1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	T	S	A	G	D	D	A	E	R	S	D	E	E	E	R	R	L	T	S	A	E	P	A	L	F	R	E	A	V	A	A	M	N	A	V	T	V	R	P	E	I	E	L	G	P	I	R	P	P	Q	R	L	A	P	Y	S	Y	A	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?											?	?	?	?		?									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	A	E	I	K	H	P	E	L	D	V	I	P	E	R	S	E	G	D	A	F	G	R	L	I	M	L	Y	D	P	D	G	S	D	A	W	D	G	T	I	R	L	V	A	Y	V	Q	A	D	L	D	S	S	E	A	V	D	P	L	L
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?	?	?	?													?		?	?	?															?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	E	V	A	W	S	W	L	V	D	A	L	T	A	R	T	D	Q	V	R	A	L	G	G	T	V	T	A	T	T	S	V	R	Y	G	D	I	S	G	P	P	R	A	H	Q	L	E	L	R	A	S	W	T	A	T	T	P	D	L	G
Secondary structure
SS confidence
Disorder																	?																?		?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence		A	H	V	Q	A	F	C	D	V	L	E	H	A	A	G	L	P	P	A	G	V	T	D	L	G	S	R	S	R	A
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 35%) Alpha helix ( 22%) Beta strand ( 26%)

Rank Aligned region

PDB 1ziv chain A Region: 83 - 100 Aligned: 18 Modelled: 18 Confidence: 45.9% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:calpain 9; PDBTitle: catalytic domain of human calpain-9 Phyre2 PDB 1ziv chain A domain 1 Region: 83 - 100 Aligned: 18 Modelled: 18 Confidence: 45.9% Identity: 33% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Calpain large subunit, catalytic domain (domain II) Phyre2 PDB 6bdt chain C Region: 83 - 100 Aligned: 18 Modelled: 18 Confidence: 44.5% Identity: 33% PDB header:hydrolase Chain: C: PDB Molecule:calpain-3; PDBTitle: crystal structure of human calpain-3 protease core mutant-c129s Phyre2 PDB 1kfu chain L domain 3 Region: 83 - 100 Aligned: 18 Modelled: 18 Confidence: 43.4% Identity: 33% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Calpain large subunit, catalytic domain (domain II) Phyre2 PDB 3hlz chain A Region: 86 - 105 Aligned: 17 Modelled: 20 Confidence: 43.3% Identity: 41% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein bt_1490; PDBTitle: crystal structure of bt_1490 (np_810393.1) from bacteroides2 thetaiotaomicron vpi-5482 at 1.50 a resolution Phyre2 PDB 1mdw chain A Region: 83 - 100 Aligned: 18 Modelled: 18 Confidence: 38.3% Identity: 33% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Calpain large subunit, catalytic domain (domain II) Phyre2 PDB 2r9f chain A domain 1 Region: 83 - 100 Aligned: 18 Modelled: 18 Confidence: 37.7% Identity: 33% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Calpain large subunit, catalytic domain (domain II) Phyre2 PDB 1zcm chain A domain 1 Region: 83 - 100 Aligned: 18 Modelled: 18 Confidence: 36.2% Identity: 33% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Calpain large subunit, catalytic domain (domain II) Phyre2 PDB 1qxp chain A domain 4 Region: 83 - 100 Aligned: 18 Modelled: 18 Confidence: 33.1% Identity: 33% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Calpain large subunit, catalytic domain (domain II) Phyre2 PDB 1qxp chain B Region: 83 - 100 Aligned: 18 Modelled: 18 Confidence: 30.0% Identity: 33% PDB header:hydrolase chimera Chain: B: PDB Molecule:mu-like calpain; PDBTitle: crystal structure of a mu-like calpain Phyre2 PDB 1w96 chain A domain 1 Region: 57 - 123 Aligned: 58 Modelled: 67 Confidence: 24.9% Identity: 16% Fold: Barrel-sandwich hybrid Superfamily: Rudiment single hybrid motif Family: BC C-terminal domain-like Phyre2 PDB 1ulz chain A domain 1 Region: 57 - 123 Aligned: 58 Modelled: 67 Confidence: 18.9% Identity: 19% Fold: Barrel-sandwich hybrid Superfamily: Rudiment single hybrid motif Family: BC C-terminal domain-like Phyre2 PDB 2p3p chain A domain 1 Region: 118 - 170 Aligned: 52 Modelled: 52 Confidence: 18.1% Identity: 21% Fold: PG1388-like Superfamily: PG1388-like Family: PG1388-like Phyre2 PDB 4a4k chain I Region: 79 - 103 Aligned: 25 Modelled: 25 Confidence: 17.8% Identity: 20% PDB header:hydrolase Chain: I: PDB Molecule:antiviral helicase ski2; PDBTitle: crystal structure of the s. cerevisiae ski2 insertion domain Phyre2 PDB 2j9g chain A domain 1 Region: 57 - 123 Aligned: 57 Modelled: 67 Confidence: 15.7% Identity: 16% Fold: Barrel-sandwich hybrid Superfamily: Rudiment single hybrid motif Family: BC C-terminal domain-like Phyre2 PDB 4rcn chain A Region: 51 - 123 Aligned: 66 Modelled: 73 Confidence: 14.7% Identity: 23% PDB header:ligase Chain: A: PDB Molecule:long-chain acyl-coa carboxylase; PDBTitle: structure and function of a single-chain, multi-domain long-chain2 acyl-coa carboxylase Phyre2 PDB 1vko chain A Region: 173 - 199 Aligned: 27 Modelled: 27 Confidence: 13.8% Identity: 15% PDB header:isomerase Chain: A: PDB Molecule:inositol-3-phosphate synthase; PDBTitle: crystal structure of inositol-3-phosphate synthase (ce21227) from2 caenorhabditis elegans at 2.30 a resolution Phyre2 PDB 2ipq chain X domain 1 Region: 120 - 154 Aligned: 35 Modelled: 35 Confidence: 13.5% Identity: 29% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: STY4665 C-terminal domain-like Phyre2 PDB 1p1j chain A domain 1 Region: 173 - 207 Aligned: 35 Modelled: 35 Confidence: 12.6% Identity: 20% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Phyre2 PDB 5civ chain A Region: 172 - 199 Aligned: 26 Modelled: 28 Confidence: 11.7% Identity: 19% PDB header:unknown function Chain: A: PDB Molecule:sibling bacteriocin; PDBTitle: sibling lethal factor precursor - dfsb Phyre2 1 c1zivA_ 2 d1ziva1 3 c6bdtC_ 4 d1kful3 5 c3hlzA_ 6 d1mdwa_ 7 d2r9fa1 8 d1zcma1 9 d1qxpa4 10 c1qxpB_ 11 d1w96a1 12 d1ulza1 13 d2p3pa1 14 c4a4kI_ 15 d2j9ga1 16 c4rcnA_ 17 c1vkoA_ 18 d2ipqx1 19 d1p1ja1 20 c5civA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60