1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	T	Q	V	T	L	G	K	E	E	L	E	L	L	D	R	A	A	K	A	S	G	A	S	R	S	E	L	I	R	R	A	I	H	R	A	Y	G	T	G	S	K	Q	E	R	L	A	A	L	D	H	S	R	G	S	W	R	G	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?															?	?	?	?															?	?	?	?	?	?								?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.
Sequence		D	F	T	G	T	E	Y	V	D	A	I	R	G	D	L	N	E	R	L	A	R	L	G	L	A
Secondary structure
SS confidence
Disorder		?				?																	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 36%) Alpha helix ( 75%) Beta strand ( 0%)

Rank Aligned region

PDB 2k5j chain B Region: 1 - 75 Aligned: 71 Modelled: 75 Confidence: 99.9% Identity: 25% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein yiif; PDBTitle: solution structure of protein yiif from shigella flexneri2 serotype 5b (strain 8401) . northeast structural genomics3 consortium target sft1 Phyre2 PDB 2bj3 chain D Region: 1 - 41 Aligned: 41 Modelled: 41 Confidence: 97.7% Identity: 27% PDB header:transcription Chain: D: PDB Molecule:nickel responsive regulator; PDBTitle: nikr-apo Phyre2 PDB 2bj7 chain A domain 1 Region: 1 - 41 Aligned: 41 Modelled: 41 Confidence: 97.7% Identity: 27% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2ca9 chain B Region: 1 - 41 Aligned: 41 Modelled: 41 Confidence: 97.6% Identity: 34% PDB header:transcription Chain: B: PDB Molecule:putative nickel-responsive regulator; PDBTitle: apo-nikr from helicobacter pylori in closed trans-2 conformation Phyre2 PDB 1q5v chain B Region: 1 - 41 Aligned: 41 Modelled: 41 Confidence: 97.6% Identity: 34% PDB header:transcription Chain: B: PDB Molecule:nickel responsive regulator; PDBTitle: apo-nikr Phyre2 PDB 4me7 chain E Region: 2 - 51 Aligned: 50 Modelled: 48 Confidence: 97.3% Identity: 20% PDB header:hydrolase/hydrolase inhibitor Chain: E: PDB Molecule:antitoxin endoai; PDBTitle: crystal structure of bacillus subtilis toxin mazf in complex with2 cognate antitoxin maze Phyre2 PDB 2hza chain A domain 1 Region: 2 - 46 Aligned: 45 Modelled: 45 Confidence: 97.0% Identity: 33% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2hza chain B domain 1 Region: 2 - 40 Aligned: 39 Modelled: 39 Confidence: 96.5% Identity: 36% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 5x3t chain A Region: 3 - 46 Aligned: 44 Modelled: 44 Confidence: 95.6% Identity: 34% PDB header:antitoxin/toxin Chain: A: PDB Molecule:antitoxin vapb26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 1ea4 chain K Region: 2 - 41 Aligned: 40 Modelled: 40 Confidence: 94.9% Identity: 30% PDB header:gene regulation/dna Chain: K: PDB Molecule:transcriptional repressor copg; PDBTitle: transcriptional repressor copg/22bp dsdna complex Phyre2 PDB 2cpg chain A Region: 2 - 41 Aligned: 40 Modelled: 40 Confidence: 94.9% Identity: 30% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2k9i chain B Region: 1 - 44 Aligned: 44 Modelled: 44 Confidence: 93.2% Identity: 25% PDB header:dna binding protein Chain: B: PDB Molecule:uncharacterized protein orf56; PDBTitle: nmr structure of plasmid copy control protein orf56 from sulfolobus2 islandicus Phyre2 PDB 6iya chain D Region: 3 - 40 Aligned: 38 Modelled: 38 Confidence: 93.1% Identity: 18% PDB header:antitoxin Chain: D: PDB Molecule:transcriptional regulator copg family; PDBTitle: structure of the dna binding domain of antitoxin copaso Phyre2 PDB 2rbf chain B Region: 3 - 40 Aligned: 38 Modelled: 38 Confidence: 92.0% Identity: 24% PDB header:oxidoreductase/dna Chain: B: PDB Molecule:bifunctional protein puta; PDBTitle: structure of the ribbon-helix-helix domain of escherichia coli puta2 (puta52) complexed with operator dna (o2) Phyre2 PDB 6g1n chain B Region: 1 - 38 Aligned: 38 Modelled: 38 Confidence: 89.4% Identity: 24% PDB header:antitoxin Chain: B: PDB Molecule:antitoxin hicb; PDBTitle: crystal structure of the burkholderia pseudomallei antitoxin hicb Phyre2 PDB 4p7d chain A Region: 1 - 38 Aligned: 38 Modelled: 38 Confidence: 88.7% Identity: 16% PDB header:toxin Chain: A: PDB Molecule:antitoxin hicb3; PDBTitle: antitoxin hicb3 crystal structure Phyre2 PDB 6qeq chain D Region: 1 - 34 Aligned: 34 Modelled: 34 Confidence: 84.6% Identity: 21% PDB header:dna binding protein Chain: D: PDB Molecule:pcff; PDBTitle: pcff from enterococcus faecalis pcf10 Phyre2 PDB 5ceg chain C Region: 1 - 80 Aligned: 78 Modelled: 80 Confidence: 84.3% Identity: 21% PDB header:toxin Chain: C: PDB Molecule:addiction module antidote protein, copg/arc/metj family; PDBTitle: x-ray structure of toxin/anti-toxin complex from mesorhizobium2 opportunistum Phyre2 PDB 5yrz chain C Region: 1 - 36 Aligned: 32 Modelled: 36 Confidence: 83.1% Identity: 19% PDB header:antitoxin/hydrolase Chain: C: PDB Molecule:hicb; PDBTitle: toxin-antitoxin complex from streptococcus pneumoniae Phyre2 PDB 3h87 chain D Region: 6 - 75 Aligned: 65 Modelled: 70 Confidence: 81.9% Identity: 28% PDB header:toxin/antitoxin Chain: D: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 1 c2k5jB_ 2 c2bj3D_ 3 d2bj7a1 4 c2ca9B_ 5 c1q5vB_ 6 c4me7E_ 7 d2hzaa1 8 d2hzab1 9 c5x3tA_ 10 c1ea4K_ 11 d2cpga_ 12 c2k9iB_ 13 c6iyaD_ 14 c2rbfB_ 15 c6g1nB_ 16 c4p7dA_ 17 c6qeqD_ 18 c5cegC_ 19 c5yrzC_ 20 c3h87D_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99