1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	F	A	V	L	P	P	E	V	N	S	A	R	I	F	A	G	A	G	L	G	P	M	L	A	A	A	S	A	W	D	G	L	A	E	E	L	H	A	A	A	G	S	F	A	S	V	T	T	G	L	A	G	D	A	W	H	G	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?										?					?																															?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	S	L	A	M	T	R	A	A	S	P	Y	V	G	W	L	N	T	A	A	G	Q	A	A	Q	A	A	G	Q	A	R	L	A	A	S	A	F	E	A	T	L	A	A	T	V	S	P	A	M	V	A	A	N	R	T	R	L	A	S	L
Secondary structure
SS confidence
Disorder																																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	A	A	N	L	L	G	Q	N	A	P	A	I	A	A	A	E	A	E	Y	E	Q	I	W	A	Q	D	V	A	A	M	F	G	Y	H	S	A	A	S	A	V	A	T	Q	L	A	P	I	Q	E	G	L	Q	Q	Q	L	Q	N	V	L
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	Q	L	A	S	G	N	L	G	S	G	N	V	G	V	G	N	I	G	N	D	N	I	G	N	A	N	I	G	F	G	N	R	G	D	A	N	I	G	I	G	N	I	G	D	R	N	L	G	I	G	N	T	G	N	W	N	I	G	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																							?		?				?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	I	T	G	N	G	Q	I	G	F	G	K	P	A	N	P	D	V	L	V	V	G	N	G	G	P	G	V	T	A	L	V	M	G	G	T	D	S	L	L	P	L	P	N	I	P	L	L	E	Y	A	A	R	F	I	T	P	V	H	P
Secondary structure
SS confidence
Disorder			?	?		?											?	?	?	?	?	?		?	?	?		?										?	?	?	?	?			?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	Y	T	A	T	F	L	E	T	P	S	Q	F	F	P	F	T	G	L	N	S	L	T	Y	D	V	S	V	A	Q	G	V	T	N	L	H	T	A	I	M	A	Q	L	A	A	G	N	E	V	V	V	F	G	T	S	Q	S	A	T	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	T	F	E	M	R	Y	L	Q	S	L	P	A	H	L	R	P	G	L	D	E	L	S	F	T	L	T	G	N	P	N	R	P	D	G	G	I	L	T	R	F	G	F	S	I	P	Q	L	G	F	T	L	S	G	A	T	P	A	D	A
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		Y	P	T	V	D	Y	A	F	Q	Y	D	G	V	N	D	F	P	K	Y	P	L	N	V	F	A	T	A	N	A	I	A	G	I	L	F	L	H	S	G	L	I	A	L	P	P	D	L	A	S	G	V	V	Q	P	V	S	S	P	D	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		L	T	T	Y	I	L	L	P	S	Q	D	L	P	L	L	V	P	L	R	A	I	P	L	L	G	N	P	L	A	D	L	I	Q	P	D	L	R	V	L	V	E	L	G	Y	D	R	T	A	H	Q	D	V	P	S	P	F	G	L	F	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580
Sequence		D	V	D	W	A	E	V	A	A	D	L	Q	Q	G	A	V	Q	G	V	N	D	A	L	S	G	L	G	L	P	P	P	W	Q	P	A	L	P	R	L	F
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 39%) Beta strand ( 5%)

Rank Aligned region

PDB 5xfs chain B Region: 1 - 174 Aligned: 173 Modelled: 174 Confidence: 100.0% Identity: 55% PDB header:protein transport Chain: B: PDB Molecule:ppe family protein ppe15; PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis Phyre2 PDB 2g38 chain B Region: 3 - 173 Aligned: 170 Modelled: 171 Confidence: 100.0% Identity: 35% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:ppe family protein; PDBTitle: a pe/ppe protein complex from mycobacterium tuberculosis Phyre2 PDB 2g38 chain B domain 1 Region: 3 - 173 Aligned: 170 Modelled: 171 Confidence: 100.0% Identity: 35% Fold: Ferritin-like Superfamily: PE/PPE dimer-like Family: PPE Phyre2 PDB 4xy3 chain A Region: 4 - 171 Aligned: 151 Modelled: 168 Confidence: 100.0% Identity: 17% PDB header:protein transport Chain: A: PDB Molecule:esx-1 secretion-associated protein espb; PDBTitle: structure of esx-1 secreted protein espb Phyre2 PDB 3aja chain A Region: 304 - 472 Aligned: 167 Modelled: 169 Confidence: 99.8% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of msmeg_6394 Phyre2 PDB 1qoz chain A Region: 270 - 440 Aligned: 166 Modelled: 171 Confidence: 99.4% Identity: 17% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Cutinase-like Phyre2 PDB 1g66 chain A Region: 271 - 440 Aligned: 165 Modelled: 170 Confidence: 99.3% Identity: 16% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Cutinase-like Phyre2 PDB 3hc7 chain A Region: 269 - 438 Aligned: 158 Modelled: 170 Confidence: 99.2% Identity: 20% PDB header:cell adhesion Chain: A: PDB Molecule:gene 12 protein; PDBTitle: crystal structure of lysin b from mycobacteriophage d29 Phyre2 PDB 2czq chain B Region: 270 - 448 Aligned: 161 Modelled: 176 Confidence: 99.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:cutinase-like protein; PDBTitle: a novel cutinase-like protein from cryptococcus sp. Phyre2 PDB 3dd5 chain F Region: 271 - 460 Aligned: 151 Modelled: 161 Confidence: 98.8% Identity: 13% PDB header:hydrolase Chain: F: PDB Molecule:cutinase; PDBTitle: glomerella cingulata e600-cutinase complex Phyre2 PDB 1cex chain A Region: 287 - 441 Aligned: 129 Modelled: 139 Confidence: 98.8% Identity: 10% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Cutinase-like Phyre2 PDB 5x88 chain A Region: 305 - 435 Aligned: 105 Modelled: 115 Confidence: 98.7% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:cutinase; PDBTitle: a crystal structure of cutinases from malbranchea cinnamomea Phyre2 PDB 3gbs chain A Region: 270 - 460 Aligned: 154 Modelled: 175 Confidence: 98.6% Identity: 8% PDB header:hydrolase Chain: A: PDB Molecule:cutinase 1; PDBTitle: crystal structure of aspergillus oryzae cutinase Phyre2 PDB 4oyl chain C Region: 270 - 435 Aligned: 140 Modelled: 150 Confidence: 98.4% Identity: 13% PDB header:hydrolase Chain: C: PDB Molecule:cutinase; PDBTitle: humicola insolens cutinase in complex with mono-ethylphosphate Phyre2 PDB 4psd chain A Region: 305 - 435 Aligned: 99 Modelled: 112 Confidence: 98.4% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:carbohydrate esterase family 5; PDBTitle: structure of trichoderma reesei cutinase native form. Phyre2 PDB 4wj2 chain A Region: 14 - 110 Aligned: 92 Modelled: 92 Confidence: 98.2% Identity: 18% PDB header:unknown function Chain: A: PDB Molecule:antigen mtb48; PDBTitle: mycobacterial protein Phyre2 PDB 2vs0 chain B Region: 21 - 100 Aligned: 79 Modelled: 80 Confidence: 97.6% Identity: 11% PDB header:cell invasion Chain: B: PDB Molecule:virulence factor esxa; PDBTitle: structural analysis of homodimeric staphylococcal aureus2 virulence factor esxa Phyre2 PDB 4iog chain D Region: 21 - 100 Aligned: 79 Modelled: 80 Confidence: 97.4% Identity: 13% PDB header:unknown function Chain: D: PDB Molecule:secreted protein esxb; PDBTitle: the crystal structure of a secreted protein esxb (wild-type, in p212 space group) from bacillus anthracis str. sterne Phyre2 PDB 3gvm chain A Region: 21 - 100 Aligned: 79 Modelled: 80 Confidence: 97.3% Identity: 10% PDB header:viral protein Chain: A: PDB Molecule:putative uncharacterized protein sag1039; PDBTitle: structure of the homodimeric wxg-100 family protein from streptococcus2 agalactiae Phyre2 PDB 3zbh chain C Region: 21 - 100 Aligned: 79 Modelled: 80 Confidence: 97.2% Identity: 15% PDB header:unknown function Chain: C: PDB Molecule:esxa; PDBTitle: geobacillus thermodenitrificans esxa crystal form i Phyre2 1 c5xfsB_ 2 c2g38B_ 3 d2g38b1 4 c4xy3A_ 5 c3ajaA_ 6 d1qoza_ 7 d1g66a_ 8 c3hc7A_ 9 c2czqB_ 10 c3dd5F_ 11 d1cexa_ 12 c5x88A_ 13 c3gbsA_ 14 c4oylC_ 15 c4psdA_ 16 c4wj2A_ 17 c2vs0B_ 18 c4iogD_ 19 c3gvmA_ 20 c3zbhC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130