1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	N	P	G	S	R	A	G	T	L	L	H	F	R	V	V	A	W	A	M	W	D	C	G	S	T	G	L	N	A	I	V	T	T	F	V	F	S	V	Y	L	T	S	A	V	G	Q	G	L	P	G	G	T	S	P	A	S	W	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?																																		?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	R	A	G	A	V	A	G	L	T	I	G	V	L	A	P	V	V	G	V	W	V	E	S	P	H	R	R	R	V	A	L	S	V	L	T	G	T	A	V	A	L	T	C	A	M	F	L	I	R	D	D	P	R	Y	L	W	A	G	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	L	L	A	A	T	A	A	S	S	D	L	S	S	V	P	Y	N	A	M	L	R	Q	L	S	T	P	S	T	A	G	R	I	S	G	F	G	W	A	S	G	Y	V	G	S	V	A	L	L	L	V	I	Y	L	G	F	M	S	G	S
Secondary structure
SS confidence
Disorder																																																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	S	Q	R	G	L	L	Q	L	P	V	A	N	G	L	N	V	R	M	A	M	L	V	A	A	A	W	L	A	L	L	G	L	P	L	L	L	V	A	H	R	L	P	D	S	G	A	A	S	H	P	S	T	G	L	L	G	G	Y	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?								?																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	L	W	T	E	I	S	A	E	W	R	R	D	R	N	L	V	Y	F	L	V	A	S	A	I	F	R	D	G	L	A	A	I	F	A	F	G	A	V	L	G	V	N	A	Y	G	L	T	Q	A	D	V	L	I	F	G	A	A	A	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	V	A	A	V	G	A	V	L	G	G	F	V	D	H	R	I	G	S	K	P	V	I	V	G	S	L	A	A	I	I	A	A	A	L	T	L	L	T	L	S	G	P	T	A	F	W	A	C	G	L	L	L	C	V	F	I	G	P	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		Q	S	S	A	R	A	L	L	L	H	M	A	Q	H	G	K	E	G	V	A	F	G	L	Y	T	M	T	G	R	A	V	S	F	L	G	P	W	L	F	S	V	F	V	D	V	F	H	T	V	R	A	G	L	G	G	V	C	L	V	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.
Sequence		T	T	G	L	L	L	M	L	R	V	Q	V	S	R	H	G	G	A	L	T	T	A	Q	S	S
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 79%) Beta strand ( 0%) TM helix ( 59%) (View membrane topology prediction)

Rank Aligned region

PDB 1pw4 chain A Region: 2 - 443 Aligned: 414 Modelled: 424 Confidence: 100.0% Identity: 13% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 3wdo chain A Region: 6 - 445 Aligned: 401 Modelled: 409 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 4j05 chain A Region: 12 - 443 Aligned: 413 Modelled: 415 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 1pv7 chain A Region: 11 - 445 Aligned: 411 Modelled: 419 Confidence: 100.0% Identity: 10% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: LacY-like proton/sugar symporter Phyre2 PDB 1pv7 chain B Region: 11 - 445 Aligned: 411 Modelled: 419 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: B: PDB Molecule:lactose permease; PDBTitle: crystal structure of lactose permease with tdg Phyre2 PDB 6e9o chain A Region: 7 - 435 Aligned: 393 Modelled: 407 Confidence: 100.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 4cl5 chain B Region: 3 - 439 Aligned: 429 Modelled: 436 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 6g9x chain B Region: 14 - 436 Aligned: 368 Modelled: 378 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 5c65 chain A Region: 10 - 443 Aligned: 430 Modelled: 434 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: structure of the human glucose transporter glut3 / slc2a3 Phyre2 PDB 6h7d chain A Region: 10 - 443 Aligned: 427 Modelled: 429 Confidence: 100.0% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 PDB 4lds chain B Region: 16 - 434 Aligned: 406 Modelled: 414 Confidence: 100.0% Identity: 12% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 5ayn chain A Region: 15 - 432 Aligned: 398 Modelled: 413 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 39 (iron-regulated transporter); PDBTitle: crystal structure of a bacterial homologue of iron transporter2 ferroportin in outward-facing state Phyre2 PDB 4ybq chain B Region: 6 - 443 Aligned: 428 Modelled: 438 Confidence: 100.0% Identity: 10% PDB header:transport protein/immune system Chain: B: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: rat glut5 with fv in the outward-open form Phyre2 PDB 4iu8 chain A Region: 2 - 430 Aligned: 412 Modelled: 398 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter (selenomethionine2 derivative) Phyre2 PDB 4w6v chain A Region: 2 - 436 Aligned: 430 Modelled: 433 Confidence: 99.9% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:di-/tripeptide transporter; PDBTitle: crystal structure of a peptide transporter from yersinia2 enterocolitica at 3 a resolution Phyre2 PDB 4zp0 chain A Region: 6 - 431 Aligned: 387 Modelled: 397 Confidence: 99.9% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 3o7p chain A Region: 15 - 433 Aligned: 407 Modelled: 419 Confidence: 99.9% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 5aym chain A Region: 15 - 432 Aligned: 397 Modelled: 413 Confidence: 99.9% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 39 (iron-regulated transporter); PDBTitle: crystal structure of a bacterial homologue of iron transporter2 ferroportin in outward-facing state with soaked iron Phyre2 PDB 4gbz chain A Region: 10 - 444 Aligned: 435 Modelled: 435 Confidence: 99.9% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:d-xylose-proton symporter; PDBTitle: the structure of the mfs (major facilitator superfamily) proton:xylose2 symporter xyle bound to d-glucose Phyre2 PDB 6ei3 chain A Region: 15 - 443 Aligned: 425 Modelled: 429 Confidence: 99.9% Identity: 9% PDB header:membrane protein Chain: A: PDB Molecule:proton-dependent oligopeptide transporter family protein; PDBTitle: crystal structure of auto inhibited pot family peptide transporter Phyre2 1 d1pw4a_ 2 c3wdoA_ 3 c4j05A_ 4 d1pv7a_ 5 c1pv7B_ 6 c6e9oA_ 7 c4cl5B_ 8 c6g9xB_ 9 c5c65A_ 10 c6h7dA_ 11 c4ldsB_ 12 c5aynA_ 13 c4ybqB_ 14 c4iu8A_ 15 c4w6vA_ 16 c4zp0A_ 17 c3o7pA_ 18 c5aymA_ 19 c4gbzA_ 20 c6ei3A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41