1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	H	L	A	H	R	V	A	S	S	R	D	T	P	S	S	S	A	T	P	N	A	V	S	G	S	A	S	N	A	A	D	R	P	C	L	V	R	P	P	T	A	P	P	W	A	H	G	P	R	L	R	R	D	P	T	G	G	G	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?										?		?	?	?						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	P	S	I	V	L	S	R	S	T	D	R	S	K	D	G	H	R	I	V	P	A	G	A	R	K	S	G	V	R	A	S	T	G	R	L	P	S	T	R	K	T	T	R	S	P	D	C	R	P	S	A	S	R	T	A	F	G	T	V
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	C	P	F	D	V	T	M	G	S	S	E	C	L	L	H	R	C	R	T	P	P	V	P	S	H	S	V	E	L	L	V	A	A	N	P	A	E	D	S	R	L	P	Y	L	I	R	L	P	V	G	A	G	L	V	F	A	T	S	D
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	W	P	R	T	K	A	L	Y	C	H	R	L	D	I	A	D	W	P	A	D	P	V	V	V	D	R	V	E	L	R	S	C	S	R	R	G	A	A	I	D	V	V	A	A	R	A	R	E	N	R	S	Q	L	V	H	T	M	A	R
Secondary structure
SS confidence
Disorder		?														?	?				?						?				?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	R	Q	V	V	F	W	Q	S	P	K	T	R	K	Q	S	R	P	G	V	R	T	P	T	A	R	A	A	G	I	P	E	L	H	I	V	V	D	A	H	E	R	Y	P	Y	T	F	A	D	K	P	A	K	T	T	R	E	A	L	P
Secondary structure
SS confidence
Disorder				?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		C	G	D	Y	G	L	K	V	A	G	Q	L	V	A	A	V	E	R	K	A	L	A	D	L	T	S	G	V	L	N	G	N	L	K	Y	Q	L	T	E	L	A	A	L	P	R	A	A	V	V	V	E	D	R	Y	S	E	I	F	A	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	F	A	R	P	T	A	I	A	D	G	L	A	E	L	Q	I	G	F	P	N	V	P	I	V	F	C	Q	T	R	K	L	A	Q	E	Y	T	Y	R	Y	L	A	A	A	L	T	W	F	V	D	D	A	D	A	T	T	V	F	E	P
Secondary structure
SS confidence
Disorder					?																																														?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.
Sequence		A	A	A	E	P	E	P	S	S	A	E	L	R	A	W	A	K	S	V	G	L	P	V	S	D	R	G	R	L	R	P	Q	I	L	Q	A	W	R	A	A	H	P	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?											?			?	?	?	?	?		?	?										?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 32%) Alpha helix ( 21%) Beta strand ( 28%)

Rank Aligned region

PDB 1j23 chain A Region: 273 - 402 Aligned: 122 Modelled: 130 Confidence: 99.9% Identity: 29% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: XPF/Rad1/Mus81 nuclease Phyre2 PDB 2bgw chain A domain 2 Region: 273 - 403 Aligned: 124 Modelled: 131 Confidence: 99.9% Identity: 20% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: XPF/Rad1/Mus81 nuclease Phyre2 PDB 2bhn chain D Region: 273 - 445 Aligned: 146 Modelled: 153 Confidence: 99.8% Identity: 20% PDB header:hydrolase Chain: D: PDB Molecule:xpf endonuclease; PDBTitle: xpf from aeropyrum pernix Phyre2 PDB 4bxo chain A Region: 275 - 428 Aligned: 120 Modelled: 134 Confidence: 99.8% Identity: 24% PDB header:hydrolase/dna Chain: A: PDB Molecule:fanconi anemia group m protein; PDBTitle: architecture and dna recognition elements of the fanconi anemia fancm-2 faap24 complex Phyre2 PDB 2ziu chain A Region: 267 - 404 Aligned: 136 Modelled: 138 Confidence: 99.8% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:mus81 protein; PDBTitle: crystal structure of the mus81-eme1 complex Phyre2 PDB 2zix chain A Region: 263 - 427 Aligned: 137 Modelled: 145 Confidence: 99.8% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:crossover junction endonuclease mus81; PDBTitle: crystal structure of the mus81-eme1 complex Phyre2 PDB 4bxo chain B Region: 270 - 430 Aligned: 126 Modelled: 133 Confidence: 99.8% Identity: 15% PDB header:hydrolase/dna Chain: B: PDB Molecule:fanconi anemia-associated protein of 24 kda; PDBTitle: architecture and dna recognition elements of the fanconi anemia fancm-2 faap24 complex Phyre2 PDB 2kng chain A Region: 427 - 462 Aligned: 36 Modelled: 36 Confidence: 98.1% Identity: 39% PDB header:dna binding protein Chain: A: PDB Molecule:protein lsr2; PDBTitle: solution structure of c-domain of lsr2 Phyre2 PDB 1wp9 chain A domain 2 Region: 213 - 250 Aligned: 33 Modelled: 38 Confidence: 96.5% Identity: 21% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Tandem AAA-ATPase domain Phyre2 PDB 1wp9 chain D Region: 213 - 250 Aligned: 33 Modelled: 38 Confidence: 95.8% Identity: 21% PDB header:hydrolase Chain: D: PDB Molecule:atp-dependent rna helicase, putative; PDBTitle: crystal structure of pyrococcus furiosus hef helicase domain Phyre2 PDB 2zix chain B Region: 270 - 417 Aligned: 117 Modelled: 128 Confidence: 94.9% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:crossover junction endonuclease eme1; PDBTitle: crystal structure of the mus81-eme1 complex Phyre2 PDB 1a1v chain A Region: 149 - 245 Aligned: 69 Modelled: 73 Confidence: 66.0% Identity: 20% PDB header:hydrolase/dna Chain: A: PDB Molecule:protein (ns3 protein); PDBTitle: hepatitis c virus ns3 helicase domain complexed with single2 stranded sdna Phyre2 PDB 8ohm chain A domain 2 Region: 144 - 240 Aligned: 78 Modelled: 84 Confidence: 53.6% Identity: 19% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: RNA helicase Phyre2 PDB 1zak chain A domain 2 Region: 183 - 211 Aligned: 26 Modelled: 29 Confidence: 48.0% Identity: 23% Fold: Rubredoxin-like Superfamily: Microbial and mitochondrial ADK, insert "zinc finger" domain Family: Microbial and mitochondrial ADK, insert "zinc finger" domain Phyre2 PDB 5vfk chain A Region: 283 - 350 Aligned: 62 Modelled: 63 Confidence: 45.0% Identity: 18% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of an archaeal duf61 family protein sso0941 Phyre2 PDB 4gl2 chain A Region: 209 - 260 Aligned: 46 Modelled: 52 Confidence: 38.4% Identity: 28% PDB header:rna binding protein/rna Chain: A: PDB Molecule:interferon-induced helicase c domain-containing protein 1; PDBTitle: structural basis for dsrna duplex backbone recognition by mda5 Phyre2 PDB 1a1v chain A domain 2 Region: 149 - 245 Aligned: 73 Modelled: 78 Confidence: 37.4% Identity: 18% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: RNA helicase Phyre2 PDB 5n8z chain A Region: 182 - 244 Aligned: 56 Modelled: 63 Confidence: 34.8% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:cg9323, isoform a; PDBTitle: crystal structure of drosophila dhx36 helicase in complex with2 ctctccctt Phyre2 PDB 2f55 chain C Region: 213 - 240 Aligned: 23 Modelled: 28 Confidence: 33.7% Identity: 30% PDB header:hydrolase/dna Chain: C: PDB Molecule:polyprotein; PDBTitle: two hepatitis c virus ns3 helicase domains complexed with the same2 strand of dna Phyre2 PDB 2hg7 chain A domain 1 Region: 392 - 435 Aligned: 44 Modelled: 44 Confidence: 32.9% Identity: 27% Fold: gpW/XkdW-like Superfamily: XkdW-like Family: XkdW-like Phyre2 1 d1j23a_ 2 d2bgwa2 3 c2bhnD_ 4 c4bxoA_ 5 c2ziuA_ 6 c2zixA_ 7 c4bxoB_ 8 c2kngA_ 9 d1wp9a2 10 c1wp9D_ 11 c2zixB_ 12 c1a1vA_ 13 d8ohma2 14 d1zaka2 15 c5vfkA_ 16 c4gl2A_ 17 d1a1va2 18 c5n8zA_ 19 c2f55C_ 20 d2hg7a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99