1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	S	A	D	S	S	L	S	L	P	L	S	G	T	H	R	Y	R	V	T	H	R	T	E	Y	R	Y	S	D	V	V	T	S	S	Y	G	R	G	F	L	T	P	R	N	S	L	R	Q	R	C	V	A	H	R	L	T	I	D	P	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	A	D	R	S	T	S	R	D	G	Y	G	N	I	S	S	Y	F	H	V	T	E	P	H	R	T	L	T	I	T	S	D	S	I	V	D	V	S	P	P	P	P	G	L	Y	T	S	G	P	A	L	Q	P	W	E	A	A	R	P	A
Secondary structure
SS confidence
Disorder																																																										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	L	P	G	S	L	A	T	E	F	T	L	D	L	N	P	P	E	I	T	D	A	V	R	E	Y	A	A	P	S	F	L	P	K	R	P	L	V	E	V	L	R	D	L	A	S	R	I	Y	T	D	F	T	Y	R	S	G	S	T	T
Secondary structure
SS confidence
Disorder																		?																																									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	S	T	G	V	N	E	V	L	L	A	R	E	G	V	C	Q	D	F	A	R	L	A	I	A	C	L	R	A	N	G	L	A	A	C	Y	V	S	G	Y	L	A	T	D	P	P	P	G	K	D	R	M	I	G	I	D	A	T	H	A
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		W	A	S	V	W	T	P	Q	Q	P	G	R	F	E	W	L	G	L	D	P	T	N	D	Q	L	V	D	Q	R	Y	I	V	V	G	R	G	R	D	Y	A	D	V	P	P	L	R	G	I	I	Y	T	N	S	E	N	S	V	I	D	V
Secondary structure
SS confidence
Disorder																												?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.
Sequence		S	V	D	V	V	P	F	E	G	D	A	L	H	A
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 20%) Beta strand ( 36%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 3isr chain B Region: 12 - 314 Aligned: 274 Modelled: 303 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:transglutaminase-like enzymes, putative cysteine protease; PDBTitle: the crystal structure of a putative cysteine protease from cytophaga2 hutchinsonii to 1.9a Phyre2 PDB 6g49 chain A Region: 136 - 261 Aligned: 122 Modelled: 126 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:protein-glutamine gamma-glutamyltransferase; PDBTitle: crystal structure of the periplasmic domain of tgpa from pseudomonas2 aeruginosa Phyre2 PDB 4xz7 chain A Region: 140 - 267 Aligned: 111 Modelled: 116 Confidence: 99.8% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of a tgase Phyre2 PDB 2q3z chain A domain 4 Region: 140 - 261 Aligned: 117 Modelled: 122 Confidence: 99.7% Identity: 26% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 2f4m chain A domain 1 Region: 141 - 265 Aligned: 106 Modelled: 109 Confidence: 99.6% Identity: 30% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 1g0d chain A domain 4 Region: 192 - 261 Aligned: 66 Modelled: 70 Confidence: 99.6% Identity: 30% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 1vjj chain A domain 4 Region: 192 - 261 Aligned: 65 Modelled: 70 Confidence: 99.6% Identity: 34% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 1ex0 chain A domain 4 Region: 192 - 261 Aligned: 66 Modelled: 69 Confidence: 99.6% Identity: 36% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 3kd4 chain A Region: 88 - 262 Aligned: 167 Modelled: 175 Confidence: 99.4% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:putative protease; PDBTitle: crystal structure of a putative protease (bdi_1141) from2 parabacteroides distasonis atcc 8503 at 2.00 a resolution Phyre2 PDB 1x3z chain A domain 1 Region: 183 - 265 Aligned: 64 Modelled: 67 Confidence: 99.3% Identity: 27% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Transglutaminase core Phyre2 PDB 4u65 chain F Region: 141 - 259 Aligned: 107 Modelled: 119 Confidence: 99.0% Identity: 17% PDB header:transferase/hydrolase Chain: F: PDB Molecule:putative cystine protease; PDBTitle: structure of the periplasmic output domain of the legionella2 pneumophila lapd ortholog cdgs9 in complex with pseudomonas3 fluorescens lapg Phyre2 PDB 3esw chain A Region: 183 - 265 Aligned: 63 Modelled: 67 Confidence: 98.9% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:peptide-n(4)-(n-acetyl-beta-glucosaminyl)asparagine PDBTitle: complex of yeast pngase with glcnac2-iac. Phyre2 PDB 1l9m chain B Region: 192 - 261 Aligned: 65 Modelled: 70 Confidence: 98.8% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:protein-glutamine glutamyltransferase e3; PDBTitle: three-dimensional structure of the human transglutaminase 32 enzyme: binding of calcium ions change structure for3 activation Phyre2 PDB 2qsh chain A Region: 157 - 268 Aligned: 109 Modelled: 112 Confidence: 98.8% Identity: 18% PDB header:dna binding protein/dna Chain: A: PDB Molecule:dna repair protein rad4; PDBTitle: crystal structure of rad4-rad23 bound to a mismatch dna Phyre2 PDB 1kv3 chain F Region: 192 - 261 Aligned: 65 Modelled: 70 Confidence: 98.8% Identity: 31% PDB header:transferase Chain: F: PDB Molecule:protein-glutamine gamma-glutamyltransferase; PDBTitle: human tissue transglutaminase in gdp bound form Phyre2 PDB 1g0d chain A Region: 192 - 261 Aligned: 65 Modelled: 70 Confidence: 98.8% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:protein-glutamine gamma-glutamyltransferase; PDBTitle: crystal structure of red sea bream transglutaminase Phyre2 PDB 1f13 chain A Region: 192 - 261 Aligned: 65 Modelled: 70 Confidence: 98.8% Identity: 34% PDB header:coagulation factor Chain: A: PDB Molecule:cellular coagulation factor xiii zymogen; PDBTitle: recombinant human cellular coagulation factor xiii Phyre2 PDB 4fgp chain B Region: 141 - 214 Aligned: 73 Modelled: 74 Confidence: 98.0% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:periplasmic protein; PDBTitle: legionella pneumophila lapg (egta-treated) Phyre2 PDB 2pfr chain B Region: 143 - 263 Aligned: 112 Modelled: 121 Confidence: 97.5% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:arylamine n-acetyltransferase 2; PDBTitle: human n-acetyltransferase 2 Phyre2 PDB 1w4t chain A domain 1 Region: 136 - 263 Aligned: 120 Modelled: 128 Confidence: 97.3% Identity: 15% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Arylamine N-acetyltransferase Phyre2 1 c3isrB_ 2 c6g49A_ 3 c4xz7A_ 4 d2q3za4 5 d2f4ma1 6 d1g0da4 7 d1vjja4 8 d1ex0a4 9 c3kd4A_ 10 d1x3za1 11 c4u65F_ 12 c3eswA_ 13 c1l9mB_ 14 c2qshA_ 15 c1kv3F_ 16 c1g0dA_ 17 c1f13A_ 18 c4fgpB_ 19 c2pfrB_ 20 d1w4ta1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99