1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	Q	D	E	L	V	W	I	D	C	E	M	T	G	L	D	L	G	S	D	K	L	I	E	I	A	A	L	V	T	D	A	D	L	N	I	L	G	D	G	V	D	V	V	M	H	A	D	D	A	A	L	S	G	M	I	D	V	V	A
Secondary structure
SS confidence
Disorder		?	?	?																																															?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	M	H	S	R	S	G	L	I	D	E	V	K	A	S	T	V	D	L	A	T	A	E	A	M	V	L	D	Y	I	N	E	H	V	K	Q	P	K	T	A	P	L	A	G	N	S	I	A	T	D	R	A	F	I	A	R	D	M	P	T
Secondary structure
SS confidence
Disorder															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	D	S	F	L	H	Y	R	M	I	D	V	S	S	I	K	E	L	C	R	R	W	Y	P	R	I	Y	F	G	Q	P	P	K	G	L	T	H	R	A	L	A	D	I	H	E	S	I	R	E	L	R	F	Y	R	R	T	A	F	V	P
Secondary structure
SS confidence
Disorder																														?			?	?	?	?																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.
Sequence		Q	P	G	P	S	T	S	E	I	A	A	V	V	A	E	L	S	D	G	A	G	A	Q	E	E	T	D	S	A	E	A	P	Q	S	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 45%) Beta strand ( 13%)

Rank Aligned region

PDB 6n6j chain B Region: 1 - 178 Aligned: 177 Modelled: 178 Confidence: 100.0% Identity: 48% PDB header:rna binding protein/rna Chain: B: PDB Molecule:rna exonuclease 2 homolog,small fragment nuclease; PDBTitle: human rexo2 bound to paa Phyre2 PDB 6n6d chain A Region: 2 - 178 Aligned: 175 Modelled: 177 Confidence: 100.0% Identity: 43% PDB header:rna binding protein/rna Chain: A: PDB Molecule:oligoribonuclease; PDBTitle: vibrio cholerae oligoribonuclease bound to pag Phyre2 PDB 5cy4 chain C Region: 1 - 181 Aligned: 178 Modelled: 181 Confidence: 100.0% Identity: 42% PDB header:oxidoreductase Chain: C: PDB Molecule:oligoribonuclease; PDBTitle: crystal structure of an oligoribonuclease from acinetobacter baumannii Phyre2 PDB 6a4d chain A Region: 1 - 178 Aligned: 176 Modelled: 178 Confidence: 100.0% Identity: 41% PDB header:hydrolase Chain: A: PDB Molecule:oligoribonuclease; PDBTitle: pnp-tmp bound oligoribonuclease (orn) from colwellia psychrerythraea2 strain 34h Phyre2 PDB 3tr8 chain A Region: 2 - 178 Aligned: 175 Modelled: 177 Confidence: 100.0% Identity: 41% PDB header:hydrolase Chain: A: PDB Molecule:oligoribonuclease; PDBTitle: structure of an oligoribonuclease (orn) from coxiella burnetii Phyre2 PDB 1j9a chain A Region: 2 - 181 Aligned: 178 Modelled: 180 Confidence: 100.0% Identity: 42% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 2igi chain A domain 1 Region: 2 - 178 Aligned: 175 Modelled: 177 Confidence: 100.0% Identity: 46% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 2gbz chain A Region: 3 - 175 Aligned: 171 Modelled: 173 Confidence: 100.0% Identity: 45% PDB header:hydrolase Chain: A: PDB Molecule:oligoribonuclease; PDBTitle: the crystal structure of xc847 from xanthomonas campestris: a 3-52 oligoribonuclease of dnaq fold family with a novel opposingly-shifted3 helix Phyre2 PDB 5z9x chain A Region: 2 - 175 Aligned: 148 Modelled: 167 Confidence: 100.0% Identity: 19% PDB header:plant protein/rna Chain: A: PDB Molecule:small rna degrading nuclease 1; PDBTitle: arabidopsis small rna degrading nuclease 1 in complex with an rna2 substrate Phyre2 PDB 2qxf chain A domain 1 Region: 2 - 175 Aligned: 164 Modelled: 174 Confidence: 100.0% Identity: 16% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 1y97 chain A domain 1 Region: 2 - 178 Aligned: 169 Modelled: 177 Confidence: 100.0% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 4rg8 chain A Region: 5 - 176 Aligned: 161 Modelled: 172 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:exonuclease i; PDBTitle: structural and biochemical studies of a moderately thermophilic2 exonuclease i from methylocaldum szegediense Phyre2 PDB 3b6o chain A domain 1 Region: 3 - 178 Aligned: 167 Modelled: 176 Confidence: 100.0% Identity: 12% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 3u6f chain A Region: 3 - 178 Aligned: 166 Modelled: 176 Confidence: 99.9% Identity: 11% PDB header:hydrolase/dna Chain: A: PDB Molecule:three prime repair exonuclease 1; PDBTitle: mouse trex1 d200n mutant Phyre2 PDB 5fkv chain D Region: 4 - 175 Aligned: 157 Modelled: 172 Confidence: 99.9% Identity: 21% PDB header:transferase Chain: D: PDB Molecule:dna polymerase iii epsilon; PDBTitle: cryo-em structure of the e. coli replicative dna polymerase complex2 bound to dna (dna polymerase iii alpha, beta, epsilon, tau complex) Phyre2 PDB 1w0h chain A Region: 3 - 176 Aligned: 169 Modelled: 165 Confidence: 99.9% Identity: 14% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 2gui chain A domain 1 Region: 4 - 174 Aligned: 156 Modelled: 171 Confidence: 99.9% Identity: 23% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 2f96 chain A domain 1 Region: 5 - 177 Aligned: 168 Modelled: 173 Confidence: 99.9% Identity: 16% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 PDB 3cm6 chain A Region: 3 - 175 Aligned: 167 Modelled: 173 Confidence: 99.9% Identity: 14% PDB header:hydrolase, apoptosis Chain: A: PDB Molecule:cell death-related nuclease 4; PDBTitle: crystal structure of cell-death related nuclease 4 (crn-4)2 bound with er Phyre2 PDB 1wlj chain A Region: 4 - 175 Aligned: 150 Modelled: 172 Confidence: 99.9% Identity: 21% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: DnaQ-like 3'-5' exonuclease Phyre2 1 c6n6jB_ 2 c6n6dA_ 3 c5cy4C_ 4 c6a4dA_ 5 c3tr8A_ 6 d1j9aa_ 7 d2igia1 8 c2gbzA_ 9 c5z9xA_ 10 d2qxfa1 11 d1y97a1 12 c4rg8A_ 13 d3b6oa1 14 c3u6fA_ 15 c5fkvD_ 16 d1w0ha_ 17 d2guia1 18 d2f96a1 19 c3cm6A_ 20 d1wlja_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99