1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	Y	S	F	D	T	S	A	I	L	N	G	R	R	D	L	F	R	P	A	V	F	R	S	L	W	G	R	V	E	D	A	I	S	A	G	Q	I	R	S	V	D	E	V	Q	R	E	L	A	R	R	D	D	D	A	K	R	W	A
Secondary structure
SS confidence
Disorder		?					?																																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	G	Q	T	G	L	F	C	P	L	D	E	Q	I	Q	Q	A	A	R	H	I	L	R	L	H	P	N	M	V	R	Q	G	G	R	R	S	A	A	D	P	F	V	I	A	L	A	M	V	N	N	A	T	V	V	T	Q	E	T	A	S
Secondary structure
SS confidence
Disorder																																?	?		?	?																							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.
Sequence		G	N	I	E	K	P	R	I	P	D	V	C	D	A	L	G	V	P	W	L	T	L	M	G	Y	I	E	A	Q	G	W	T	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?																								?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 52%) Beta strand ( 12%)

Rank Aligned region

PDB 2h1c chain A domain 1 Region: 2 - 143 Aligned: 126 Modelled: 142 Confidence: 99.7% Identity: 16% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1v96 chain A domain 1 Region: 3 - 148 Aligned: 130 Modelled: 146 Confidence: 99.7% Identity: 12% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1y82 chain A domain 1 Region: 3 - 148 Aligned: 130 Modelled: 146 Confidence: 99.7% Identity: 11% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3zvk chain C Region: 1 - 130 Aligned: 125 Modelled: 130 Confidence: 99.7% Identity: 17% PDB header:antitoxin/toxin/dna Chain: C: PDB Molecule:toxin of toxin-antitoxin system; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 6nkl chain A Region: 1 - 130 Aligned: 125 Modelled: 130 Confidence: 99.6% Identity: 15% PDB header:antitoxin Chain: A: PDB Molecule:ribonuclease vapc; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 3h87 chain B Region: 3 - 121 Aligned: 110 Modelled: 119 Confidence: 99.6% Identity: 14% PDB header:toxin/antitoxin Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 4chg chain C Region: 3 - 143 Aligned: 129 Modelled: 133 Confidence: 99.6% Identity: 17% PDB header:toxin/antitoxin Chain: C: PDB Molecule:probable ribonuclease vapc15; PDBTitle: crystal structure of vapbc15 complex from mycobacterium tuberculosis Phyre2 PDB 3tnd chain C Region: 1 - 130 Aligned: 123 Modelled: 130 Confidence: 99.6% Identity: 15% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 5sv2 chain A Region: 3 - 142 Aligned: 124 Modelled: 140 Confidence: 99.6% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease vapc21; PDBTitle: toxin vapc21 from mycobacterium tuberculosis Phyre2 PDB 5l6m chain C Region: 3 - 143 Aligned: 120 Modelled: 141 Confidence: 99.5% Identity: 24% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 3dbo chain B Region: 3 - 123 Aligned: 104 Modelled: 105 Confidence: 99.5% Identity: 19% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 PDB 3ix7 chain A Region: 3 - 152 Aligned: 125 Modelled: 139 Confidence: 99.4% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ttha0540; PDBTitle: crystal structure of a domain of functionally unknown protein from2 thermus thermophilus hb8 Phyre2 PDB 6a7v chain G Region: 3 - 141 Aligned: 128 Modelled: 139 Confidence: 99.3% Identity: 18% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 4xgr chain G Region: 3 - 140 Aligned: 118 Modelled: 126 Confidence: 99.1% Identity: 11% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 5yww chain A Region: 3 - 140 Aligned: 113 Modelled: 138 Confidence: 98.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:nucleotide binding protein pinc; PDBTitle: archael ruvb-like holiday junction helicase Phyre2 PDB 5f4h chain F Region: 1 - 140 Aligned: 115 Modelled: 129 Confidence: 98.8% Identity: 18% PDB header:hydrolase Chain: F: PDB Molecule:nucleotide binding protein pinc; PDBTitle: archael ruvb-like holiday junction helicase Phyre2 PDB 3i8o chain A Region: 2 - 142 Aligned: 122 Modelled: 141 Confidence: 98.8% Identity: 14% PDB header:rna binding protein Chain: A: PDB Molecule:kh domain-containing protein mj1533; PDBTitle: a domain of a functionally unknown protein from methanocaldococcus2 jannaschii dsm 2661. Phyre2 PDB 2fe1 chain A Region: 1 - 119 Aligned: 113 Modelled: 119 Confidence: 98.7% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein pae0151; PDBTitle: crystal structure of pae0151 from pyrobaculum aerophilum Phyre2 PDB 2fe1 chain A domain 1 Region: 1 - 119 Aligned: 113 Modelled: 119 Confidence: 98.7% Identity: 15% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 2lcq chain A Region: 3 - 150 Aligned: 117 Modelled: 127 Confidence: 98.6% Identity: 18% PDB header:metal binding protein Chain: A: PDB Molecule:putative toxin vapc6; PDBTitle: solution structure of the endonuclease nob1 from p.horikoshii Phyre2 1 d2h1ca1 2 d1v96a1 3 d1y82a1 4 c3zvkC_ 5 c6nklA_ 6 c3h87B_ 7 c4chgC_ 8 c3tndC_ 9 c5sv2A_ 10 c5l6mC_ 11 c3dboB_ 12 c3ix7A_ 13 c6a7vG_ 14 c4xgrG_ 15 c5ywwA_ 16 c5f4hF_ 17 c3i8oA_ 18 c2fe1A_ 19 d2fe1a1 20 c2lcqA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99