1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	K	V	G	I	A	A	Q	A	G	R	T	R	V	R	R	A	W	L	T	A	L	M	M	T	A	V	M	I	G	A	V	A	C	G	S	G	R	G	P	A	P	I	K	V	I	A	D	K	G	T	P	F	A	D	L	L	V	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	L	T	A	S	V	T	D	G	A	V	G	V	T	V	D	A	P	V	S	V	T	A	A	D	G	V	L	A	A	V	T	M	V	N	D	N	G	R	P	V	A	G	R	L	S	P	D	G	L	R	W	S	T	T	E	Q	L	G	Y
Secondary structure
SS confidence
Disorder								?		?	?	?	?			?											?	?									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	R	R	Y	T	L	N	A	T	A	L	G	L	G	G	A	A	T	R	Q	L	T	F	Q	T	S	S	P	A	H	L	T	M	P	Y	V	M	P	G	D	G	E	V	V	G	V	G	E	P	V	A	I	R	F	D	E	N	I	A	D
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?				?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	G	A	A	E	K	A	I	K	I	T	T	N	P	P	V	E	G	A	F	Y	W	L	N	N	R	E	V	R	W	R	P	E	H	F	W	K	P	G	T	A	V	D	V	A	V	N	T	Y	G	V	D	L	G	E	G	M	F	G	E
Secondary structure
SS confidence
Disorder		?		?		?						?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	N	V	Q	T	H	F	T	I	G	D	E	V	I	A	T	A	D	D	N	T	K	I	L	T	V	R	V	N	G	E	V	V	K	S	M	P	T	S	M	G	K	D	S	T	P	T	A	N	G	I	Y	I	V	G	S	R	Y	K	H
Secondary structure
SS confidence
Disorder																																												?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	I	M	D	S	S	T	Y	G	V	P	V	N	S	P	N	G	Y	R	T	D	V	D	W	A	T	Q	I	S	Y	S	G	V	F	V	H	S	A	P	W	S	V	G	A	Q	G	H	T	N	T	S	H	G	C	L	N	V	S	P	S
Secondary structure
SS confidence
Disorder															?																												?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.
Sequence		N	A	Q	W	F	Y	D	H	V	K	R	G	D	I	V	E	V	V	N	T	V	G	G	T	L	P	G	I	D	G	L	G	D	W	N	I	P	W	D	Q	W	R	A	G	N	A	K	A
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?															?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 26%) Alpha helix ( 10%) Beta strand ( 39%)

Rank Aligned region

PDB 3vyn chain B Region: 59 - 406 Aligned: 348 Modelled: 348 Confidence: 100.0% Identity: 100% PDB header:transferase Chain: B: PDB Molecule:probable conserved lipoprotein lpps; PDBTitle: crystal structure of mycobacterium tuberculosis l,d-transpeptidase2 ldtmt2 n55 truncation mutant (resideus 55-408) Phyre2 PDB 4z7a chain A Region: 52 - 408 Aligned: 344 Modelled: 357 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:mycobacterium tuberculosis (3,3)l,d-transpeptidase type 5; PDBTitle: structural and biochemical characterization of a non-functionally2 redundant m. tuberculosis (3,3) l,d-transpeptidase, ldtmt5. Phyre2 PDB 3u1q chain B Region: 150 - 407 Aligned: 258 Modelled: 258 Confidence: 100.0% Identity: 100% PDB header:peptidoglycan binding protein Chain: B: PDB Molecule:mycobacteria tuberculosis ld-transpeptidase type 2; PDBTitle: crystal structure of m. tuberculosis ld-transpeptidase type 2 with 2-2 mercaptoethanol Phyre2 PDB 4xvo chain B Region: 149 - 379 Aligned: 217 Modelled: 217 Confidence: 100.0% Identity: 41% PDB header:transferase Chain: B: PDB Molecule:l,d-transpeptidase; PDBTitle: l,d-transpeptidase from mycobacterium smegmatis Phyre2 PDB 4jmx chain A Region: 149 - 378 Aligned: 216 Modelled: 216 Confidence: 100.0% Identity: 44% PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:probable l,d-transpeptidase ldta; PDBTitle: structure of ld transpeptidase ldtmt1 in complex with imipenem Phyre2 PDB 4k73 chain A Region: 151 - 378 Aligned: 204 Modelled: 214 Confidence: 100.0% Identity: 42% PDB header:transferase Chain: A: PDB Molecule:l,d-transpeptidase; PDBTitle: x-ray crystal structure of an l,d-transpeptidase from mycobacterium2 tuberculosis h37rv Phyre2 PDB 4hu2 chain A Region: 59 - 250 Aligned: 192 Modelled: 192 Confidence: 100.0% Identity: 100% PDB header:unknown function Chain: A: PDB Molecule:probable conserved lipoprotein lpps; PDBTitle: crystal structure of ldtmt2, a l,d-transpeptidase from mycobacterium2 tuberculosis: domain a and b Phyre2 PDB 2hkl chain B Region: 170 - 377 Aligned: 200 Modelled: 208 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: B: PDB Molecule:l,d-transpeptidase; PDBTitle: crystal structure of enterococcus faecium l,d-2 transpeptidase c442s mutant Phyre2 PDB 5bmq chain A Region: 248 - 384 Aligned: 122 Modelled: 137 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:erfk/ybis/ycfs/ynhg family protein; PDBTitle: crystal structure of l,d-transpeptidase (yku) from stackebrandtia2 nassauensis Phyre2 PDB 1zat chain A domain 1 Region: 249 - 377 Aligned: 121 Modelled: 129 Confidence: 100.0% Identity: 28% Fold: L,D-transpeptidase catalytic domain-like Superfamily: L,D-transpeptidase catalytic domain-like Family: L,D-transpeptidase catalytic domain-like Phyre2 PDB 1y7m chain A domain 1 Region: 251 - 378 Aligned: 110 Modelled: 112 Confidence: 100.0% Identity: 22% Fold: L,D-transpeptidase catalytic domain-like Superfamily: L,D-transpeptidase catalytic domain-like Family: L,D-transpeptidase catalytic domain-like Phyre2 PDB 1y7m chain B Region: 251 - 378 Aligned: 110 Modelled: 112 Confidence: 100.0% Identity: 22% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein bsu14040; PDBTitle: crystal structure of the b. subtilis ykud protein at 2 a2 resolution Phyre2 PDB 4lzh chain A Region: 250 - 390 Aligned: 138 Modelled: 141 Confidence: 99.9% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:l,d-transpeptidase; PDBTitle: l,d-transpeptidase from klebsiella pneumoniae Phyre2 PDB 4lpq chain A Region: 251 - 377 Aligned: 121 Modelled: 127 Confidence: 99.9% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:erfk/ybis/ycfs/ynhg family protein; PDBTitle: crystal structure of the l,d-transpeptidase (residues 123-326) from2 xylanimonas cellulosilytica dsm 15894 Phyre2 PDB 4xxt chain A Region: 252 - 377 Aligned: 108 Modelled: 109 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:fusion of predicted zn-dependent amidase/peptidase (cell PDBTitle: crystal structure of fused zn-dependent2 amidase/peptidase/peptodoglycan-binding domain-containing protein3 from clostridium acetobutylicum atcc 824 Phyre2 PDB 4y4v chain B Region: 240 - 389 Aligned: 144 Modelled: 150 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:conserved hypothetical secreted protein; PDBTitle: structure of helicobacter pylori csd6 in the d-ala-bound state Phyre2 PDB 6ntw chain A Region: 255 - 367 Aligned: 112 Modelled: 113 Confidence: 99.3% Identity: 16% PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:probable l,d-transpeptidase ycbb; PDBTitle: crystal structure of e. coli ycbb Phyre2 PDB 5icu chain A Region: 59 - 151 Aligned: 93 Modelled: 93 Confidence: 97.4% Identity: 12% PDB header:chaperone Chain: A: PDB Molecule:copc; PDBTitle: the crystal structure of copc from methylosinus trichosporium ob3b Phyre2 PDB 6nfq chain C Region: 59 - 144 Aligned: 84 Modelled: 86 Confidence: 97.2% Identity: 13% PDB header:metal binding protein Chain: C: PDB Molecule:copc; PDBTitle: copc from pseudomonas fluorescens Phyre2 PDB 2c9q chain A domain 1 Region: 59 - 144 Aligned: 84 Modelled: 86 Confidence: 97.0% Identity: 13% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Copper resistance protein C (CopC, PcoC) Phyre2 1 c3vynB_ 2 c4z7aA_ 3 c3u1qB_ 4 c4xvoB_ 5 c4jmxA_ 6 c4k73A_ 7 c4hu2A_ 8 c2hklB_ 9 c5bmqA_ 10 d1zata1 11 d1y7ma1 12 c1y7mB_ 13 c4lzhA_ 14 c4lpqA_ 15 c4xxtA_ 16 c4y4vB_ 17 c6ntwA_ 18 c5icuA_ 19 c6nfqC_ 20 d2c9qa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224