1

.

.

.

.

.

.

.

.

10

.

.

.

.

.

.

.

.

.

20

.

.

.

.

.

.

.

.

.

30

.

.

.

.

.

.

.

.

.

40

.

.

.

.

.

.

.

.

.

50

.

.

.

.

.

.

.

.

.

60

Sequence

M

E

I

H

L

F

F

V

G

I

P

L

L

L

V

V

V

L

S

V

L

I

W

S

R

K

G

P

H

P

A

T

Y

K

L

S

E

P

W

T

H

P

P

I

L

W

A

A

T

D

E

V

V

G

S

A

H

G

G

H

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

.

.

.

.

.

.

.

Sequence

G

H

D

A

S

E

F

T

V

G

G

G

A

S

G

T

W

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 48%) Alpha helix ( 25%) Beta strand ( 19%) TM helix ( 21%) (View membrane topology prediction)

Rank Aligned region

PDB 6adq chain I Region: 3 - 77 Aligned: 62 Modelled: 74 Confidence: 99.9% Identity: 56% PDB header:electron transport Chain: I: PDB Molecule:cytochrome c oxidase subunit ctaj; PDBTitle: respiratory complex ciii2civ2sod2 from mycobacterium smegmatis Phyre2 PDB 6hwh chain R Region: 3 - 50 Aligned: 48 Modelled: 48 Confidence: 99.6% Identity: 56% PDB header:electron transport Chain: R: PDB Molecule:msmeg_4693; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 1fft chain B domain 2 Region: 5 - 23 Aligned: 19 Modelled: 19 Confidence: 23.0% Identity: 32% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 6hu9 chain E Region: 6 - 39 Aligned: 34 Modelled: 34 Confidence: 19.5% Identity: 12% PDB header:oxidoreductase/electron transport Chain: E: PDB Molecule:cytochrome b-c1 complex subunit rieske, mitochondrial; PDBTitle: iii2-iv2 mitochondrial respiratory supercomplex from s. cerevisiae Phyre2 PDB 6h3w chain A Region: 13 - 40 Aligned: 28 Modelled: 28 Confidence: 17.1% Identity: 25% PDB header:viral protein Chain: A: PDB Molecule:envelopment polyprotein; PDBTitle: la crosse virus glycoprotein gc head domain Phyre2 PDB 6e3y chain E Region: 2 - 21 Aligned: 20 Modelled: 20 Confidence: 14.8% Identity: 20% PDB header:signaling protein Chain: E: PDB Molecule:receptor activity-modifying protein 1; PDBTitle: cryo-em structure of the active, gs-protein complexed, human cgrp2 receptor Phyre2 PDB 1gph chain 1 domain 1 Region: 5 - 45 Aligned: 41 Modelled: 41 Confidence: 12.0% Identity: 20% Fold: PRTase-like Superfamily: PRTase-like Family: Phosphoribosyltransferases (PRTases) Phyre2 PDB 3nk4 chain C Region: 42 - 61 Aligned: 14 Modelled: 20 Confidence: 10.4% Identity: 36% PDB header:cell adhesion Chain: C: PDB Molecule:zona pellucida 3; PDBTitle: crystal structure of full-length sperm receptor zp3 at 2.0 a2 resolution Phyre2 PDB 3nk3 chain C Region: 42 - 61 Aligned: 14 Modelled: 20 Confidence: 10.3% Identity: 36% PDB header:cell adhesion Chain: C: PDB Molecule:zona pellucida 3; PDBTitle: crystal structure of full-length sperm receptor zp3 at 2.6 a2 resolution Phyre2 PDB 2ges chain A Region: 70 - 76 Aligned: 7 Modelled: 7 Confidence: 10.2% Identity: 43% PDB header:transferase Chain: A: PDB Molecule:pantothenate kinase; PDBTitle: pantothenate kinase from mycobacterium tuberculosis (mtpank) in2 complex with a coenzyme a derivative, form-i (rt) Phyre2 PDB 2iif chain A Region: 49 - 62 Aligned: 14 Modelled: 14 Confidence: 10.0% Identity: 36% PDB header:recombination/dna Chain: A: PDB Molecule:integration host factor; PDBTitle: single chain integration host factor mutant protein (scihf2-k45ae) in2 complex with dna Phyre2 PDB 3tqc chain B Region: 70 - 76 Aligned: 7 Modelled: 7 Confidence: 9.5% Identity: 43% PDB header:transferase Chain: B: PDB Molecule:pantothenate kinase; PDBTitle: structure of the pantothenate kinase (coaa) from coxiella burnetii Phyre2 PDB 2lfw chain A Region: 48 - 62 Aligned: 15 Modelled: 15 Confidence: 9.2% Identity: 33% PDB header:signaling protein Chain: A: PDB Molecule:phyr sigma-like domain; PDBTitle: nmr structure of the phyrsl-nepr complex from sphingomonas sp. fr1 Phyre2 PDB 1o9a chain A domain 1 Region: 31 - 42 Aligned: 12 Modelled: 12 Confidence: 9.1% Identity: 17% Fold: FnI-like domain Superfamily: FnI-like domain Family: Fibronectin type I module Phyre2 PDB 3vu1 chain A Region: 44 - 63 Aligned: 20 Modelled: 20 Confidence: 8.7% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein ph0242; PDBTitle: crystal structure of the c-terminal globular domain of2 oligosaccharyltransferase (phaglb-l, o74088_pyrho) from pyrococcus3 horikoshii Phyre2 PDB 1sq5 chain A Region: 70 - 76 Aligned: 7 Modelled: 7 Confidence: 8.7% Identity: 43% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Phosphoribulokinase/pantothenate kinase Phyre2 PDB 2cg7 chain A domain 2 Region: 32 - 42 Aligned: 11 Modelled: 11 Confidence: 8.2% Identity: 27% Fold: FnI-like domain Superfamily: FnI-like domain Family: Fibronectin type I module Phyre2 PDB 2bzw chain B Region: 42 - 48 Aligned: 7 Modelled: 7 Confidence: 7.8% Identity: 86% PDB header:transcription Chain: B: PDB Molecule:bcl2-antagonist of cell death; PDBTitle: the crystal structure of bcl-xl in complex with full-length bad Phyre2 PDB 3c8u chain A Region: 68 - 76 Aligned: 9 Modelled: 9 Confidence: 7.3% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:fructokinase; PDBTitle: crystal structure of putative fructose transport system kinase2 (yp_612366.1) from silicibacter sp. tm1040 at 1.95 a resolution Phyre2 PDB 2ec3 chain A Region: 32 - 41 Aligned: 10 Modelled: 10 Confidence: 6.4% Identity: 40% PDB header:cell adhesion Chain: A: PDB Molecule:fibronectin; PDBTitle: solution structure of the 11th fn1 domain from human2 fibronectin 1 Phyre2 1 c6adqI_ 2 c6hwhR_ 3 d1fftb2 4 c6hu9e_ 5 c6h3wA_ 6 c6e3yE_ 7 d1gph11 8 c3nk4C_ 9 c3nk3C_ 10 c2gesA_ 11 c2iifA_ 12 c3tqcB_ 13 c2lfwA_ 14 d1o9aa1 15 c3vu1A_ 16 d1sq5a_ 17 d2cg7a2 18 c2bzwB_ 19 c3c8uA_ 20 c2ec3A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34