1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	Q	P	D	I	K	G	S	C	A	S	E	F	T	K	V	R	D	A	F	E	R	N	F	V	L	R	N	E	V	G	A	A	V	A	V	W	V	D	G	D	L	V	V	N	L	W	G	G	S	A	D	A	G	G	T	R	P	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	H	D	T	L	A	T	V	L	S	G	T	K	A	L	T	A	T	C	V	H	Q	L	V	D	R	G	E	L	D	L	H	A	P	V	A	R	Y	W	P	E	F	G	Q	A	G	K	Q	A	I	T	L	A	M	V	M	S	H	R	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	A	I	G	P	R	G	R	L	G	W	E	Q	V	A	D	W	D	F	V	C	E	Q	L	A	A	A	E	P	W	W	Q	P	G	A	A	Q	G	Y	H	M	T	T	F	G	F	I	L	G	E	V	F	R	R	V	T	G	R	T	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	Q	Y	L	R	T	E	I	A	E	P	L	G	A	D	V	H	I	G	L	H	P	G	E	Q	L	R	C	A	D	L	V	D	K	P	H	I	R	Q	L	L	A	D	V	Q	A	P	G	Y	P	T	S	L	N	E	H	P	K	A	A
Secondary structure
SS confidence
Disorder																																						?	?	?				?	?		?	?			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	S	V	S	M	G	F	A	P	D	D	E	L	G	S	N	D	L	Q	L	W	R	Q	I	E	F	P	G	T	N	G	Q	V	S	A	L	G	L	A	T	F	Y	N	G	L	A	Q	E	K	L	L	S	R	E	H	M	E	L	V	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?			?	?	?	?															?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	S	Q	G	G	F	D	T	D	L	V	L	G	P	R	V	A	D	H	G	W	G	L	G	Y	M	L	N	Q	R	G	V	N	G	P	N	P	R	I	F	G	H	G	G	L	G	G	S	F	G	F	V	D	L	E	H	R	I	G	Y
Secondary structure
SS confidence
Disorder			?			?	?	?	?	?	?	?		?		?															?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.
Sequence		A	Y	V	M	N	R	F	D	A	T	K	A	N	A	D	P	R	S	V	V	L	S	N	E	V	Y	A	A	L	G	V	N	R	S
Secondary structure
SS confidence
Disorder										?	?	?	?																	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 33%) Beta strand ( 13%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 5gkv chain A Region: 4 - 389 Aligned: 364 Modelled: 369 Confidence: 100.0% Identity: 38% PDB header:hydrolase Chain: A: PDB Molecule:esterase a; PDBTitle: crystal structure of a novel penicillin-binding protein (pbp) homolog2 from caulobacter crescentus Phyre2 PDB 3zyt chain A Region: 6 - 389 Aligned: 358 Modelled: 384 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:esterase a; PDBTitle: structure determination of esta from arthrobacter nitroguajacolicus2 rue61a Phyre2 PDB 5gmx chain A Region: 5 - 389 Aligned: 360 Modelled: 355 Confidence: 100.0% Identity: 40% PDB header:hydrolase Chain: A: PDB Molecule:carboxylesterase; PDBTitle: crystal structure of a family viii carboxylesterase Phyre2 PDB 4ivk chain A Region: 2 - 391 Aligned: 354 Modelled: 360 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:carboxylesterases; PDBTitle: crystal structure of a fammily viii carboxylesterase in a complex with2 cephalothin. Phyre2 PDB 4p6b chain B Region: 15 - 389 Aligned: 348 Modelled: 354 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:est-y29; PDBTitle: crystal structure of est-y29,a novel penicillin-binding protein/beta-2 lactamase homolog from a metagenomic library Phyre2 PDB 3hle chain A Region: 1 - 389 Aligned: 361 Modelled: 363 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:transesterase; PDBTitle: simvastatin synthase (lovd), from aspergillus terreus, s5 mutant, s76a2 mutant, complex with monacolin j acid Phyre2 PDB 2qmi chain H Region: 14 - 386 Aligned: 325 Modelled: 337 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: H: PDB Molecule:pbp related beta-lactamase; PDBTitle: structure of the octameric penicillin-binding protein2 homologue from pyrococcus abyssi Phyre2 PDB 1ci9 chain A Region: 10 - 387 Aligned: 357 Modelled: 361 Confidence: 100.0% Identity: 24% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 2drw chain A domain 1 Region: 15 - 394 Aligned: 352 Modelled: 365 Confidence: 100.0% Identity: 20% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1ei5 chain A Region: 14 - 386 Aligned: 316 Modelled: 333 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:d-aminopeptidase; PDBTitle: crystal structure of a d-aminopeptidase from ochrobactrum2 anthropi Phyre2 PDB 5tgf chain B Region: 14 - 389 Aligned: 312 Modelled: 313 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of putative beta-lactamase from bacteroides dorei2 dsm 17855 Phyre2 PDB 1onh chain A Region: 8 - 389 Aligned: 330 Modelled: 345 Confidence: 100.0% Identity: 22% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 1rgy chain A Region: 15 - 389 Aligned: 320 Modelled: 329 Confidence: 100.0% Identity: 20% Fold: beta-lactamase/transpeptidase-like Superfamily: beta-lactamase/transpeptidase-like Family: beta-Lactamase/D-ala carboxypeptidase Phyre2 PDB 2qz6 chain A Region: 15 - 389 Aligned: 321 Modelled: 338 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: first crystal structure of a psychrophile class c beta-2 lactamase Phyre2 PDB 3ws1 chain A Region: 15 - 390 Aligned: 328 Modelled: 335 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: n288q-n321q mutant beta-lactamase derived from chromohalobacter sp.5602 (condition-1b) Phyre2 PDB 5e2h chain B Region: 14 - 389 Aligned: 325 Modelled: 336 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of d-alanine carboxypeptidase ampc from2 mycobacterium smegmatis Phyre2 PDB 2wzz chain A Region: 11 - 389 Aligned: 325 Modelled: 335 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:beta-lactamase; PDBTitle: amp-c beta-lactamase (pseudomonas aeruginosa)in complex2 with compound m-03 Phyre2 PDB 3o3v chain B Region: 15 - 393 Aligned: 328 Modelled: 345 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:beta-lactamase; PDBTitle: crystal structure of clbp peptidase domain Phyre2 PDB 4y7p chain A Region: 14 - 385 Aligned: 326 Modelled: 342 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:alkaline d-peptidase; PDBTitle: structure of alkaline d-peptidase from bacillus cereus Phyre2 PDB 5zh8 chain B Region: 3 - 393 Aligned: 327 Modelled: 350 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:protein fmta; PDBTitle: crystal structure of fmta from staphylococcus aureus at 2.58 a Phyre2 1 c5gkvA_ 2 c3zytA_ 3 c5gmxA_ 4 c4ivkA_ 5 c4p6bB_ 6 c3hleA_ 7 c2qmiH_ 8 d1ci9a_ 9 d2drwa1 10 c1ei5A_ 11 c5tgfB_ 12 d1onha_ 13 d1rgya_ 14 c2qz6A_ 15 c3ws1A_ 16 c5e2hB_ 17 c2wzzA_ 18 c3o3vB_ 19 c4y7pA_ 20 c5zh8B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185