1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	Y	G	A	L	V	T	A	A	D	S	I	R	T	G	L	G	A	S	L	L	A	G	F	R	P	R	T	G	A	P	S	T	A	T	I	L	R	S	A	L	W	P	A	A	V	L	S	V	L	H	R	S	I	V	L	T	T	N	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?								?	?	?	?	?		?				?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	I	T	D	D	F	K	P	V	Y	R	A	V	L	N	F	R	R	G	W	D	I	Y	N	E	H	F	D	Y	V	D	P	H	Y	L	Y	P	P	G	G	T	L	L	M	A	P	F	G	Y	L	P	F	A	P	S	R	Y	L	F	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	I	N	T	A	A	I	L	V	A	A	Y	L	L	L	R	M	F	N	F	T	L	T	S	V	A	A	P	A	L	I	L	A	M	F	A	T	E	T	V	T	N	T	L	V	F	T	N	I	N	G	C	I	L	L	L	E	V	L	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	R	W	L	L	D	G	R	A	S	R	Q	W	C	G	G	L	A	I	G	L	T	L	V	L	K	P	L	L	G	P	L	L	L	L	P	L	L	N	R	Q	W	R	A	L	V	A	A	V	V	V	P	V	V	V	N	V	A	A	L
Secondary structure
SS confidence
Disorder									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	L	V	S	D	P	M	S	F	F	T	R	T	L	P	Y	I	L	G	T	R	D	Y	F	N	S	S	I	L	G	N	G	V	Y	F	G	L	P	T	W	L	I	L	F	L	R	I	L	F	T	A	I	T	F	G	A	L	W	L	L
Secondary structure
SS confidence
Disorder																					?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Y	R	Y	Y	R	T	G	D	P	L	F	W	F	T	T	S	S	G	V	L	L	L	W	S	W	L	V	M	S	L	A	Q	G	Y	Y	S	M	M	L	F	P	F	L	M	T	V	V	L	P	N	S	V	I	R	N	W	P	A	W	L
Secondary structure
SS confidence
Disorder																																																					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	V	Y	G	F	M	T	L	D	R	W	L	L	F	N	W	M	R	W	G	R	A	L	E	Y	L	K	I	T	Y	G	W	S	L	L	L	I	V	T	F	T	V	L	Y	F	R	Y	L	D	A	K	A	D	N	R	L	D	G	G	I
Secondary structure
SS confidence
Disorder												?	?	?	?	?			?																																?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.
Sequence		D	P	A	W	L	T	P	E	R	E	G	Q	R
Secondary structure
SS confidence
Disorder		?		?		?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 71%) Beta strand ( 0%) TM helix ( 50%) (View membrane topology prediction)

Rank Aligned region

PDB 5f15 chain A Region: 38 - 415 Aligned: 367 Modelled: 378 Confidence: 99.1% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:4-amino-4-deoxy-l-arabinose (l-ara4n) transferase; PDBTitle: crystal structure of arnt from cupriavidus metallidurans bound to2 undecaprenyl phosphate Phyre2 PDB 6p25 chain A Region: 39 - 270 Aligned: 222 Modelled: 232 Confidence: 99.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 1; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor and a peptide acceptor Phyre2 PDB 6p2r chain B Region: 39 - 272 Aligned: 224 Modelled: 234 Confidence: 98.8% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 2; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor Phyre2 PDB 3rce chain A Region: 63 - 242 Aligned: 172 Modelled: 180 Confidence: 94.9% Identity: 15% PDB header:transferase/peptide Chain: A: PDB Molecule:oligosaccharide transferase to n-glycosylate proteins; PDBTitle: bacterial oligosaccharyltransferase pglb Phyre2 PDB 3waj chain A Region: 40 - 347 Aligned: 307 Modelled: 308 Confidence: 85.4% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:transmembrane oligosaccharyl transferase; PDBTitle: crystal structure of the archaeoglobus fulgidus2 oligosaccharyltransferase (o29867_arcfu) complex with zn and sulfate Phyre2 PDB 6ezn chain F Region: 36 - 244 Aligned: 208 Modelled: 209 Confidence: 84.9% Identity: 15% PDB header:membrane protein Chain: F: PDB Molecule:dolichyl-diphosphooligosaccharide--protein PDBTitle: cryo-em structure of the yeast oligosaccharyltransferase (ost) complex Phyre2 PDB 6nbx chain G Region: 393 - 432 Aligned: 40 Modelled: 40 Confidence: 35.8% Identity: 25% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase subunit j; PDBTitle: t.elongatus ndh (data-set 2) Phyre2 PDB 2lqt chain A Region: 404 - 432 Aligned: 29 Modelled: 29 Confidence: 22.0% Identity: 17% PDB header:unknown function Chain: A: PDB Molecule:coiled-coil-helix-coiled-coil-helix domain-containing PDBTitle: solution structure of chchd7 Phyre2 PDB 5z7l chain D Region: 4 - 18 Aligned: 15 Modelled: 15 Confidence: 14.0% Identity: 47% PDB header:signaling protein Chain: D: PDB Molecule:5-azacytidine-induced protein 2; PDBTitle: crystal structure of ndp52 skich region in complex with nap1 Phyre2 PDB 1jrj chain A Region: 59 - 78 Aligned: 20 Modelled: 20 Confidence: 11.8% Identity: 30% PDB header:hormone/growth factor Chain: A: PDB Molecule:exendin-4; PDBTitle: solution structure of exendin-4 in 30-vol% trifluoroethanol Phyre2 PDB 1g12 chain A Region: 48 - 76 Aligned: 28 Modelled: 29 Confidence: 10.5% Identity: 25% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Fungal zinc peptidase Phyre2 PDB 5sxp chain G Region: 412 - 432 Aligned: 21 Modelled: 20 Confidence: 10.5% Identity: 24% PDB header:signaling protein/ligase Chain: G: PDB Molecule:e3 ubiquitin-protein ligase itchy homolog; PDBTitle: structural basis for the interaction between itch prr and beta-pix Phyre2 PDB 5sxp chain F Region: 414 - 431 Aligned: 18 Modelled: 18 Confidence: 10.3% Identity: 28% PDB header:signaling protein/ligase Chain: F: PDB Molecule:e3 ubiquitin-protein ligase itchy homolog; PDBTitle: structural basis for the interaction between itch prr and beta-pix Phyre2 PDB 2au5 chain A domain 1 Region: 55 - 92 Aligned: 36 Modelled: 38 Confidence: 9.7% Identity: 19% Fold: EF2947-like Superfamily: EF2947-like Family: EF2947-like Phyre2 PDB 2l64 chain A Region: 59 - 78 Aligned: 20 Modelled: 20 Confidence: 9.4% Identity: 20% PDB header:hormone Chain: A: PDB Molecule:glucagon-like peptide 2; PDBTitle: nmr solution structure of glp-2 in dhpc micelles Phyre2 PDB 2mgy chain A Region: 218 - 347 Aligned: 114 Modelled: 114 Confidence: 9.3% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:translocator protein; PDBTitle: solution structure of the mitochondrial translocator protein (tspo) in2 complex with its high-affinity ligand pk11195 Phyre2 PDB 2khs chain B Region: 94 - 98 Aligned: 5 Modelled: 5 Confidence: 8.0% Identity: 60% PDB header:hydrolase Chain: B: PDB Molecule:nuclease; PDBTitle: solution structure of snase121:snase(111-143) complex Phyre2 PDB 1d0r chain A Region: 59 - 78 Aligned: 20 Modelled: 20 Confidence: 7.4% Identity: 25% PDB header:hormone/growth factor Chain: A: PDB Molecule:glucagon-like peptide-1-(7-36)-amide; PDBTitle: solution structure of glucagon-like peptide-1-(7-36)-amide in2 trifluoroethanol/water Phyre2 PDB 2r6g chain F domain 1 Region: 101 - 170 Aligned: 70 Modelled: 70 Confidence: 7.3% Identity: 17% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 4mjk chain A Region: 88 - 103 Aligned: 16 Modelled: 16 Confidence: 7.0% Identity: 38% PDB header:protein binding Chain: A: PDB Molecule:crispr protein; PDBTitle: crystal structure of a crispr protein from archaeoglobus fulgidus Phyre2 1 c5f15A_ 2 c6p25A_ 3 c6p2rB_ 4 c3rceA_ 5 c3wajA_ 6 c6eznF_ 7 c6nbxG_ 8 c2lqtA_ 9 c5z7lD_ 10 c1jrjA_ 11 d1g12a_ 12 c5sxpG_ 13 c5sxpF_ 14 d2au5a1 15 c2l64A_ 16 c2mgyA_ 17 c2khsB_ 18 c1d0rA_ 19 d2r6gf1 20 c4mjkA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36