1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	V	M	G	V	D	P	G	L	T	R	C	G	L	S	L	I	E	S	G	R	G	R	Q	L	T	A	L	D	V	D	V	V	R	T	P	S	D	A	A	L	A	Q	R	L	L	A	I	S	D	A	V	E	H	W	L	D	T	H
Secondary structure
SS confidence
Disorder		?																																					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	P	E	V	V	A	I	E	R	V	F	S	Q	L	N	V	T	T	V	M	G	T	A	Q	A	G	G	V	I	A	L	A	A	A	K	R	G	V	D	V	H	F	H	T	P	S	E	V	K	A	A	V	T	G	N	G	S	A	D	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	Q	V	T	A	M	V	T	K	I	L	A	L	Q	A	K	P	T	P	A	D	A	A	D	A	L	A	L	A	I	C	H	C	W	R	A	P	T	I	A	R	M	A	E	A	T	S	R	A	E	A	R	A	A	Q	Q	R	H	A	Y
Secondary structure
SS confidence
Disorder																																							?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		L	A	K	L	K	A	A	R
Secondary structure
SS confidence
Disorder							?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 51%) Beta strand ( 17%)

Rank Aligned region

PDB 1hjr chain A Region: 2 - 156 Aligned: 152 Modelled: 155 Confidence: 100.0% Identity: 40% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: RuvC resolvase Phyre2 PDB 4ep5 chain A Region: 1 - 157 Aligned: 148 Modelled: 157 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: A: PDB Molecule:crossover junction endodeoxyribonuclease ruvc; PDBTitle: thermus thermophilus ruvc structure Phyre2 PDB 4ktz chain B Region: 2 - 150 Aligned: 143 Modelled: 149 Confidence: 98.7% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:ruvc endonuclease; PDBTitle: lactococcus phage 67 ruvc Phyre2 PDB 1kcf chain A domain 2 Region: 2 - 151 Aligned: 147 Modelled: 150 Confidence: 98.5% Identity: 14% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Mitochondrial resolvase ydc2 catalytic domain Phyre2 PDB 3bzk chain A domain 5 Region: 2 - 67 Aligned: 59 Modelled: 66 Confidence: 98.2% Identity: 22% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Tex RuvX-like domain-like Phyre2 PDB 1vhx chain A Region: 1 - 103 Aligned: 94 Modelled: 103 Confidence: 98.2% Identity: 13% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Putative Holliday junction resolvase RuvX Phyre2 PDB 1kcf chain B Region: 1 - 151 Aligned: 143 Modelled: 151 Confidence: 98.1% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:hypothetical 30.2 kd protein c25g10.02 in PDBTitle: crystal structure of the yeast mitochondrial holliday2 junction resolvase, ydc2 Phyre2 PDB 1nu0 chain A Region: 2 - 103 Aligned: 91 Modelled: 99 Confidence: 97.9% Identity: 16% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Putative Holliday junction resolvase RuvX Phyre2 PDB 1iv0 chain A Region: 1 - 67 Aligned: 57 Modelled: 67 Confidence: 97.8% Identity: 18% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Putative Holliday junction resolvase RuvX Phyre2 PDB 2oce chain A Region: 2 - 67 Aligned: 58 Modelled: 66 Confidence: 97.3% Identity: 26% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein pa5201; PDBTitle: crystal structure of tex family protein pa5201 from2 pseudomonas aeruginosa Phyre2 PDB 6joo chain A Region: 3 - 33 Aligned: 31 Modelled: 31 Confidence: 97.0% Identity: 29% PDB header:hydrolase/dna/rna Chain: A: PDB Molecule:crispr-associated protein,crispr-associated endonuclease PDBTitle: crystal structure of corynebacterium diphtheriae cas9 in complex with2 sgrna and target dna Phyre2 PDB 5x2h chain A Region: 2 - 55 Aligned: 49 Modelled: 54 Confidence: 96.9% Identity: 22% PDB header:hydrolase/rna/dna Chain: A: PDB Molecule:crispr-associated endonuclease cas9; PDBTitle: crystal structure of campylobacter jejuni cas9 in complex with sgrna2 and target dna (agaaaca pam) Phyre2 PDB 5axw chain A Region: 3 - 60 Aligned: 55 Modelled: 58 Confidence: 96.6% Identity: 15% PDB header:hydrolase/rna/dna Chain: A: PDB Molecule:crispr-associated endonuclease cas9; PDBTitle: crystal structure of staphylococcus aureus cas9 in complex with sgrna2 and target dna (ttgggt pam) Phyre2 PDB 1saz chain A domain 1 Region: 1 - 108 Aligned: 106 Modelled: 108 Confidence: 96.5% Identity: 16% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Acetokinase-like Phyre2 PDB 4oge chain A Region: 4 - 33 Aligned: 30 Modelled: 30 Confidence: 96.3% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:hnh endonuclease domain protein; PDBTitle: crystal structure of the type ii-c cas9 enzyme from actinomyces2 naeslundii Phyre2 PDB 4cmq chain B Region: 3 - 63 Aligned: 61 Modelled: 61 Confidence: 96.1% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:crispr-associated endonuclease cas9/csn1; PDBTitle: crystal structure of mn-bound s.pyogenes cas9 Phyre2 PDB 1okj chain A domain 1 Region: 2 - 108 Aligned: 96 Modelled: 107 Confidence: 95.2% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: YeaZ-like Phyre2 PDB 6gmh chain M Region: 2 - 67 Aligned: 60 Modelled: 61 Confidence: 95.2% Identity: 20% PDB header:transcription Chain: M: PDB Molecule:transcription elongation factor spt6,transcription PDBTitle: structure of activated transcription complex pol ii-dsif-paf-spt6 Phyre2 PDB 1okj chain B Region: 1 - 108 Aligned: 97 Modelled: 108 Confidence: 95.1% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:trna threonylcarbamoyladenosine biosynthesis protein tsab; PDBTitle: crystal structure of the essential e. coli yeaz2 protein by mad method using the gadolinium complex3 "dotma" Phyre2 PDB 3eo3 chain B Region: 1 - 59 Aligned: 53 Modelled: 59 Confidence: 95.1% Identity: 15% PDB header:isomerase, transferase Chain: B: PDB Molecule:bifunctional udp-n-acetylglucosamine 2-epimerase/n- PDBTitle: crystal structure of the n-acetylmannosamine kinase domain of human2 gne protein Phyre2 1 d1hjra_ 2 c4ep5A_ 3 c4ktzB_ 4 d1kcfa2 5 d3bzka5 6 d1vhxa_ 7 c1kcfB_ 8 d1nu0a_ 9 d1iv0a_ 10 c2oceA_ 11 c6jooA_ 12 c5x2hA_ 13 c5axwA_ 14 d1saza1 15 c4ogeA_ 16 c4cmqB_ 17 d1okja1 18 c6gmhM_ 19 c1okjB_ 20 c3eo3B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167