1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	I	A	G	L	K	G	L	K	L	P	K	D	P	R	S	S	V	T	R	T	A	T	D	W	A	Y	A	A	G	W	M	A	V	R	A	L	P	E	F	A	V	R	N	A	F	D	T	G	A	R	Y	F	A	R	H	G	G	P	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	L	R	K	N	L	A	R	V	L	G	V	P	P	A	A	V	P	D	P	L	M	C	A	S	L	E	S	Y	G	R	Y	W	R	E	V	F	R	L	P	T	I	N	H	R	K	L	A	R	Q	L	D	R	V	I	G	G	L	D	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	D	A	A	L	A	A	G	L	G	A	V	L	A	L	P	H	S	G	N	W	D	M	A	G	M	W	L	V	Q	R	H	G	T	F	T	T	V	A	E	R	L	K	P	E	S	L	Y	Q	R	F	I	D	Y	R	E	S	L	G	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	V	L	P	L	S	G	G	E	R	P	P	F	E	V	L	S	E	R	L	R	N	N	R	V	V	C	L	M	A	E	R	D	L	T	R	T	G	V	E	V	D	F	F	G	E	P	T	R	M	P	V	G	P	A	K	L	A	V	E
Secondary structure
SS confidence
Disorder									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	G	A	A	L	L	P	T	H	C	W	F	E	G	R	G	W	G	F	Q	V	Y	P	A	L	D	C	T	S	G	D	V	A	A	I	T	Q	A	L	A	D	R	F	A	Q	N	I	A	A	H	P	A	D	W	H	M	L	Q	P	Q
Secondary structure
SS confidence
Disorder																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.
Sequence		W	L	A	D	L	S	E	S	R	R	A	Q	L	R	S	R
Secondary structure
SS confidence
Disorder														?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 53%) Beta strand ( 16%) TM helix ( 27%) (View membrane topology prediction)

Rank Aligned region

PDB 5knk chain B Region: 25 - 306 Aligned: 276 Modelled: 282 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:lipid a biosynthesis lauroyl acyltransferase; PDBTitle: lipid a secondary acyltransferase lpxm from acinetobacter baumannii2 with catalytic residue substitution (e127a) Phyre2 PDB 5f34 chain A Region: 60 - 313 Aligned: 252 Modelled: 254 Confidence: 100.0% Identity: 77% PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol mannoside acyltransferase; PDBTitle: crystal structure of membrane associated pata from mycobacterium2 smegmatis in complex with s-hexadecyl coenzyme a - p21 space group Phyre2 PDB 5kym chain A Region: 39 - 294 Aligned: 225 Modelled: 256 Confidence: 98.8% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:1-acyl-sn-glycerol-3-phosphate acyltransferase; PDBTitle: crystal structure of the 1-acyl-sn-glycerophosphate (lpa)2 acyltransferase, plsc, from thermotoga maritima Phyre2 PDB 4nmn chain A Region: 121 - 249 Aligned: 129 Modelled: 129 Confidence: 53.6% Identity: 9% PDB header:replication Chain: A: PDB Molecule:replicative dna helicase; PDBTitle: aquifex aeolicus replicative helicase (dnab) complexed with adp, at2 3.3 resolution Phyre2 PDB 4p7d chain A Region: 245 - 293 Aligned: 49 Modelled: 46 Confidence: 45.2% Identity: 16% PDB header:toxin Chain: A: PDB Molecule:antitoxin hicb3; PDBTitle: antitoxin hicb3 crystal structure Phyre2 PDB 2j5b chain A Region: 105 - 141 Aligned: 36 Modelled: 37 Confidence: 43.8% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:tyrosyl-trna synthetase; PDBTitle: structure of the tyrosyl trna synthetase from acanthamoeba polyphaga2 mimivirus complexed with tyrosynol Phyre2 PDB 1ltx chain A Region: 266 - 301 Aligned: 36 Modelled: 36 Confidence: 39.0% Identity: 14% PDB header:transferase/protein binding Chain: A: PDB Molecule:rab geranylgeranyltransferase alpha subunit; PDBTitle: structure of rab escort protein-1 in complex with rab geranylgeranyl2 transferase and isoprenoid Phyre2 PDB 1qop chain B Region: 120 - 201 Aligned: 82 Modelled: 82 Confidence: 38.6% Identity: 18% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1vli chain A domain 2 Region: 115 - 207 Aligned: 91 Modelled: 93 Confidence: 38.4% Identity: 15% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: NeuB-like Phyre2 PDB 1v8z chain A domain 1 Region: 120 - 201 Aligned: 82 Modelled: 82 Confidence: 37.0% Identity: 18% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 2zy4 chain F Region: 236 - 293 Aligned: 56 Modelled: 58 Confidence: 36.3% Identity: 29% PDB header:lyase Chain: F: PDB Molecule:l-aspartate beta-decarboxylase; PDBTitle: dodecameric l-aspartate beta-decarboxylase Phyre2 PDB 4qys chain A Region: 120 - 210 Aligned: 91 Modelled: 90 Confidence: 36.0% Identity: 12% PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase beta chain 2; PDBTitle: trpb2 enzymes Phyre2 PDB 1r6t chain A domain 2 Region: 107 - 141 Aligned: 35 Modelled: 35 Confidence: 36.0% Identity: 17% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 3cwc chain B Region: 230 - 288 Aligned: 59 Modelled: 59 Confidence: 36.0% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:putative glycerate kinase 2; PDBTitle: crystal structure of putative glycerate kinase 2 from salmonella2 typhimurium lt2 Phyre2 PDB 1r6u chain B Region: 107 - 141 Aligned: 35 Modelled: 35 Confidence: 35.3% Identity: 17% PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structure of an active fragment of human tryptophanyl-trna2 synthetase with cytokine activity Phyre2 PDB 1v71 chain A domain 1 Region: 120 - 208 Aligned: 86 Modelled: 89 Confidence: 30.8% Identity: 14% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 3lub chain E Region: 118 - 140 Aligned: 23 Modelled: 23 Confidence: 29.4% Identity: 22% PDB header:hydrolase Chain: E: PDB Molecule:putative creatinine amidohydrolase; PDBTitle: crystal structure of putative creatinine amidohydrolase (yp_211512.1)2 from bacteroides fragilis nctc 9343 at 2.11 a resolution Phyre2 PDB 3kt3 chain D Region: 107 - 141 Aligned: 35 Modelled: 35 Confidence: 27.5% Identity: 17% PDB header:ligase Chain: D: PDB Molecule:tryptophanyl-trna synthetase, cytoplasmic; PDBTitle: crystal structure of s. cerevisiae tryptophanyl-trna synthetase in2 complex with trpamp Phyre2 PDB 4wbd chain A Region: 191 - 292 Aligned: 102 Modelled: 102 Confidence: 27.0% Identity: 13% PDB header:ligase Chain: A: PDB Molecule:bshc; PDBTitle: the crystal structure of bshc from bacillus subtilis complexed with2 citrate and adp Phyre2 PDB 2qui chain B Region: 83 - 141 Aligned: 59 Modelled: 59 Confidence: 26.8% Identity: 14% PDB header:ligase Chain: B: PDB Molecule:tryptophanyl-trna synthetase; PDBTitle: crystal structures of human tryptophanyl-trna synthetase in2 complex with tryptophanamide and atp Phyre2 1 c5knkB_ 2 c5f34A_ 3 c5kymA_ 4 c4nmnA_ 5 c4p7dA_ 6 c2j5bA_ 7 c1ltxA_ 8 d1qopb_ 9 d1vlia2 10 d1v8za1 11 c2zy4F_ 12 c4qysA_ 13 d1r6ta2 14 c3cwcB_ 15 c1r6uB_ 16 d1v71a1 17 c3lubE_ 18 c3kt3D_ 19 c4wbdA_ 20 c2quiB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99