1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	M	M	R	I	A	V	R	L	P	G	E	V	I	T	F	V	D	S	E	V	S	Q	I	R	I	P	S	R	R	A	A	V	V	L	R	A	S	N	A	S	D	A	A	I	L	T	A	T	E	P	N	H	H	L	D	A	L	A	G
Secondary structure
SS confidence
Disorder		?	?	?				?																							?																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.
Sequence		Q	A	A	K	L	A	P	T	S	I	D	A	A	H	P	A	R	P	A	R	R	D	P	C	L	Y	P	R	T	G	Q	A	L	P	R	T	G
Secondary structure
SS confidence
Disorder		?						?	?		?	?	?	?	?	?	?	?	?	?												?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 27%) Alpha helix ( 7%) Beta strand ( 38%)

Rank Aligned region

PDB 2bj7 chain A domain 1 Region: 2 - 29 Aligned: 28 Modelled: 28 Confidence: 26.1% Identity: 18% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2ca9 chain B Region: 2 - 29 Aligned: 28 Modelled: 28 Confidence: 17.3% Identity: 21% PDB header:transcription Chain: B: PDB Molecule:putative nickel-responsive regulator; PDBTitle: apo-nikr from helicobacter pylori in closed trans-2 conformation Phyre2 PDB 5l6m chain A Region: 6 - 41 Aligned: 33 Modelled: 36 Confidence: 16.2% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:vapb family protein; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 1r53 chain A Region: 77 - 88 Aligned: 12 Modelled: 12 Confidence: 15.3% Identity: 42% Fold: Chorismate synthase, AroC Superfamily: Chorismate synthase, AroC Family: Chorismate synthase, AroC Phyre2 PDB 6nkl chain D Region: 6 - 26 Aligned: 20 Modelled: 21 Confidence: 13.4% Identity: 35% PDB header:antitoxin Chain: D: PDB Molecule:antitoxin vapb1; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 1v8c chain A domain 2 Region: 8 - 33 Aligned: 26 Modelled: 26 Confidence: 13.2% Identity: 46% Fold: TBP-like Superfamily: MoaD-related protein, C-terminal domain Family: MoaD-related protein, C-terminal domain Phyre2 PDB 4lj2 chain A Region: 35 - 88 Aligned: 48 Modelled: 54 Confidence: 12.7% Identity: 29% PDB header:lyase Chain: A: PDB Molecule:chorismate synthase; PDBTitle: crystal structure of chorismate synthase from acinetobacter baumannii2 at 3.15a resolution Phyre2 PDB 5l6l chain D Region: 6 - 41 Aligned: 33 Modelled: 36 Confidence: 12.7% Identity: 36% PDB header:hydrolase Chain: D: PDB Molecule:vapb family protein; PDBTitle: structure of caulobacter crescentus vapbc1 bound to operator dna Phyre2 PDB 3tnd chain F Region: 6 - 41 Aligned: 33 Modelled: 36 Confidence: 12.2% Identity: 24% PDB header:translation, toxin Chain: F: PDB Molecule:antitoxin vapb; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 1q5v chain B Region: 2 - 29 Aligned: 28 Modelled: 28 Confidence: 10.8% Identity: 21% PDB header:transcription Chain: B: PDB Molecule:nickel responsive regulator; PDBTitle: apo-nikr Phyre2 PDB 2bj3 chain D Region: 2 - 29 Aligned: 28 Modelled: 28 Confidence: 10.3% Identity: 18% PDB header:transcription Chain: D: PDB Molecule:nickel responsive regulator; PDBTitle: nikr-apo Phyre2 PDB 3zvk chain G Region: 6 - 41 Aligned: 32 Modelled: 36 Confidence: 8.8% Identity: 44% PDB header:antitoxin/toxin/dna Chain: G: PDB Molecule:antitoxin of toxin-antitoxin system vapb; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 3ms6 chain A Region: 57 - 73 Aligned: 17 Modelled: 17 Confidence: 8.5% Identity: 47% PDB header:protein binding Chain: A: PDB Molecule:hepatitis b virus x-interacting protein; PDBTitle: crystal structure of hepatitis b x-interacting protein (hbxip) Phyre2 PDB 1sq1 chain A Region: 66 - 88 Aligned: 23 Modelled: 23 Confidence: 8.1% Identity: 26% Fold: Chorismate synthase, AroC Superfamily: Chorismate synthase, AroC Family: Chorismate synthase, AroC Phyre2 PDB 1p9q chain C domain 3 Region: 3 - 12 Aligned: 10 Modelled: 10 Confidence: 8.0% Identity: 50% Fold: Ferredoxin-like Superfamily: EF-G C-terminal domain-like Family: Hypothetical protein AF0491, C-terminal domain Phyre2 PDB 1rdu chain A Region: 2 - 12 Aligned: 11 Modelled: 11 Confidence: 7.7% Identity: 36% Fold: Ribonuclease H-like motif Superfamily: Nitrogenase accessory factor-like Family: MTH1175-like Phyre2 PDB 2wfb chain A Region: 2 - 7 Aligned: 6 Modelled: 6 Confidence: 6.8% Identity: 83% PDB header:biosynthetic protein Chain: A: PDB Molecule:putative uncharacterized protein orp; PDBTitle: high resolution structure of the apo form of the orange2 protein (orp) from desulfovibrio gigas Phyre2 PDB 5z2f chain A Region: 1 - 7 Aligned: 7 Modelled: 7 Confidence: 6.1% Identity: 57% PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrodipicolinate reductase; PDBTitle: nadph/pda bound dihydrodipicolinate reductase from paenisporosarcina2 sp. tg-14 Phyre2 PDB 4ubp chain B Region: 9 - 45 Aligned: 33 Modelled: 37 Confidence: 5.8% Identity: 36% Fold: beta-clip Superfamily: Urease, beta-subunit Family: Urease, beta-subunit Phyre2 PDB 1ejx chain B Region: 9 - 45 Aligned: 33 Modelled: 37 Confidence: 5.7% Identity: 30% Fold: beta-clip Superfamily: Urease, beta-subunit Family: Urease, beta-subunit Phyre2 1 d2bj7a1 2 c2ca9B_ 3 c5l6mA_ 4 d1r53a_ 5 c6nklD_ 6 d1v8ca2 7 c4lj2A_ 8 c5l6lD_ 9 c3tndF_ 10 c1q5vB_ 11 c2bj3D_ 12 c3zvkG_ 13 c3ms6A_ 14 d1sq1a_ 15 d1p9qc3 16 d1rdua_ 17 c2wfbA_ 18 c5z2fA_ 19 d4ubpb_ 20 d1ejxb_