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 47%) Beta strand ( 14%)

Rank Aligned region

PDB 1w26 chain B Region: 1 - 441 Aligned: 427 Modelled: 440 Confidence: 100.0% Identity: 23% PDB header:chaperone Chain: B: PDB Molecule:trigger factor; PDBTitle: trigger factor in complex with the ribosome forms a2 molecular cradle for nascent proteins Phyre2 PDB 1t11 chain A Region: 1 - 384 Aligned: 370 Modelled: 384 Confidence: 100.0% Identity: 25% PDB header:chaperone Chain: A: PDB Molecule:trigger factor; PDBTitle: trigger factor Phyre2 PDB 3gty chain X Region: 1 - 429 Aligned: 408 Modelled: 429 Confidence: 100.0% Identity: 18% PDB header:chaperone/ribosomal protein Chain: X: PDB Molecule:trigger factor; PDBTitle: promiscuous substrate recognition in folding and assembly activities2 of the trigger factor chaperone Phyre2 PDB 1t11 chain A domain 2 Region: 1 - 130 Aligned: 129 Modelled: 130 Confidence: 100.0% Identity: 27% Fold: Ribosome binding domain-like Superfamily: Trigger factor ribosome-binding domain Family: Trigger factor ribosome-binding domain Phyre2 PDB 1w26 chain A domain 2 Region: 1 - 132 Aligned: 131 Modelled: 131 Confidence: 99.9% Identity: 22% Fold: Ribosome binding domain-like Superfamily: Trigger factor ribosome-binding domain Family: Trigger factor ribosome-binding domain Phyre2 PDB 1w26 chain A domain 1 Region: 245 - 441 Aligned: 184 Modelled: 197 Confidence: 99.9% Identity: 16% Fold: Triger factor/SurA peptide-binding domain-like Superfamily: Triger factor/SurA peptide-binding domain-like Family: TF C-terminus Phyre2 PDB 1p9y chain A Region: 1 - 118 Aligned: 117 Modelled: 118 Confidence: 99.9% Identity: 21% Fold: Ribosome binding domain-like Superfamily: Trigger factor ribosome-binding domain Family: Trigger factor ribosome-binding domain Phyre2 PDB 2nsa chain A Region: 255 - 422 Aligned: 162 Modelled: 168 Confidence: 99.9% Identity: 15% PDB header:chaperone Chain: A: PDB Molecule:trigger factor; PDBTitle: structures of and interactions between domains of trigger factor from2 themotoga maritim Phyre2 PDB 1w26 chain A domain 3 Region: 133 - 244 Aligned: 112 Modelled: 112 Confidence: 99.8% Identity: 34% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 2d3o chain 1 Region: 11 - 111 Aligned: 100 Modelled: 101 Confidence: 99.8% Identity: 32% PDB header:ribosome Chain: 1: PDB Molecule:trigger factor; PDBTitle: structure of ribosome binding domain of the trigger factor on the 50s2 ribosomal subunit from d. radiodurans Phyre2 PDB 2nsc chain A Region: 1 - 114 Aligned: 109 Modelled: 114 Confidence: 99.8% Identity: 19% PDB header:chaperone Chain: A: PDB Molecule:trigger factor; PDBTitle: structures of and interactions between domains of trigger factor from2 themotoga maritima Phyre2 PDB 5zr0 chain A Region: 119 - 246 Aligned: 128 Modelled: 128 Confidence: 99.8% Identity: 30% PDB header:chaperone Chain: A: PDB Molecule:maltose-binding periplasmic protein,trigger factor; PDBTitle: solution structure of peptidyl-prolyl cis/trans isomerase domain of2 trigger factor in complex with mbp Phyre2 PDB 1t11 chain A domain 3 Region: 137 - 244 Aligned: 108 Modelled: 108 Confidence: 99.8% Identity: 36% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 1l1p chain A Region: 148 - 246 Aligned: 99 Modelled: 99 Confidence: 99.7% Identity: 33% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 1t11 chain A domain 1 Region: 245 - 381 Aligned: 127 Modelled: 137 Confidence: 99.7% Identity: 13% Fold: Triger factor/SurA peptide-binding domain-like Superfamily: Triger factor/SurA peptide-binding domain-like Family: TF C-terminus Phyre2 PDB 1hxv chain A Region: 159 - 238 Aligned: 80 Modelled: 80 Confidence: 99.5% Identity: 21% PDB header:chaperone Chain: A: PDB Molecule:trigger factor; PDBTitle: ppiase domain of the mycoplasma genitalium trigger factor Phyre2 PDB 1hxv chain A Region: 159 - 238 Aligned: 80 Modelled: 80 Confidence: 99.5% Identity: 21% Fold: FKBP-like Superfamily: FKBP-like Family: FKBP immunophilin/proline isomerase Phyre2 PDB 3prd chain A Region: 159 - 257 Aligned: 99 Modelled: 99 Confidence: 99.0% Identity: 23% PDB header:chaperone, isomerase Chain: A: PDB Molecule:fkbp-type peptidyl-prolyl cis-trans isomerase; PDBTitle: structural analysis of protein folding by the methanococcus jannaschii2 chaperone fkbp26 Phyre2 PDB 4msp chain B Region: 156 - 297 Aligned: 141 Modelled: 142 Confidence: 99.0% Identity: 16% PDB header:isomerase Chain: B: PDB Molecule:peptidyl-prolyl cis-trans isomerase fkbp14; PDBTitle: crystal structure of human peptidyl-prolyl cis-trans isomerase fkbp222 (aka fkbp14) containing two ef-hand motifs Phyre2 PDB 3pr9 chain A Region: 159 - 239 Aligned: 81 Modelled: 81 Confidence: 98.6% Identity: 28% PDB header:chaperone Chain: A: PDB Molecule:fkbp-type peptidyl-prolyl cis-trans isomerase; PDBTitle: structural analysis of protein folding by the methanococcus jannaschii2 chaperone fkbp26 Phyre2 1 c1w26B_ 2 c1t11A_ 3 c3gtyX_ 4 d1t11a2 5 d1w26a2 6 d1w26a1 7 d1p9ya_ 8 c2nsaA_ 9 d1w26a3 10 c2d3o1_ 11 c2nscA_ 12 c5zr0A_ 13 d1t11a3 14 d1l1pa_ 15 d1t11a1 16 c1hxvA_ 17 d1hxva_ 18 c3prdA_ 19 c4mspB_ 20 c3pr9A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129