1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	V	E	A	L	L	Q	S	I	P	P	L	M	V	Y	L	V	V	G	A	V	V	G	I	E	S	L	G	I	P	L	P	G	E	I	V	L	V	S	A	A	V	L	S	S	H	P	E	L	A	V	N	P	I	G	V	G	G	A
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	V	I	G	A	V	V	G	D	S	I	G	Y	S	I	G	R	R	F	G	L	P	L	F	D	R	L	G	R	R	F	P	K	H	F	G	P	G	H	V	A	L	A	E	R	L	F	N	R	W	G	V	R	A	V	F	L	G	R	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	A	L	L	R	I	F	A	G	P	L	A	G	A	L	K	M	P	Y	P	R	F	L	A	A	N	V	T	G	G	I	C	W	A	G	G	T	T	A	L	V	Y	F	A	G	M	A	A	Q	H	W	L	E	R	F	S	W	I	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.
Sequence		V	I	A	V	I	A	G	I	T	A	A	I	L	L	R	E	R	T	S	R	A	I	A	E	L	E	A	E	H	C	R	K	A	G	T	T	A	A
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 82%) Beta strand ( 0%) TM helix ( 56%) (View membrane topology prediction)

Rank Aligned region

PDB 4j05 chain A Region: 112 - 213 Aligned: 102 Modelled: 102 Confidence: 70.2% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 4huq chain S Region: 33 - 72 Aligned: 33 Modelled: 40 Confidence: 64.7% Identity: 15% PDB header:hydrolase Chain: S: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a transporter Phyre2 PDB 5a1s chain B Region: 12 - 217 Aligned: 190 Modelled: 192 Confidence: 47.4% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:citrate-sodium symporter; PDBTitle: crystal structure of the sodium-dependent citrate symporter secits2 form salmonella enterica. Phyre2 PDB 3qnq chain D Region: 108 - 214 Aligned: 107 Modelled: 107 Confidence: 31.8% Identity: 5% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 6hwh chain X Region: 135 - 214 Aligned: 79 Modelled: 80 Confidence: 27.0% Identity: 9% PDB header:electron transport Chain: X: PDB Molecule:cytochrome c oxidase polypeptide 4; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 2knc chain A Region: 175 - 212 Aligned: 38 Modelled: 38 Confidence: 26.9% Identity: 5% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 4dji chain A Region: 136 - 217 Aligned: 82 Modelled: 82 Confidence: 26.7% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter; PDBTitle: structure of glutamate-gaba antiporter gadc Phyre2 PDB 4z7f chain D Region: 33 - 164 Aligned: 114 Modelled: 132 Confidence: 26.1% Identity: 11% PDB header:transport protein Chain: D: PDB Molecule:folate ecf transporter; PDBTitle: crystal structure of folt bound with folic acid Phyre2 PDB 2bbj chain B Region: 97 - 200 Aligned: 70 Modelled: 70 Confidence: 24.7% Identity: 21% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 2n28 chain A Region: 178 - 216 Aligned: 39 Modelled: 39 Confidence: 21.3% Identity: 26% PDB header:viral protein Chain: A: PDB Molecule:protein vpu; PDBTitle: solid-state nmr structure of vpu Phyre2 PDB 2w8a chain C Region: 150 - 216 Aligned: 67 Modelled: 67 Confidence: 14.2% Identity: 18% PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate Phyre2 PDB 5d7t chain C Region: 14 - 171 Aligned: 142 Modelled: 158 Confidence: 13.7% Identity: 16% PDB header:transport protein Chain: C: PDB Molecule:s-component for folate; PDBTitle: folate ecf transporter: apo state Phyre2 PDB 1fft chain B domain 2 Region: 165 - 215 Aligned: 51 Modelled: 51 Confidence: 12.9% Identity: 8% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 6jny chain A Region: 95 - 114 Aligned: 20 Modelled: 20 Confidence: 12.8% Identity: 10% PDB header:transcription Chain: A: PDB Molecule:antiterminator q protein; PDBTitle: crystal structure of bacteriophage 21 q protein Phyre2 PDB 6iu3 chain A Region: 35 - 202 Aligned: 161 Modelled: 168 Confidence: 12.6% Identity: 15% PDB header:metal transport Chain: A: PDB Molecule:vit1; PDBTitle: crystal structure of iron transporter vit1 with zinc ions Phyre2 PDB 5u1d chain B Region: 13 - 211 Aligned: 179 Modelled: 181 Confidence: 10.0% Identity: 9% PDB header:transport protein Chain: B: PDB Molecule:antigen peptide transporter 2; PDBTitle: cryo-em structure of the human tap atp-binding cassette transporter Phyre2 PDB 4hzu chain S Region: 33 - 201 Aligned: 122 Modelled: 129 Confidence: 7.2% Identity: 10% PDB header:hydrolase, transport protein Chain: S: PDB Molecule:predicted membrane protein; PDBTitle: structure of a bacterial energy-coupling factor transporter Phyre2 PDB 4ain chain B Region: 150 - 211 Aligned: 62 Modelled: 62 Confidence: 7.2% Identity: 19% PDB header:membrane protein Chain: B: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of betp with asymmetric protomers. Phyre2 PDB 3qf4 chain A Region: 13 - 211 Aligned: 179 Modelled: 181 Confidence: 7.0% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:abc transporter, atp-binding protein; PDBTitle: crystal structure of a heterodimeric abc transporter in its inward-2 facing conformation Phyre2 PDB 2mom chain B Region: 46 - 78 Aligned: 33 Modelled: 33 Confidence: 6.2% Identity: 24% PDB header:membrane protein Chain: B: PDB Molecule:lysosome-associated membrane glycoprotein 2; PDBTitle: structural insights of tm domain of lamp-2a in dpc micelles Phyre2 1 c4j05A_ 2 c4huqS_ 3 c5a1sB_ 4 c3qnqD_ 5 c6hwhX_ 6 c2kncA_ 7 c4djiA_ 8 c4z7fD_ 9 c2bbjB_ 10 c2n28A_ 11 c2w8aC_ 12 c5d7tC_ 13 d1fftb2 14 c6jnyA_ 15 c6iu3A_ 16 c5u1dB_ 17 c4hzuS_ 18 c4ainB_ 19 c3qf4A_ 20 c2momB_ 21 22 23 24 25 26 27