1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	R	W	I	T	A	G	E	S	H	G	R	A	L	V	A	V	V	E	G	M	V	A	G	V	H	V	T	S	A	D	I	A	D	Q	L	A	R	R	R	L	G	Y	G	R	G	A	R	M	T	F	E	R	D	A	V	T	V	L
Secondary structure
SS confidence
Disorder		?	?			?	?																																		?	?		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	G	I	R	H	G	S	T	L	G	G	P	I	A	I	E	I	G	N	T	E	W	P	K	W	E	T	V	M	A	A	D	P	V	D	P	A	E	L	A	D	V	A	R	N	A	P	L	T	R	P	R	P	G	H	A	D	Y	A	G
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?	?	?	?	?	?	?					?	?	?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	L	K	Y	G	F	D	D	A	R	P	V	L	E	R	A	S	A	R	E	T	A	A	R	V	A	A	G	T	V	A	R	A	F	L	R	Q	A	L	G	V	E	V	L	S	H	V	I	S	I	G	A	S	A	P	Y	E	G	P	P
Secondary structure
SS confidence
Disorder												?	?		?																																								?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	R	A	E	D	L	P	A	I	D	A	S	P	V	R	A	Y	D	K	A	A	E	A	D	M	I	A	Q	I	E	A	A	K	K	D	G	D	T	L	G	G	V	V	E	A	V	A	L	G	L	P	V	G	L	G	S	F	T	S	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	H	R	L	D	S	Q	L	A	A	A	V	M	G	I	Q	A	I	K	G	V	E	I	G	D	G	F	Q	T	A	R	R	R	G	S	R	A	H	D	E	M	Y	P	G	P	D	G	V	V	R	S	T	N	R	A	G	G	L	E	G
Secondary structure
SS confidence
Disorder																																															?					?			?				?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	M	T	N	G	Q	P	L	R	V	R	A	A	M	K	P	I	S	T	V	P	R	A	L	A	T	V	D	L	A	T	G	D	E	A	V	A	I	H	Q	R	S	D	V	C	A	V	P	A	A	G	V	V	V	E	T	M	V	A	L
Secondary structure
SS confidence
Disorder		?																		?	?	?	?	?	?	?			?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.
Sequence		V	L	A	R	A	A	L	E	K	F	G	G	D	S	L	A	E	T	Q	R	N	I	A	A	Y	Q	R	S	V	A	D	R	E	A	P	A	A	R	V	S	G
Secondary structure
SS confidence
Disorder															?																?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 33%) Beta strand ( 19%)

Rank Aligned region

PDB 1ztb chain A Region: 1 - 392 Aligned: 388 Modelled: 392 Confidence: 100.0% Identity: 99% PDB header:ligase Chain: A: PDB Molecule:chorismate synthase; PDBTitle: crystal structure of chorismate synthase from mycobacterium2 tuberculosis Phyre2 PDB 1qxo chain A Region: 2 - 391 Aligned: 385 Modelled: 389 Confidence: 100.0% Identity: 44% Fold: Chorismate synthase, AroC Superfamily: Chorismate synthase, AroC Family: Chorismate synthase, AroC Phyre2 PDB 1um0 chain A Region: 1 - 383 Aligned: 351 Modelled: 362 Confidence: 100.0% Identity: 34% Fold: Chorismate synthase, AroC Superfamily: Chorismate synthase, AroC Family: Chorismate synthase, AroC Phyre2 PDB 1q1l chain A Region: 1 - 391 Aligned: 323 Modelled: 330 Confidence: 100.0% Identity: 47% Fold: Chorismate synthase, AroC Superfamily: Chorismate synthase, AroC Family: Chorismate synthase, AroC Phyre2 PDB 4lj2 chain A Region: 1 - 378 Aligned: 307 Modelled: 320 Confidence: 100.0% Identity: 37% PDB header:lyase Chain: A: PDB Molecule:chorismate synthase; PDBTitle: crystal structure of chorismate synthase from acinetobacter baumannii2 at 3.15a resolution Phyre2 PDB 1sq1 chain A Region: 1 - 382 Aligned: 281 Modelled: 303 Confidence: 100.0% Identity: 37% Fold: Chorismate synthase, AroC Superfamily: Chorismate synthase, AroC Family: Chorismate synthase, AroC Phyre2 PDB 1r53 chain A Region: 1 - 369 Aligned: 267 Modelled: 287 Confidence: 100.0% Identity: 40% Fold: Chorismate synthase, AroC Superfamily: Chorismate synthase, AroC Family: Chorismate synthase, AroC Phyre2 PDB 4ecd chain B Region: 1 - 387 Aligned: 266 Modelled: 277 Confidence: 100.0% Identity: 62% PDB header:lyase Chain: B: PDB Molecule:chorismate synthase; PDBTitle: 2.5 angstrom resolution crystal structure of bifidobacterium longum2 chorismate synthase Phyre2 PDB 5z9a chain B Region: 1 - 371 Aligned: 241 Modelled: 250 Confidence: 100.0% Identity: 41% PDB header:lyase Chain: B: PDB Molecule:chorismate synthase; PDBTitle: crystal structure of chorismate synthase from pseudomonas aeruginosa Phyre2 PDB 2k1h chain A Region: 245 - 267 Aligned: 23 Modelled: 23 Confidence: 78.6% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ser13; PDBTitle: solution nmr structure of ser13 from staphylococcus epidermidis.2 northeast structural genomics consortium target ser13 Phyre2 PDB 2ffm chain A domain 1 Region: 245 - 267 Aligned: 23 Modelled: 23 Confidence: 75.6% Identity: 9% Fold: Hypothetical protein SAV1430 Superfamily: Hypothetical protein SAV1430 Family: Hypothetical protein SAV1430 Phyre2 PDB 2ltm chain A Region: 245 - 267 Aligned: 23 Modelled: 23 Confidence: 72.6% Identity: 30% PDB header:electron transport Chain: A: PDB Molecule:nfu1 iron-sulfur cluster scaffold homolog, mitochondrial; PDBTitle: solution nmr structure of nfu1 iron-sulfur cluster scaffold homolog2 from homo sapiens, northeast structural genomics consortium (nesg)3 target hr2876b Phyre2 PDB 1ciy chain A domain 1 Region: 255 - 319 Aligned: 63 Modelled: 65 Confidence: 62.9% Identity: 13% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: delta-Endotoxin, C-terminal domain Phyre2 PDB 2ltl chain A Region: 245 - 267 Aligned: 23 Modelled: 23 Confidence: 56.2% Identity: 30% PDB header:electron transport Chain: A: PDB Molecule:nifu-like protein, mitochondrial; PDBTitle: solution nmr structure of nifu-like protein from saccharomyces2 cerevisiae, northeast structural genomics consortium (nesg) target3 yr313a Phyre2 PDB 1ji6 chain A domain 1 Region: 255 - 312 Aligned: 58 Modelled: 58 Confidence: 53.1% Identity: 10% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: delta-Endotoxin, C-terminal domain Phyre2 PDB 1m1g chain B Region: 26 - 68 Aligned: 43 Modelled: 43 Confidence: 52.9% Identity: 19% PDB header:transcription Chain: B: PDB Molecule:transcription antitermination protein nusg; PDBTitle: crystal structure of aquifex aeolicus n-utilization2 substance g (nusg), space group p2(1) Phyre2 PDB 4grd chain A Region: 151 - 270 Aligned: 87 Modelled: 92 Confidence: 46.9% Identity: 29% PDB header:lyase,isomerase Chain: A: PDB Molecule:phosphoribosylaminoimidazole carboxylase catalytic subunit; PDBTitle: crystal structure of phosphoribosylaminoimidazole carboxylase2 catalytic subunit from burkholderia cenocepacia j2315 Phyre2 PDB 1dlc chain A domain 1 Region: 255 - 296 Aligned: 42 Modelled: 42 Confidence: 43.1% Identity: 10% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: delta-Endotoxin, C-terminal domain Phyre2 PDB 1o4v chain A Region: 151 - 270 Aligned: 87 Modelled: 92 Confidence: 38.5% Identity: 20% Fold: Flavodoxin-like Superfamily: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) Family: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) Phyre2 PDB 2lhu chain A Region: 85 - 131 Aligned: 26 Modelled: 26 Confidence: 37.2% Identity: 27% PDB header:structural protein Chain: A: PDB Molecule:mybpc3 protein; PDBTitle: structural insight into the unique cardiac myosin binding protein-c2 motif: a partially folded domain Phyre2 1 c1ztbA_ 2 d1qxoa_ 3 d1um0a_ 4 d1q1la_ 5 c4lj2A_ 6 d1sq1a_ 7 d1r53a_ 8 c4ecdB_ 9 c5z9aB_ 10 c2k1hA_ 11 d2ffma1 12 c2ltmA_ 13 d1ciya1 14 c2ltlA_ 15 d1ji6a1 16 c1m1gB_ 17 c4grdA_ 18 d1dlca1 19 d1o4va_ 20 c2lhuA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99