1

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10

.

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.

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20

.

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30

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40

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50

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.

.

.

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.

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.

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60

Sequence

V

A

L

R

R

R

H

E

P

D

G

W

P

F

S

Q

R

S

E

K

P

N

A

V

R

H

A

V

R

C

S

A

V

S

A

A

A

S

T

A

N

G

T

P

V

N

W

V

S

G

R

V

T

R

A

M

G

V

H

R

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

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.

.

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70

.

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80

.

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.

90

.

.

.

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.

.

.

.

.

100

.

.

.

.

.

.

.

Sequence

Q

T

R

G

G

V

A

S

V

H

A

D

S

L

R

G

A

V

L

V

H

G

Q

L

R

N

S

I

P

I

S

A

N

V

P

A

S

G

A

N

T

K

S

S

I

A

H

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 52%) Alpha helix ( 20%) Beta strand ( 28%)

Rank Aligned region

PDB 1pyv chain A Region: 75 - 102 Aligned: 28 Modelled: 28 Confidence: 21.7% Identity: 46% PDB header:hydrolase Chain: A: PDB Molecule:atp synthase beta chain, mitochondrial precursor; PDBTitle: nmr solution structure of the mitochondrial f1b presequence2 peptide from nicotiana plumbaginifolia Phyre2 PDB 5xzs chain A Region: 6 - 16 Aligned: 11 Modelled: 11 Confidence: 16.1% Identity: 45% PDB header:transcription Chain: A: PDB Molecule:histone acetyltransferase p300; PDBTitle: cryo-em structure of p300 Phyre2 PDB 2vld chain A Region: 44 - 75 Aligned: 19 Modelled: 30 Confidence: 13.0% Identity: 37% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease nucs; PDBTitle: crystal structure of a repair endonuclease from pyrococcus abyssi Phyre2 PDB 5u7g chain B Region: 6 - 16 Aligned: 11 Modelled: 11 Confidence: 12.2% Identity: 45% PDB header:transferase Chain: B: PDB Molecule:creb-binding protein; PDBTitle: crystal structure of the catalytic core of cbp Phyre2 PDB 4bhw chain B Region: 6 - 16 Aligned: 11 Modelled: 11 Confidence: 11.2% Identity: 45% PDB header:transferase Chain: B: PDB Molecule:histone acetyltransferase p300; PDBTitle: structural basis for autoinhibition of the acetyltransferase activity2 of p300 Phyre2 PDB 2pu9 chain B domain 1 Region: 51 - 95 Aligned: 45 Modelled: 45 Confidence: 11.0% Identity: 27% Fold: SH3-like barrel Superfamily: Electron transport accessory proteins Family: Ferredoxin thioredoxin reductase (FTR), alpha (variable) chain Phyre2 PDB 3u5r chain G Region: 22 - 50 Aligned: 29 Modelled: 29 Confidence: 9.4% Identity: 21% PDB header:structural genomics, unknown function Chain: G: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a hypothetical protein smc02350 from2 sinorhizobium meliloti 1021 Phyre2 PDB 5cfd chain D Region: 83 - 93 Aligned: 11 Modelled: 11 Confidence: 5.6% Identity: 64% PDB header:virus Chain: D: PDB Molecule:vp4; PDBTitle: crystal structure of dtt treated human cardiovirus safv-3 Phyre2 PDB 5cfc chain D Region: 83 - 93 Aligned: 11 Modelled: 11 Confidence: 5.6% Identity: 64% PDB header:virus Chain: D: PDB Molecule:vp4; PDBTitle: crystal structure of human cardiovirus safv-3 Phyre2 1 c1pyvA_ 2 c5xzsA_ 3 c2vldA_ 4 c5u7gB_ 5 c4bhwB_ 6 d2pu9b1 7 c3u5rG_ 8 c5cfdD_ 9 c5cfcD_