1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	D	E	D	R	T	D	R	A	T	E	D	H	T	I	F	D	R	G	V	G	Q	R	D	Q	L	Q	R	L	W	T	P	Y	R	M	N	Y	L	A	E	A	P	V	K	R	D	P	N	S	S	A	S	P	A	Q	P	F	T	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?																	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	P	Q	L	S	D	E	E	G	L	V	V	A	R	G	K	L	V	Y	A	V	L	N	L	Y	P	Y	N	P	G	H	L	M	V	V	P	Y	R	R	V	S	E	L	E	D	L	T	D	L	E	S	A	E	L	M	A	F	T	Q	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	I	R	V	I	K	N	V	S	R	P	H	G	F	N	V	G	L	N	L	G	T	S	A	G	G	S	L	A	E	H	L	H	V	H	V	V	P	R	W	G	G	D	A	N	F	I	T	I	I	G	G	S	K	V	I	P	Q	L	L
Secondary structure
SS confidence
Disorder																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.
Sequence		R	D	T	R	R	L	L	A	T	E	W	A	R	Q	P
Secondary structure
SS confidence
Disorder														?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 27%) Beta strand ( 16%)

Rank Aligned region

PDB 3ano chain A Region: 14 - 195 Aligned: 158 Modelled: 163 Confidence: 100.0% Identity: 100% PDB header:transferase Chain: A: PDB Molecule:ap-4-a phosphorylase; PDBTitle: crystal structure of a novel diadenosine 5',5'''-p1,p4-tetraphosphate2 phosphorylase from mycobacterium tuberculosis h37rv Phyre2 PDB 3ksv chain A Region: 53 - 194 Aligned: 140 Modelled: 142 Confidence: 100.0% Identity: 21% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: hypothetical protein from leishmania major Phyre2 PDB 3l7x chain A Region: 35 - 192 Aligned: 151 Modelled: 158 Confidence: 100.0% Identity: 23% PDB header:cell cycle Chain: A: PDB Molecule:putative hit-like protein involved in cell-cycle PDBTitle: the crystal structure of smu.412c from streptococcus mutans ua159 Phyre2 PDB 3imi chain B Region: 53 - 192 Aligned: 138 Modelled: 140 Confidence: 100.0% Identity: 23% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hit family protein; PDBTitle: 2.01 angstrom resolution crystal structure of a hit family protein2 from bacillus anthracis str. 'ames ancestor' Phyre2 PDB 1y23 chain A Region: 54 - 192 Aligned: 137 Modelled: 139 Confidence: 100.0% Identity: 25% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 2eo4 chain A Region: 56 - 194 Aligned: 137 Modelled: 139 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:150aa long hypothetical histidine triad nucleotide-binding PDBTitle: crystal structure of hypothetical histidine triad nucleotide-binding2 protein st2152 from sulfolobus tokodaii strain7 Phyre2 PDB 6iq1 chain A Region: 55 - 194 Aligned: 138 Modelled: 140 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:adenosine 5'-monophosphoramidase; PDBTitle: crystal structure of histidine triad nucleotide-binding protein from2 candida albicans Phyre2 PDB 3lb5 chain B Region: 53 - 191 Aligned: 131 Modelled: 139 Confidence: 100.0% Identity: 21% PDB header:cell cycle Chain: B: PDB Molecule:hit-like protein involved in cell-cycle regulation; PDBTitle: crystal structure of hit-like protein involved in cell-cycle2 regulation from bartonella henselae with unknown ligand Phyre2 PDB 5cs2 chain A Region: 51 - 193 Aligned: 128 Modelled: 143 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:histidine triad protein; PDBTitle: crystal structure of plasmodium falciparum diadenosine triphosphate2 hydrolase in complex with cyclomarin a Phyre2 PDB 1ems chain B Region: 51 - 180 Aligned: 129 Modelled: 130 Confidence: 100.0% Identity: 24% PDB header:antitumor protein Chain: B: PDB Molecule:nit-fragile histidine triad fusion protein; PDBTitle: crystal structure of the c. elegans nitfhit protein Phyre2 PDB 3o0m chain B Region: 55 - 190 Aligned: 134 Modelled: 136 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:hit family protein; PDBTitle: crystal structure of a zn-bound histidine triad family protein from2 mycobacterium smegmatis Phyre2 PDB 1zwj chain A Region: 20 - 190 Aligned: 165 Modelled: 171 Confidence: 100.0% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative galactose-1-phosphate uridyl transferase; PDBTitle: x-ray structure of galt-like protein from arabidopsis thaliana2 at5g18200 Phyre2 PDB 1gup chain C Region: 20 - 189 Aligned: 170 Modelled: 170 Confidence: 100.0% Identity: 16% PDB header:nucleotidyltransferase Chain: C: PDB Molecule:galactose-1-phosphate uridylyltransferase; PDBTitle: structure of nucleotidyltransferase complexed with udp-2 galactose Phyre2 PDB 3p0t chain B Region: 53 - 194 Aligned: 134 Modelled: 142 Confidence: 100.0% Identity: 25% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an hit-like protein from mycobacterium2 paratuberculosis Phyre2 PDB 5in3 chain A Region: 20 - 189 Aligned: 169 Modelled: 170 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:galactose-1-phosphate uridylyltransferase; PDBTitle: crystal structure of glucose-1-phosphate bound nucleotidylated human2 galactose-1-phosphate uridylyltransferase Phyre2 PDB 1ems chain A domain 1 Region: 48 - 189 Aligned: 129 Modelled: 141 Confidence: 100.0% Identity: 24% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 1z84 chain A domain 2 Region: 39 - 190 Aligned: 146 Modelled: 152 Confidence: 100.0% Identity: 14% Fold: HIT-like Superfamily: HIT-like Family: Hexose-1-phosphate uridylyltransferase Phyre2 PDB 1guq chain A domain 2 Region: 39 - 189 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 16% Fold: HIT-like Superfamily: HIT-like Family: Hexose-1-phosphate uridylyltransferase Phyre2 PDB 1fit chain A Region: 67 - 192 Aligned: 117 Modelled: 126 Confidence: 100.0% Identity: 30% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 2oik chain A domain 1 Region: 53 - 193 Aligned: 130 Modelled: 141 Confidence: 100.0% Identity: 25% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 1 c3anoA_ 2 c3ksvA_ 3 c3l7xA_ 4 c3imiB_ 5 d1y23a_ 6 c2eo4A_ 7 c6iq1A_ 8 c3lb5B_ 9 c5cs2A_ 10 c1emsB_ 11 c3o0mB_ 12 c1zwjA_ 13 c1gupC_ 14 c3p0tB_ 15 c5in3A_ 16 d1emsa1 17 d1z84a2 18 d1guqa2 19 d1fita_ 20 d2oika1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99