1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	A	S	V	R	G	E	V	L	E	V	A	L	D	H	V	V	I	E	A	A	G	V	G	Y	R	V	N	A	T	P	A	T	L	A	T	L	R	Q	G	T	E	A	R	L	I	T	A	M	I	V	R	E	D	S	M	T	L	Y
Secondary structure
SS confidence
Disorder		?	?	?																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	F	P	D	G	E	T	R	D	L	F	L	T	L	L	S	V	S	G	V	G	P	R	L	A	M	A	A	L	A	V	H	D	A	P	A	L	R	Q	V	L	A	D	G	N	V	A	A	L	T	R	V	P	G	I	G	K	R	G	A
Secondary structure
SS confidence
Disorder																			?												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	R	M	V	L	E	L	R	D	K	V	G	V	A	A	T	G	G	A	L	S	T	N	G	H	A	V	R	S	P	V	V	E	A	L	V	G	L	G	F	A	A	K	Q	A	E	E	A	T	D	T	V	L	A	A	N	H	D	A	T
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																											?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.
Sequence		T	S	S	A	L	R	S	A	L	S	L	L	G	K	A	R
Secondary structure
SS confidence
Disorder														?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 49%) Beta strand ( 19%)

Rank Aligned region

PDB 2h5x chain A Region: 1 - 195 Aligned: 183 Modelled: 195 Confidence: 100.0% Identity: 100% PDB header:dna binding protein Chain: A: PDB Molecule:holliday junction atp-dependent dna helicase ruva; PDBTitle: ruva from mycobacterium tuberculosis Phyre2 PDB 1ixr chain B Region: 1 - 192 Aligned: 190 Modelled: 192 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: B: PDB Molecule:holliday junction dna helicase ruva; PDBTitle: ruva-ruvb complex Phyre2 PDB 1hjp chain A Region: 1 - 192 Aligned: 184 Modelled: 186 Confidence: 100.0% Identity: 36% PDB header:dna recombination Chain: A: PDB Molecule:ruva; PDBTitle: holliday junction binding protein ruva from e. coli Phyre2 PDB 1d8l chain A Region: 1 - 137 Aligned: 137 Modelled: 137 Confidence: 100.0% Identity: 38% PDB header:gene regulation Chain: A: PDB Molecule:protein (holliday junction dna helicase ruva); PDBTitle: e. coli holliday junction binding protein ruva nh2 region lacking2 domain iii Phyre2 PDB 1ixr chain A Region: 1 - 133 Aligned: 133 Modelled: 133 Confidence: 100.0% Identity: 41% PDB header:hydrolase Chain: A: PDB Molecule:holliday junction dna helicase ruva; PDBTitle: ruva-ruvb complex Phyre2 PDB 1bvs chain A domain 2 Region: 64 - 134 Aligned: 71 Modelled: 71 Confidence: 99.9% Identity: 80% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: DNA helicase RuvA subunit, middle domain Phyre2 PDB 1cuk chain A domain 2 Region: 64 - 141 Aligned: 78 Modelled: 78 Confidence: 99.9% Identity: 33% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: DNA helicase RuvA subunit, middle domain Phyre2 PDB 1ixr chain A domain 1 Region: 64 - 133 Aligned: 70 Modelled: 70 Confidence: 99.9% Identity: 46% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: DNA helicase RuvA subunit, middle domain Phyre2 PDB 1cuk chain A domain 3 Region: 1 - 63 Aligned: 63 Modelled: 63 Confidence: 99.8% Identity: 41% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: DNA helicase RuvA subunit, N-terminal domain Phyre2 PDB 1bvs chain A domain 3 Region: 1 - 63 Aligned: 63 Modelled: 63 Confidence: 99.8% Identity: 83% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: DNA helicase RuvA subunit, N-terminal domain Phyre2 PDB 1ixr chain A domain 2 Region: 1 - 62 Aligned: 62 Modelled: 62 Confidence: 99.8% Identity: 35% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: DNA helicase RuvA subunit, N-terminal domain Phyre2 PDB 1cuk chain A domain 1 Region: 144 - 190 Aligned: 45 Modelled: 47 Confidence: 98.5% Identity: 27% Fold: RuvA C-terminal domain-like Superfamily: DNA helicase RuvA subunit, C-terminal domain Family: DNA helicase RuvA subunit, C-terminal domain Phyre2 PDB 1kft chain A Region: 74 - 128 Aligned: 52 Modelled: 55 Confidence: 98.4% Identity: 31% PDB header:dna binding protein Chain: A: PDB Molecule:excinuclease abc subunit c; PDBTitle: solution structure of the c-terminal domain of uvrc from e-2 coli Phyre2 PDB 1kft chain A Region: 74 - 128 Aligned: 52 Modelled: 55 Confidence: 98.4% Identity: 31% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Excinuclease UvrC C-terminal domain Phyre2 PDB 1x2i chain A domain 1 Region: 63 - 131 Aligned: 65 Modelled: 69 Confidence: 98.3% Identity: 22% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 1dgs chain A domain 1 Region: 71 - 161 Aligned: 72 Modelled: 72 Confidence: 98.2% Identity: 29% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: NAD+-dependent DNA ligase, domain 3 Phyre2 PDB 2bgw chain A domain 1 Region: 63 - 131 Aligned: 66 Modelled: 69 Confidence: 98.2% Identity: 23% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 2i1q chain A domain 1 Region: 74 - 129 Aligned: 53 Modelled: 56 Confidence: 98.1% Identity: 30% Fold: SAM domain-like Superfamily: Rad51 N-terminal domain-like Family: DNA repair protein Rad51, N-terminal domain Phyre2 PDB 1ixs chain A Region: 144 - 192 Aligned: 49 Modelled: 49 Confidence: 98.0% Identity: 31% Fold: RuvA C-terminal domain-like Superfamily: DNA helicase RuvA subunit, C-terminal domain Family: DNA helicase RuvA subunit, C-terminal domain Phyre2 PDB 1pzn chain A domain 1 Region: 74 - 129 Aligned: 53 Modelled: 56 Confidence: 98.0% Identity: 25% Fold: SAM domain-like Superfamily: Rad51 N-terminal domain-like Family: DNA repair protein Rad51, N-terminal domain Phyre2 1 c2h5xA_ 2 c1ixrB_ 3 c1hjpA_ 4 c1d8lA_ 5 c1ixrA_ 6 d1bvsa2 7 d1cuka2 8 d1ixra1 9 d1cuka3 10 d1bvsa3 11 d1ixra2 12 d1cuka1 13 c1kftA_ 14 d1kfta_ 15 d1x2ia1 16 d1dgsa1 17 d2bgwa1 18 d2i1qa1 19 d1ixsa_ 20 d1pzna1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258