1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	I	A	P	D	T	S	V	L	V	A	G	F	A	T	W	H	E	G	H	E	A	A	V	R	A	L	N	R	G	V	H	L	I	A	H	A	A	V	E	T	Y	S	V	L	T	R	L	P	P	P	H	R	I	A	P	V	A	V	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?									?	?	?		?										?					?																?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	Y	L	A	D	I	T	S	S	N	Y	L	A	L	D	A	C	S	Y	R	G	L	T	D	H	L	A	E	H	D	V	T	G	G	A	T	Y	D	A	L	V	G	F	T	A	K	A	A	G	A	K	L	L	T	R	D	L	R	A	V
Secondary structure
SS confidence
Disorder								?		?	?	?	?	?																?																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.
Sequence		E	T	Y	E	R	L	R	V	E	V	E	L	V	T
Secondary structure
SS confidence
Disorder											?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 62%) Beta strand ( 3%)

Rank Aligned region

PDB 5l6m chain C Region: 3 - 131 Aligned: 125 Modelled: 129 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 3tnd chain C Region: 2 - 131 Aligned: 126 Modelled: 130 Confidence: 99.9% Identity: 14% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 6nkl chain A Region: 1 - 131 Aligned: 127 Modelled: 131 Confidence: 99.9% Identity: 11% PDB header:antitoxin Chain: A: PDB Molecule:ribonuclease vapc; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 2h1c chain A domain 1 Region: 1 - 131 Aligned: 131 Modelled: 131 Confidence: 99.9% Identity: 16% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 3zvk chain C Region: 1 - 131 Aligned: 126 Modelled: 131 Confidence: 99.9% Identity: 12% PDB header:antitoxin/toxin/dna Chain: C: PDB Molecule:toxin of toxin-antitoxin system; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 5x3t chain D Region: 2 - 129 Aligned: 125 Modelled: 127 Confidence: 99.8% Identity: 14% PDB header:antitoxin/toxin Chain: D: PDB Molecule:ribonuclease vapc26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 5wzf chain B Region: 2 - 128 Aligned: 122 Modelled: 127 Confidence: 99.8% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:23s rrna-specific endonuclease vapc20; PDBTitle: crystal structure of mycobacterium tuberculosis vapc20 (rv2549c),2 sarcin-ricin loop cleaving toxin Phyre2 PDB 1v96 chain A domain 1 Region: 2 - 130 Aligned: 120 Modelled: 129 Confidence: 99.8% Identity: 16% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 4xgr chain G Region: 1 - 128 Aligned: 124 Modelled: 126 Confidence: 99.8% Identity: 15% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 3dbo chain B Region: 2 - 133 Aligned: 120 Modelled: 132 Confidence: 99.8% Identity: 19% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 PDB 3h87 chain B Region: 3 - 132 Aligned: 122 Modelled: 130 Confidence: 99.7% Identity: 16% PDB header:toxin/antitoxin Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 6a7v chain G Region: 2 - 131 Aligned: 124 Modelled: 130 Confidence: 99.7% Identity: 21% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 2fe1 chain A domain 1 Region: 2 - 126 Aligned: 122 Modelled: 125 Confidence: 99.7% Identity: 21% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 2fe1 chain A Region: 2 - 126 Aligned: 122 Modelled: 125 Confidence: 99.7% Identity: 21% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein pae0151; PDBTitle: crystal structure of pae0151 from pyrobaculum aerophilum Phyre2 PDB 1y82 chain A domain 1 Region: 2 - 130 Aligned: 122 Modelled: 129 Confidence: 99.7% Identity: 16% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 4chg chain C Region: 3 - 130 Aligned: 122 Modelled: 128 Confidence: 99.7% Identity: 17% PDB header:toxin/antitoxin Chain: C: PDB Molecule:probable ribonuclease vapc15; PDBTitle: crystal structure of vapbc15 complex from mycobacterium tuberculosis Phyre2 PDB 5sv2 chain A Region: 3 - 126 Aligned: 115 Modelled: 124 Confidence: 99.6% Identity: 9% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease vapc21; PDBTitle: toxin vapc21 from mycobacterium tuberculosis Phyre2 PDB 1v8p chain A Region: 3 - 125 Aligned: 114 Modelled: 123 Confidence: 99.5% Identity: 20% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1v8p chain K Region: 3 - 125 Aligned: 114 Modelled: 123 Confidence: 99.5% Identity: 20% PDB header:structural genomics, unknown function Chain: K: PDB Molecule:hypothetical protein pae2754; PDBTitle: crystal structure of pae2754 from pyrobaculum aerophilum Phyre2 PDB 1w8i chain A Region: 3 - 120 Aligned: 113 Modelled: 118 Confidence: 99.2% Identity: 17% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 1 c5l6mC_ 2 c3tndC_ 3 c6nklA_ 4 d2h1ca1 5 c3zvkC_ 6 c5x3tD_ 7 c5wzfB_ 8 d1v96a1 9 c4xgrG_ 10 c3dboB_ 11 c3h87B_ 12 c6a7vG_ 13 d2fe1a1 14 c2fe1A_ 15 d1y82a1 16 c4chgC_ 17 c5sv2A_ 18 d1v8pa_ 19 c1v8pK_ 20 d1w8ia_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44