1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	V	N	I	D	P	T	A	P	T	F	A	T	Y	R	R	D	M	R	A	E	Q	M	A	E	D	Y	P	V	V	S	I	D	S	D	A	L	D	A	A	R	M	L	A	E	H	R	L	P	G	L	L	V	T	A	G	A	G	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	Y	A	V	L	P	A	S	Q	V	V	R	F	I	V	P	R	Y	V	Q	D	D	P	L	L	A	G	V	L	N	E	S	T	A	D	R	C	A	E	R	L	S	G	K	K	V	R	D	V	L	P	D	H	L	V	E	V	P	P	A
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?	?	?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.
Sequence		N	A	D	D	T	I	I	E	V	A	A	V	M	A	R	L	R	S	P	L	L	A	V	V	K	D	G	S	L	L	G	V	V	T	A	S	R	L	L	A	A	A	L	K	T
Secondary structure
SS confidence
Disorder																																													?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 38%) Beta strand ( 24%)

Rank Aligned region

PDB 4noc chain A Region: 24 - 164 Aligned: 139 Modelled: 140 Confidence: 100.0% Identity: 53% PDB header:signaling protein Chain: A: PDB Molecule:putative signal transduction protein with cbs domains; PDBTitle: the crystal structure of a cbs domain-containing protein of unknown2 function from kribbella flavida dsm 17836. Phyre2 PDB 2d4z chain A domain 3 Region: 13 - 162 Aligned: 150 Modelled: 150 Confidence: 99.9% Identity: 13% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 6coz chain B Region: 7 - 162 Aligned: 151 Modelled: 156 Confidence: 99.9% Identity: 14% PDB header:transport protein Chain: B: PDB Molecule:chloride channel protein 1; PDBTitle: human clc-1 chloride ion channel, c-terminal cytosolic domain Phyre2 PDB 2d4z chain B Region: 13 - 162 Aligned: 150 Modelled: 150 Confidence: 99.9% Identity: 14% PDB header:transport protein Chain: B: PDB Molecule:chloride channel protein; PDBTitle: crystal structure of the cytoplasmic domain of the chloride channel2 clc-0 Phyre2 PDB 2j9l chain A domain 1 Region: 17 - 164 Aligned: 148 Modelled: 148 Confidence: 99.9% Identity: 11% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 4esy chain B Region: 11 - 164 Aligned: 150 Modelled: 154 Confidence: 99.9% Identity: 19% PDB header:membrane protein Chain: B: PDB Molecule:cbs domain containing membrane protein; PDBTitle: crystal structure of the cbs domain of cbs domain containing membrane2 protein from sphaerobacter thermophilus Phyre2 PDB 3fwr chain B Region: 17 - 164 Aligned: 126 Modelled: 126 Confidence: 99.9% Identity: 13% PDB header:transcription Chain: B: PDB Molecule:yqzb protein; PDBTitle: crystal structure of the cbs domains from the bacillus subtilis ccpn2 repressor complexed with adp Phyre2 PDB 4l3v chain B Region: 7 - 164 Aligned: 133 Modelled: 137 Confidence: 99.9% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:cystathionine beta-synthase; PDBTitle: crystal structure of delta516-525 human cystathionine beta-synthase Phyre2 PDB 2qh1 chain B Region: 11 - 164 Aligned: 131 Modelled: 131 Confidence: 99.9% Identity: 24% PDB header:unknown function Chain: B: PDB Molecule:hypothetical protein ta0289; PDBTitle: structure of ta289, a cbs-rubredoxin-like protein, in its fe+2-bound2 state Phyre2 PDB 2oox chain E domain 1 Region: 10 - 164 Aligned: 150 Modelled: 155 Confidence: 99.9% Identity: 13% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 4o9k chain B Region: 19 - 163 Aligned: 121 Modelled: 121 Confidence: 99.9% Identity: 21% PDB header:isomerase Chain: B: PDB Molecule:arabinose 5-phosphate isomerase; PDBTitle: crystal structure of the cbs pair of a putative d-arabinose 5-2 phosphate isomerase from methylococcus capsulatus in complex with3 cmp-kdo Phyre2 PDB 3ddj chain A domain 1 Region: 19 - 164 Aligned: 128 Modelled: 131 Confidence: 99.9% Identity: 18% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 2yzi chain A domain 1 Region: 20 - 164 Aligned: 121 Modelled: 121 Confidence: 99.9% Identity: 20% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 5tr1 chain A Region: 2 - 164 Aligned: 137 Modelled: 137 Confidence: 99.9% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:chloride channel protein; PDBTitle: cryo-electron microscopy structure of a bovine clc-k chloride channel,2 alternate (class 2) conformation Phyre2 PDB 2v8q chain E domain 2 Region: 12 - 163 Aligned: 143 Modelled: 152 Confidence: 99.9% Identity: 13% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 6qvc chain B Region: 1 - 162 Aligned: 135 Modelled: 135 Confidence: 99.9% Identity: 18% PDB header:membrane protein Chain: B: PDB Molecule:chloride channel protein 1; PDBTitle: cryoem structure of the human clc-1 chloride channel, cbs state 1 Phyre2 PDB 2v8q chain E Region: 24 - 165 Aligned: 122 Modelled: 122 Confidence: 99.9% Identity: 18% PDB header:transferase Chain: E: PDB Molecule:5'-amp-activated protein kinase subunit gamma-1; PDBTitle: crystal structure of the regulatory fragment of mammalian2 ampk in complexes with amp Phyre2 PDB 1o50 chain A domain 3 Region: 19 - 164 Aligned: 129 Modelled: 142 Confidence: 99.9% Identity: 17% Fold: CBS-domain pair Superfamily: CBS-domain pair Family: CBS-domain pair Phyre2 PDB 2qlv chain F Region: 24 - 163 Aligned: 120 Modelled: 120 Confidence: 99.9% Identity: 21% PDB header:transferase/protein binding Chain: F: PDB Molecule:nuclear protein snf4; PDBTitle: crystal structure of the heterotrimer core of the s. cerevisiae ampk2 homolog snf1 Phyre2 PDB 6h1w chain A Region: 20 - 164 Aligned: 120 Modelled: 120 Confidence: 99.9% Identity: 13% PDB header:unknown function Chain: A: PDB Molecule:mj1004; PDBTitle: crystal structure of protein mj1004 from mathanocaldococcus jannaschii Phyre2 1 c4nocA_ 2 d2d4za3 3 c6cozB_ 4 c2d4zB_ 5 d2j9la1 6 c4esyB_ 7 c3fwrB_ 8 c4l3vB_ 9 c2qh1B_ 10 d2ooxe1 11 c4o9kB_ 12 d3ddja1 13 d2yzia1 14 c5tr1A_ 15 d2v8qe2 16 c6qvcB_ 17 c2v8qE_ 18 d1o50a3 19 c2qlvF_ 20 c6h1wA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150