1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	V	V	A	V	T	I	F	V	A	A	Y	V	L	I	A	S	D	R	V	N	K	T	M	V	A	L	T	G	A	A	A	V	V	V	L	P	V	I	T	S	H	D	I	F	Y	S	H	D	T	G	I	D	W	D	V	I	F	L
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	V	G	M	M	I	I	V	G	V	L	R	Q	T	G	V	F	E	Y	T	A	I	W	A	A	K	R	A	R	G	S	P	L	R	I	M	I	L	L	V	L	V	S	A	L	A	S	A	L	L	D	N	V	T	T	V	L	L	I	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	V	T	L	L	V	C	D	R	L	N	I	N	T	T	S	F	L	M	A	E	V	F	A	S	N	I	G	G	A	A	T	L	V	G	D	P	P	N	I	I	V	A	S	R	A	G	L	T	F	N	D	F	M	L	H	L	T	P	L
Secondary structure
SS confidence
Disorder											?	?	?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	V	I	V	L	I	A	L	I	A	V	L	P	R	L	F	G	S	I	T	V	E	A	D	R	I	A	D	V	M	A	L	D	E	G	E	A	I	R	D	R	G	L	L	V	K	C	G	A	V	L	V	L	V	F	A	A	F	V	A
Secondary structure
SS confidence
Disorder																				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		H	P	V	L	H	I	Q	P	S	L	V	A	L	L	G	A	G	M	L	I	V	V	S	G	L	T	R	S	E	Y	L	S	S	V	E	W	D	T	L	L	F	F	A	G	L	F	I	M	V	G	A	L	V	K	T	G	V	V	N	D
Secondary structure
SS confidence
Disorder						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	A	R	A	A	T	Q	L	T	G	G	N	I	V	A	T	A	F	L	I	L	G	V	S	A	P	I	S	G	I	I	D	N	I	P	Y	V	A	T	M	T	P	L	V	A	E	L	V	A	V	M	G	G	Q	P	S	T	D	T	P
Secondary structure
SS confidence
Disorder											?																																								?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		W	W	A	L	A	L	G	A	D	F	G	G	N	L	T	A	I	G	A	S	A	N	V	V	M	L	G	I	A	R	R	A	G	A	P	I	S	F	W	E	F	T	R	K	G	A	V	V	T	A	V	S	I	A	L	A	A	I	Y	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.
Sequence		W	L	R	Y	F	V	L	L	H
Secondary structure
SS confidence
Disorder								?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 79%) Beta strand ( 0%) TM helix ( 64%) (View membrane topology prediction)

Rank Aligned region

PDB 4f35 chain C Region: 2 - 424 Aligned: 396 Modelled: 408 Confidence: 100.0% Identity: 22% PDB header:transport protein Chain: C: PDB Molecule:transporter, nadc family; PDBTitle: crystal structure of a bacterial dicarboxylate/sodium symporter Phyre2 PDB 4r1i chain B Region: 54 - 427 Aligned: 367 Modelled: 374 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: B: PDB Molecule:aminobenzoyl-glutamate transporter; PDBTitle: structure and function of neisseria gonorrhoeae mtrf illuminates a2 class of antimetabolite efflux pumps Phyre2 PDB 4r0c chain B Region: 42 - 426 Aligned: 369 Modelled: 385 Confidence: 99.9% Identity: 14% PDB header:membrane protein Chain: B: PDB Molecule:abgt putative transporter family; PDBTitle: crystal structure of the alcanivorax borkumensis ydah transporter2 reveals an unusual topology Phyre2 PDB 5a1s chain B Region: 1 - 331 Aligned: 302 Modelled: 315 Confidence: 93.4% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:citrate-sodium symporter; PDBTitle: crystal structure of the sodium-dependent citrate symporter secits2 form salmonella enterica. Phyre2 PDB 3qnq chain D Region: 178 - 215 Aligned: 38 Modelled: 38 Confidence: 54.8% Identity: 8% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 4kpp chain A Region: 181 - 418 Aligned: 166 Modelled: 179 Confidence: 25.0% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of h+/ca2+ exchanger cax Phyre2 PDB 2b6p chain A Region: 108 - 221 Aligned: 114 Modelled: 114 Confidence: 15.9% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:lens fiber major intrinsic protein; PDBTitle: x-ray structure of lens aquaporin-0 (aqp0) (lens mip) in an open pore2 state Phyre2 PDB 3mk7 chain F Region: 173 - 240 Aligned: 68 Modelled: 68 Confidence: 8.4% Identity: 9% PDB header:oxidoreductase Chain: F: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit p; PDBTitle: the structure of cbb3 cytochrome oxidase Phyre2 PDB 6nbx chain G Region: 166 - 223 Aligned: 58 Modelled: 58 Confidence: 8.2% Identity: 21% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase subunit j; PDBTitle: t.elongatus ndh (data-set 2) Phyre2 PDB 2bbj chain B Region: 158 - 200 Aligned: 40 Modelled: 43 Confidence: 7.0% Identity: 20% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 1fft chain B domain 2 Region: 172 - 238 Aligned: 67 Modelled: 67 Confidence: 6.9% Identity: 12% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 1y5i chain C domain 1 Region: 169 - 297 Aligned: 129 Modelled: 129 Confidence: 6.6% Identity: 9% Fold: Heme-binding four-helical bundle Superfamily: Respiratory nitrate reductase 1 gamma chain Family: Respiratory nitrate reductase 1 gamma chain Phyre2 PDB 4dji chain A Region: 174 - 224 Aligned: 51 Modelled: 51 Confidence: 6.4% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter; PDBTitle: structure of glutamate-gaba antiporter gadc Phyre2 PDB 5lev chain A Region: 174 - 292 Aligned: 117 Modelled: 119 Confidence: 5.6% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:udp-n-acetylglucosamine--dolichyl-phosphate n- PDBTitle: crystal structure of human udp-n-acetylglucosamine-dolichyl-phosphate2 n-acetylglucosaminephosphotransferase (dpagt1) (v264g mutant) Phyre2 1 c4f35C_ 2 c4r1iB_ 3 c4r0cB_ 4 c5a1sB_ 5 c3qnqD_ 6 c4kppA_ 7 c2b6pA_ 8 c3mk7F_ 9 c6nbxG_ 10 c2bbjB_ 11 d1fftb2 12 d1y5ic1 13 c4djiA_ 14 c5levA_