1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	A	A	A	V	L	A	W	M	G	V	L	C	V	C	D	V	R	Q	R	R	L	P	N	W	L	T	L	P	G	A	G	V	I	L	L	F	A	G	L	A	G	R	G	V	P	A	L	A	G	A	A	A	L	A	G	V	Y	L
Secondary structure
SS confidence
Disorder		?																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	V	H	L	A	L	P	A	A	M	G	A	G	D	V	K	L	A	I	G	L	G	G	L	T	G	C	F	G	V	E	V	W	F	L	A	A	L	A	A	P	L	L	T	A	V	C	G	V	M	V	T	P	W	G	V	R	T	L	P
Secondary structure
SS confidence
Disorder																																																					?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.
Sequence		H	G	P	S	M	C	V	A	S	L	G	A	V	G	L	A	L	L	G
Secondary structure
SS confidence
Disorder																			?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 6%) Alpha helix ( 81%) Beta strand ( 0%) TM helix ( 73%) (View membrane topology prediction)

Rank Aligned region

PDB 3s0x chain B Region: 3 - 120 Aligned: 118 Modelled: 118 Confidence: 98.8% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:peptidase a24b, flak domain protein; PDBTitle: the crystal structure of gxgd membrane protease flak Phyre2 PDB 5a1s chain B Region: 6 - 116 Aligned: 111 Modelled: 111 Confidence: 21.0% Identity: 19% PDB header:transport protein Chain: B: PDB Molecule:citrate-sodium symporter; PDBTitle: crystal structure of the sodium-dependent citrate symporter secits2 form salmonella enterica. Phyre2 PDB 6o58 chain P Region: 113 - 132 Aligned: 20 Modelled: 20 Confidence: 14.1% Identity: 20% PDB header:transport protein Chain: P: PDB Molecule:essential mcu regulator, mitochondrial; PDBTitle: human mcu-emre complex, dimer of channel Phyre2 PDB 6o58 chain H Region: 113 - 132 Aligned: 20 Modelled: 20 Confidence: 14.1% Identity: 20% PDB header:transport protein Chain: H: PDB Molecule:essential mcu regulator, mitochondrial; PDBTitle: human mcu-emre complex, dimer of channel Phyre2 PDB 2kr6 chain A Region: 70 - 120 Aligned: 51 Modelled: 51 Confidence: 10.8% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:presenilin-1; PDBTitle: solution structure of presenilin-1 ctf subunit Phyre2 PDB 4gx5 chain D Region: 19 - 120 Aligned: 102 Modelled: 102 Confidence: 6.7% Identity: 13% PDB header:transport protein Chain: D: PDB Molecule:trka domain protein; PDBTitle: gsuk channel Phyre2 PDB 6b2z chain S Region: 120 - 136 Aligned: 17 Modelled: 17 Confidence: 6.3% Identity: 12% PDB header:membrane protein Chain: S: PDB Molecule:atp synthase subunit j, mitochondrial; PDBTitle: cryo-em structure of the dimeric fo region of yeast mitochondrial atp2 synthase Phyre2 PDB 6b2z chain I Region: 120 - 136 Aligned: 17 Modelled: 17 Confidence: 6.3% Identity: 12% PDB header:membrane protein Chain: I: PDB Molecule:atp synthase subunit c, mitochondrial; PDBTitle: cryo-em structure of the dimeric fo region of yeast mitochondrial atp2 synthase Phyre2 PDB 3w4s chain B Region: 68 - 103 Aligned: 36 Modelled: 36 Confidence: 6.0% Identity: 33% PDB header:transferase Chain: B: PDB Molecule:carbohydrate/pyrimidine kinase, pfkb family; PDBTitle: myo-inositol kinase from thermococcus kodakarensis Phyre2 1 c3s0xB_ 2 c5a1sB_ 3 c6o58P_ 4 c6o58H_ 5 c2kr6A_ 6 c4gx5D_ 7 c6b2zS_ 8 c6b2zi_ 9 c3w4sB_