1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	A	G	P	A	I	E	V	A	V	A	F	V	W	L	G	M	V	V	A	I	S	F	L	E	A	P	L	K	F	R	A	A	G	V	T	L	Q	I	G	L	G	I	G	R	L	V	F	R	A	L	N	T	V	E	V	G	F	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	V	I	L	A	I	V	V	V	G	S	T	P	A	R	I	A	A	A	F	S	V	A	L	A	A	L	A	V	Q	L	I	A	V	R	P	R	L	T	R	R	S	N	Q	V	L	A	G	L	Q	A	P	R	S	R	G	H	H	I	Y
Secondary structure
SS confidence
Disorder												?																																				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.
Sequence		V	G	L	E	I	V	K	V	V	A	L	L	V	A	G	I	L	L	L	N	G
Secondary structure
SS confidence
Disorder																				?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 85%) Beta strand ( 0%) TM helix ( 58%) (View membrane topology prediction)

Rank Aligned region

PDB 1vc2 chain A domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 30.0% Identity: 78% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 2g82 chain A domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 26.3% Identity: 78% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 5kzo chain A Region: 109 - 138 Aligned: 30 Modelled: 30 Confidence: 25.5% Identity: 23% PDB header:transcription Chain: A: PDB Molecule:neurogenic locus notch homolog protein 1; PDBTitle: notch1 transmembrane and associated juxtamembrane segment Phyre2 PDB 2mux chain A Region: 16 - 37 Aligned: 22 Modelled: 22 Confidence: 25.4% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:ubiquitin carboxyl-terminal hydrolase 25; PDBTitle: sumo2 non-covalently interacts with usp25 and downregulates its2 activity Phyre2 PDB 1k3t chain A domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 24.6% Identity: 78% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1gga chain A domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 24.1% Identity: 78% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1u8f chain O domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 22.1% Identity: 78% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1i32 chain A domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 21.8% Identity: 67% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 3gpd chain G domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 21.0% Identity: 78% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1j0x chain O domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 20.8% Identity: 78% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1hdg chain O domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 20.2% Identity: 67% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 2b4r chain O domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 19.9% Identity: 89% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1rm4 chain A domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 19.7% Identity: 44% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1obf chain O domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 19.5% Identity: 56% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1gad chain O domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 19.5% Identity: 78% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 2pkq chain O domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 18.2% Identity: 44% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1q90 chain L Region: 36 - 50 Aligned: 15 Modelled: 15 Confidence: 16.6% Identity: 53% PDB header:photosynthesis Chain: L: PDB Molecule:cytochrome b6f complex subunit petl; PDBTitle: structure of the cytochrome b6f (plastohydroquinone : plastocyanin2 oxidoreductase) from chlamydomonas reinhardtii Phyre2 PDB 1q90 chain L Region: 36 - 50 Aligned: 15 Modelled: 15 Confidence: 16.6% Identity: 53% Fold: Single transmembrane helix Superfamily: PetL subunit of the cytochrome b6f complex Family: PetL subunit of the cytochrome b6f complex Phyre2 PDB 3cmc chain O domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 15.9% Identity: 78% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 1dss chain G domain 1 Region: 44 - 52 Aligned: 9 Modelled: 9 Confidence: 15.1% Identity: 78% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 1 d1vc2a1 2 d2g82a1 3 c5kzoA_ 4 c2muxA_ 5 d1k3ta1 6 d1ggaa1 7 d1u8fo1 8 d1i32a1 9 d3gpdg1 10 d1j0xo1 11 d1hdgo1 12 d2b4ro1 13 d1rm4a1 14 d1obfo1 15 d1gado1 16 d2pkqo1 17 c1q90L_ 18 d1q90l_ 19 d3cmco1 20 d1dssg1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46