Phyre 2 Results for RVBD2476c_(gdh)_2777398

Email	mdejesus@rockefeller.edu
Description	RVBD2476c_(gdh)_2777398_2782272
Date	Wed Aug 7 12:50:10 BST 2019
Unique Job ID	06b9169357dad32c
Sequence	MTIDPGAKQD ... Download FASTA
Job Type	normal
Job Expiry

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:73.514 Y:65.950 Z:65.201

Model (left) based on template c1hrdA_

Top template information

PDB header:oxidoreductase
Chain: A: PDB Molecule:glutamate dehydrogenase;
PDBTitle: glutamate dehydrogenase

Confidence and coverage

Confidence:

100.0%

Coverage:

27%

436 residues ( 27% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

540 residues ( 33%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in JSmol

For other options to view your downloaded structure offline see the FAQ

Sequence analysis

Download FASTA version

Secondary structure and disorder prediction [Show]

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M T I D P G A K Q D V E A W T T F T A S A D I P D W I S K A Y I D S Y R G P R D D S S E A T K A A E A S W L P A S L L T

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ?
?
? ? ?
? ? ? ? ? ? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence P A M L G A H Y R L G R H R A A G E S C V A V Y R A D D P A G F G P A L Q V V A E H G G M L M D S V T V L L H R L G I A

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence Y A A I L T P V F D V H R S P T G E L L R I E P K A E G T S P H L G E A W M H V A L S P A V D H K G L A E V E R L L P K

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence V L A D V Q R V A T D A T A L I A T L S E L A G E V E S N A G G R F S A P D R Q D V G E L L R W L G D G N F L L L G Y Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence R C R V A D G M V Y G E G S S G M G V L R G R T G S R P R L T D D D K L L V L A Q A R V G S Y L R Y G A Y P Y A I A V R

Secondary structure

SS confidence

Disorder
? ?
? ? ? ? ? ?
? ?
? ? ?
? ?
? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence E Y V D G S V V E H R F V G L F S V A A M N A D V L E I P T I S R R V R E A L A M A E S D P S H P G Q L L L D V I Q T V

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence P R P E L F T L S A Q R L L T M A R A V V D L G S Q R Q A L L F L R A D R L Q Y F V S C L V Y M P R D R Y T T A V R M Q

Secondary structure

SS confidence

Disorder
? ? ?
?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence F E D I L V R E F G G T R L E F T A R V S E S P W A L M H F M V R L P E V G V A G E G A A A P P V D V S E A N R I R I Q

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence G L L T E A A R T W A D R L I G A A A A A G S V G Q A D A M H Y A A A F S E A Y K Q A V T P A D A I G D I A V I T E L T

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence D D S V K L V F S E R D E Q G V A Q L T W F L G G R T A S L S Q L L P M L Q S M G V V V L E E R P F S V T R P D G L P V

Secondary structure

SS confidence

Disorder
?
? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence W I Y Q F K I S P H P T I P L A P T V A E R A A T A H R F A E A V T A I W H G R V E I D R F N E L V M R A G L T W Q Q V

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence V L L R A Y A K Y L R Q A G F P Y S Q S Y I E S V L N E H P A T V R S L V D L F E A L F V P V P S G S A S N R D A Q A A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence A A A V A A D I D A L V S L D T D R I L R A F A S L V Q A T L R T N Y F V T R Q G S A R C R D V L A L K L N A Q L I D E

Secondary structure

SS confidence

Disorder
?
?
? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence L P L P R P R Y E I F V Y S P R V E G V H L R F G P V A R G G L R W S D R R D D F R T E I L G L V K A Q A V K N A V I V

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence P V G A K G G F V V K R P P L P T G D P A A D R D A T R A E G V A C Y Q L F I S G L L D V T D N V D H A T A S V N P P P

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
?
? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence E V V R R D G D D A Y L V V A A D K G T A T F S D I A N D V A K S Y G F W L G D A F A S G G S V G Y D H K A M G I T A R

Secondary structure

SS confidence

Disorder
?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence G A W E A V K R H F R E I G I D T Q T Q D F T V V G I G D M S G D V F G N G M L L S K H I R L I A A F D H R H I F L D P

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence N P D A A V S W A E R R R M F E L P R S S W S D Y D R S L I S E G G G V Y S R E Q K A I P L S A Q V R A V L G I D G S V

Secondary structure

SS confidence

Disorder
?
?
? ? ?
?
? ?
?

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence D G G A A E M A P P N L I R A I L R A P V D L L F N G G I G T Y I K A E S E S D A D V G D R A N D P V R V N A N Q V R A

Secondary structure

SS confidence

Disorder ? ? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence K V I G E G G N L G V T A L G R V E F D L S G G R I N T D A L D N S A G V D C S D H E V N I K I L I D S L V S A G T V K

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence A D E R T Q L L E S M T D E V A Q L V L A D N E D Q N D L M G T S R A N A A S L L P V H A M Q I K Y L V A E R G V N R E

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
? ?
?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence L E A L P S E K E I A R R S E A G I G L T S P E L A T L M A H V K L G L K E E V L A T E L P D Q D V F A S R L P R Y F P

Secondary structure

SS confidence

Disorder
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence T A L R E R F T P E I R S H Q L R R E I V T T M L I N D L V D T A G I T Y A F R I A E D V G V T P I D A V R T Y V A T D

Secondary structure

SS confidence

Disorder
?
? ?

Disorder confidence

. . . . . . . . . 1390 . . . . . . . . . 1400 . . . . . . . . . 1410 . . . . . . . . . 1420 . . . . . . . . . 1430 . . . . . . . . . 1440

Sequence A I F G V G H I W R R I R A A N L P I A L S D R L T L D T R R L I D R A G R W L L N Y R P Q P L A V G A E I N R F A A M

Secondary structure

SS confidence

Disorder
?
?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1450 . . . . . . . . . 1460 . . . . . . . . . 1470 . . . . . . . . . 1480 . . . . . . . . . 1490 . . . . . . . . . 1500

Sequence V K A L T P R M S E W L R G D D K A I V E K T A A E F A S Q G V P E D L A Y R V S T G L Y R Y S L L D I I D I A D I A D

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 1510 . . . . . . . . . 1520 . . . . . . . . . 1530 . . . . . . . . . 1540 . . . . . . . . . 1550 . . . . . . . . . 1560

Sequence I D A A E V A D T Y F A L M D R L G T D G L L T A V S Q L P R H D R W H S L A R L A I R D D I Y G A L R S L C F D V L A

Secondary structure

SS confidence

Disorder
? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1570 . . . . . . . . . 1580 . . . . . . . . . 1590 . . . . . . . . . 1600 . . . . . . . . . 1610 . . . . . . . . . 1620

Sequence V G E P G E S S E Q K I A E W E H L S A S R V A R A R R T L D D I R A S G Q K D L A T L S V A A R Q I R R M T R T S G R

Secondary structure

SS confidence

Disorder ?
? ?
?
? ? ? ?
? ? ? ? ?

Disorder confidence

. . . .

Sequence G I S G

Secondary structure

SS confidence

Disorder ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 13%)

Alpha helix ( 51%)

Beta strand ( 13%)

Domain analysis [Show]

Rank Aligned region

PDB 1hrd chain A

3D model

Region: 691 - 1255
Aligned: 436
Modelled: 481
Confidence: 100.0%
Identity: 18%
PDB header:oxidoreductase
Chain: A: PDB Molecule:glutamate dehydrogenase;
PDBTitle: glutamate dehydrogenase

Phyre2

PDB 3r3j chain C

Region: 720 - 1257
Aligned: 430
Modelled: 478
Confidence: 100.0%
Identity: 17%
PDB header:oxidoreductase
Chain: C: PDB Molecule:glutamate dehydrogenase;
PDBTitle: kinetic and structural characterization of plasmodium falciparum2 glutamate dehydrogenase 2

Phyre2

PDB 1nr1 chain A

3D model

Region: 720 - 1253
Aligned: 430
Modelled: 461
Confidence: 100.0%
Identity: 23%
PDB header:oxidoreductase
Chain: A: PDB Molecule:glutamate dehydrogenase 1;
PDBTitle: crystal structure of the r463a mutant of human glutamate dehydrogenase

Phyre2

PDB 2bma chain A

3D model

Region: 728 - 1255
Aligned: 423
Modelled: 475
Confidence: 100.0%
Identity: 17%
PDB header:oxidoreductase
Chain: A: PDB Molecule:glutamate dehydrogenase (nadp+);
PDBTitle: the crystal structure of plasmodium falciparum glutamate2 dehydrogenase, a putative target for novel antimalarial3 drugs

Phyre2

PDB 2tmg chain D

3D model

Region: 771 - 1247
Aligned: 375
Modelled: 400
Confidence: 100.0%
Identity: 23%
PDB header:oxidoreductase
Chain: D: PDB Molecule:protein (glutamate dehydrogenase);
PDBTitle: thermotoga maritima glutamate dehydrogenase mutant s128r,2 t158e, n117r, s160e

Phyre2

PDB 1bvu chain F

3D model

Region: 771 - 1259
Aligned: 378
Modelled: 402
Confidence: 100.0%
Identity: 22%
PDB header:oxidoreductase
Chain: F: PDB Molecule:protein (glutamate dehydrogenase);
PDBTitle: glutamate dehydrogenase from thermococcus litoralis

Phyre2

PDB 5ijz chain H

3D model

Region: 690 - 1257
Aligned: 435
Modelled: 494
Confidence: 100.0%
Identity: 20%
PDB header:oxidoreductase
Chain: H: PDB Molecule:nadp-specific glutamate dehydrogenase;
PDBTitle: crystal strcuture of glutamate dehydrogenase(gdh) from corynebacterium2 glutamicum

Phyre2

PDB 3aoe chain C

3D model

Region: 771 - 1256
Aligned: 374
Modelled: 405
Confidence: 100.0%
Identity: 21%
PDB header:oxidoreductase
Chain: C: PDB Molecule:glutamate dehydrogenase;
PDBTitle: crystal structure of hetero-hexameric glutamate dehydrogenase from2 thermus thermophilus (leu bound form)

Phyre2

PDB 3sbo chain A

3D model

Region: 724 - 1257
Aligned: 426
Modelled: 467
Confidence: 100.0%
Identity: 18%
PDB header:oxidoreductase
Chain: A: PDB Molecule:nadp-specific glutamate dehydrogenase;
PDBTitle: structure of e.coli gdh from native source

Phyre2

PDB 4xgi chain A

3D model

Region: 771 - 1257
Aligned: 373
Modelled: 410
Confidence: 100.0%
Identity: 23%
PDB header:oxidoreductase
Chain: A: PDB Molecule:glutamate dehydrogenase;
PDBTitle: crystal structure of glutamate dehydrogenase from burkholderia2 thailandensis

Phyre2

PDB 2yfq chain A

3D model

Region: 773 - 1255
Aligned: 354
Modelled: 380
Confidence: 100.0%
Identity: 23%
PDB header:oxidoreductase
Chain: A: PDB Molecule:nad-specific glutamate dehydrogenase;
PDBTitle: crystal structure of glutamate dehydrogenase from2 peptoniphilus asaccharolyticus

Phyre2

PDB 1v9l chain A

3D model

Region: 785 - 1257
Aligned: 372
Modelled: 401
Confidence: 100.0%
Identity: 22%
PDB header:oxidoreductase
Chain: A: PDB Molecule:glutamate dehydrogenase;
PDBTitle: l-glutamate dehydrogenase from pyrobaculum islandicum2 complexed with nad

Phyre2

PDB 3aog chain A

3D model

Region: 771 - 1260
Aligned: 381
Modelled: 405
Confidence: 100.0%
Identity: 21%
PDB header:oxidoreductase
Chain: A: PDB Molecule:glutamate dehydrogenase;
PDBTitle: crystal structure of glutamate dehydrogenase (gdhb) from thermus2 thermophilus (glu bound form)

Phyre2

PDB 3k8z chain D

3D model

Region: 772 - 1257
Aligned: 347
Modelled: 375
Confidence: 100.0%
Identity: 23%
PDB header:oxidoreductase
Chain: D: PDB Molecule:nad-specific glutamate dehydrogenase;
PDBTitle: crystal structure of gudb1 a decryptified secondary glutamate2 dehydrogenase from b. subtilis

Phyre2

PDB 5xvi chain A

3D model

Region: 797 - 1255
Aligned: 365
Modelled: 410
Confidence: 100.0%
Identity: 19%
PDB header:oxidoreductase
Chain: A: PDB Molecule:glutamate dehydrogenase;
PDBTitle: crystal structure of aspergillus niger apo- glutamate dehydrogenase

Phyre2

PDB 1bxg chain A

3D model

Region: 800 - 1249
Aligned: 312
Modelled: 352
Confidence: 100.0%
Identity: 22%
PDB header:amino acid dehydrogenase
Chain: A: PDB Molecule:phenylalanine dehydrogenase;
PDBTitle: phenylalanine dehydrogenase structure in ternary complex2 with nad+ and beta-phenylpropionate

Phyre2

PDB 1bvu chain A domain 1

3D model

Region: 945 - 1259
Aligned: 238
Modelled: 253
Confidence: 100.0%
Identity: 22%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: Aminoacid dehydrogenase-like, C-terminal domain

Phyre2

PDB 1leh chain B

3D model

Region: 797 - 1264
Aligned: 327
Modelled: 383
Confidence: 100.0%
Identity: 24%
PDB header:oxidoreductase
Chain: B: PDB Molecule:leucine dehydrogenase;
PDBTitle: leucine dehydrogenase from bacillus sphaericus

Phyre2

PDB 1b26 chain A domain 1

3D model

Region: 945 - 1255
Aligned: 234
Modelled: 253
Confidence: 100.0%
Identity: 23%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: Aminoacid dehydrogenase-like, C-terminal domain

Phyre2

PDB 1euz chain A domain 1

3D model

Region: 945 - 1259
Aligned: 238
Modelled: 257
Confidence: 99.9%
Identity: 22%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: Aminoacid dehydrogenase-like, C-terminal domain

Phyre2

1
c1hrdA_

2
c3r3jC_

3
c1nr1A_

4
c2bmaA_

5
c2tmgD_

6
c1bvuF_

7
c5ijzH_

8
c3aoeC_

9
c3sboA_

10
c4xgiA_

11
c2yfqA_

12
c1v9lA_

13
c3aogA_

14
c3k8zD_

15
c5xviA_

16
c1bxgA_

17
d1bvua1

18
c1lehB_

19
d1b26a1

20
d1euza1

21

22

23

24

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26

27

28

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157

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	T	I	D	P	G	A	K	Q	D	V	E	A	W	T	T	F	T	A	S	A	D	I	P	D	W	I	S	K	A	Y	I	D	S	Y	R	G	P	R	D	D	S	S	E	A	T	K	A	A	E	A	S	W	L	P	A	S	L	L	T
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?		?						?	?	?															?	?	?	?	?	?	?	?	?							?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	P	A	M	L	G	A	H	Y	R	L	G	R	H	R	A	A	G	E	S	C	V	A	V	Y	R	A	D	D	P	A	G	F	G	P	A	L	Q	V	V	A	E	H	G	G	M	L	M	D	S	V	T	V	L	L	H	R	L	G	I	A
Secondary structure
SS confidence
Disorder													?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	Y	A	A	I	L	T	P	V	F	D	V	H	R	S	P	T	G	E	L	L	R	I	E	P	K	A	E	G	T	S	P	H	L	G	E	A	W	M	H	V	A	L	S	P	A	V	D	H	K	G	L	A	E	V	E	R	L	L	P	K
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?	?	?														?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	V	L	A	D	V	Q	R	V	A	T	D	A	T	A	L	I	A	T	L	S	E	L	A	G	E	V	E	S	N	A	G	G	R	F	S	A	P	D	R	Q	D	V	G	E	L	L	R	W	L	G	D	G	N	F	L	L	L	G	Y	Q
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	R	C	R	V	A	D	G	M	V	Y	G	E	G	S	S	G	M	G	V	L	R	G	R	T	G	S	R	P	R	L	T	D	D	D	K	L	L	V	L	A	Q	A	R	V	G	S	Y	L	R	Y	G	A	Y	P	Y	A	I	A	V	R
Secondary structure
SS confidence
Disorder							?	?		?	?	?	?	?	?										?	?			?	?	?												?	?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	E	Y	V	D	G	S	V	V	E	H	R	F	V	G	L	F	S	V	A	A	M	N	A	D	V	L	E	I	P	T	I	S	R	R	V	R	E	A	L	A	M	A	E	S	D	P	S	H	P	G	Q	L	L	L	D	V	I	Q	T	V
Secondary structure
SS confidence
Disorder																																												?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	P	R	P	E	L	F	T	L	S	A	Q	R	L	L	T	M	A	R	A	V	V	D	L	G	S	Q	R	Q	A	L	L	F	L	R	A	D	R	L	Q	Y	F	V	S	C	L	V	Y	M	P	R	D	R	Y	T	T	A	V	R	M	Q
Secondary structure
SS confidence
Disorder																						?	?	?					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	F	E	D	I	L	V	R	E	F	G	G	T	R	L	E	F	T	A	R	V	S	E	S	P	W	A	L	M	H	F	M	V	R	L	P	E	V	G	V	A	G	E	G	A	A	A	P	P	V	D	V	S	E	A	N	R	I	R	I	Q
Secondary structure
SS confidence
Disorder															?																						?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	G	L	L	T	E	A	A	R	T	W	A	D	R	L	I	G	A	A	A	A	A	G	S	V	G	Q	A	D	A	M	H	Y	A	A	A	F	S	E	A	Y	K	Q	A	V	T	P	A	D	A	I	G	D	I	A	V	I	T	E	L	T
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	D	D	S	V	K	L	V	F	S	E	R	D	E	Q	G	V	A	Q	L	T	W	F	L	G	G	R	T	A	S	L	S	Q	L	L	P	M	L	Q	S	M	G	V	V	V	L	E	E	R	P	F	S	V	T	R	P	D	G	L	P	V
Secondary structure
SS confidence
Disorder																								?		?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	W	I	Y	Q	F	K	I	S	P	H	P	T	I	P	L	A	P	T	V	A	E	R	A	A	T	A	H	R	F	A	E	A	V	T	A	I	W	H	G	R	V	E	I	D	R	F	N	E	L	V	M	R	A	G	L	T	W	Q	Q	V
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?																																					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	V	L	L	R	A	Y	A	K	Y	L	R	Q	A	G	F	P	Y	S	Q	S	Y	I	E	S	V	L	N	E	H	P	A	T	V	R	S	L	V	D	L	F	E	A	L	F	V	P	V	P	S	G	S	A	S	N	R	D	A	Q	A	A
Secondary structure
SS confidence
Disorder																																															?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	A	A	A	V	A	A	D	I	D	A	L	V	S	L	D	T	D	R	I	L	R	A	F	A	S	L	V	Q	A	T	L	R	T	N	Y	F	V	T	R	Q	G	S	A	R	C	R	D	V	L	A	L	K	L	N	A	Q	L	I	D	E
Secondary structure
SS confidence
Disorder								?					?																											?	?	?	?	?	?													?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	L	P	L	P	R	P	R	Y	E	I	F	V	Y	S	P	R	V	E	G	V	H	L	R	F	G	P	V	A	R	G	G	L	R	W	S	D	R	R	D	D	F	R	T	E	I	L	G	L	V	K	A	Q	A	V	K	N	A	V	I	V
Secondary structure
SS confidence
Disorder		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	P	V	G	A	K	G	G	F	V	V	K	R	P	P	L	P	T	G	D	P	A	A	D	R	D	A	T	R	A	E	G	V	A	C	Y	Q	L	F	I	S	G	L	L	D	V	T	D	N	V	D	H	A	T	A	S	V	N	P	P	P
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?	?																									?			?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	E	V	V	R	R	D	G	D	D	A	Y	L	V	V	A	A	D	K	G	T	A	T	F	S	D	I	A	N	D	V	A	K	S	Y	G	F	W	L	G	D	A	F	A	S	G	G	S	V	G	Y	D	H	K	A	M	G	I	T	A	R
Secondary structure
SS confidence
Disorder																																												?		?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	G	A	W	E	A	V	K	R	H	F	R	E	I	G	I	D	T	Q	T	Q	D	F	T	V	V	G	I	G	D	M	S	G	D	V	F	G	N	G	M	L	L	S	K	H	I	R	L	I	A	A	F	D	H	R	H	I	F	L	D	P
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	N	P	D	A	A	V	S	W	A	E	R	R	R	M	F	E	L	P	R	S	S	W	S	D	Y	D	R	S	L	I	S	E	G	G	G	V	Y	S	R	E	Q	K	A	I	P	L	S	A	Q	V	R	A	V	L	G	I	D	G	S	V
Secondary structure
SS confidence
Disorder																	?		?												?	?	?									?		?	?															?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	D	G	G	A	A	E	M	A	P	P	N	L	I	R	A	I	L	R	A	P	V	D	L	L	F	N	G	G	I	G	T	Y	I	K	A	E	S	E	S	D	A	D	V	G	D	R	A	N	D	P	V	R	V	N	A	N	Q	V	R	A
Secondary structure
SS confidence
Disorder	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	K	V	I	G	E	G	G	N	L	G	V	T	A	L	G	R	V	E	F	D	L	S	G	G	R	I	N	T	D	A	L	D	N	S	A	G	V	D	C	S	D	H	E	V	N	I	K	I	L	I	D	S	L	V	S	A	G	T	V	K
Secondary structure
SS confidence
Disorder																																																									?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	A	D	E	R	T	Q	L	L	E	S	M	T	D	E	V	A	Q	L	V	L	A	D	N	E	D	Q	N	D	L	M	G	T	S	R	A	N	A	A	S	L	L	P	V	H	A	M	Q	I	K	Y	L	V	A	E	R	G	V	N	R	E
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?															?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	L	E	A	L	P	S	E	K	E	I	A	R	R	S	E	A	G	I	G	L	T	S	P	E	L	A	T	L	M	A	H	V	K	L	G	L	K	E	E	V	L	A	T	E	L	P	D	Q	D	V	F	A	S	R	L	P	R	Y	F	P
Secondary structure
SS confidence
Disorder																?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	T	A	L	R	E	R	F	T	P	E	I	R	S	H	Q	L	R	R	E	I	V	T	T	M	L	I	N	D	L	V	D	T	A	G	I	T	Y	A	F	R	I	A	E	D	V	G	V	T	P	I	D	A	V	R	T	Y	V	A	T	D
Secondary structure
SS confidence
Disorder													?																																?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.	.	.	1400	.	.	.	.	.	.	.	.	.	1410	.	.	.	.	.	.	.	.	.	1420	.	.	.	.	.	.	.	.	.	1430	.	.	.	.	.	.	.	.	.	1440
Sequence	A	I	F	G	V	G	H	I	W	R	R	I	R	A	A	N	L	P	I	A	L	S	D	R	L	T	L	D	T	R	R	L	I	D	R	A	G	R	W	L	L	N	Y	R	P	Q	P	L	A	V	G	A	E	I	N	R	F	A	A	M
Secondary structure
SS confidence
Disorder															?		?																												?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1450	.	.	.	.	.	.	.	.	.	1460	.	.	.	.	.	.	.	.	.	1470	.	.	.	.	.	.	.	.	.	1480	.	.	.	.	.	.	.	.	.	1490	.	.	.	.	.	.	.	.	.	1500
Sequence	V	K	A	L	T	P	R	M	S	E	W	L	R	G	D	D	K	A	I	V	E	K	T	A	A	E	F	A	S	Q	G	V	P	E	D	L	A	Y	R	V	S	T	G	L	Y	R	Y	S	L	L	D	I	I	D	I	A	D	I	A	D
Secondary structure
SS confidence
Disorder								?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1510	.	.	.	.	.	.	.	.	.	1520	.	.	.	.	.	.	.	.	.	1530	.	.	.	.	.	.	.	.	.	1540	.	.	.	.	.	.	.	.	.	1550	.	.	.	.	.	.	.	.	.	1560
Sequence	I	D	A	A	E	V	A	D	T	Y	F	A	L	M	D	R	L	G	T	D	G	L	L	T	A	V	S	Q	L	P	R	H	D	R	W	H	S	L	A	R	L	A	I	R	D	D	I	Y	G	A	L	R	S	L	C	F	D	V	L	A
Secondary structure
SS confidence
Disorder																												?	?	?	?	?																												?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1570	.	.	.	.	.	.	.	.	.	1580	.	.	.	.	.	.	.	.	.	1590	.	.	.	.	.	.	.	.	.	1600	.	.	.	.	.	.	.	.	.	1610	.	.	.	.	.	.	.	.	.	1620
Sequence	V	G	E	P	G	E	S	S	E	Q	K	I	A	E	W	E	H	L	S	A	S	R	V	A	R	A	R	R	T	L	D	D	I	R	A	S	G	Q	K	D	L	A	T	L	S	V	A	A	R	Q	I	R	R	M	T	R	T	S	G	R
Secondary structure
SS confidence
Disorder	?		?	?														?																	?	?	?	?																		?	?	?	?	?
Disorder confidence

	.	.	.	.
Sequence	G	I	S	G
Secondary structure
SS confidence
Disorder	?	?	?	?
Disorder confidence