1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	I	I	A	I	T	V	F	V	A	G	Y	A	L	I	A	S	D	R	V	S	K	T	R	V	A	L	T	C	A	A	I	M	V	G	A	G	I	V	G	S	D	D	V	F	Y	S	H	E	A	G	I	D	W	D	V	I	F	L
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	G	M	M	I	I	V	S	V	L	R	H	T	G	V	F	E	Y	V	A	I	W	A	V	K	R	A	N	A	A	P	L	R	I	M	I	L	L	V	L	V	T	A	L	G	S	A	L	L	D	N	V	T	T	V	L	L	I	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	V	T	L	L	V	C	D	R	L	G	V	N	S	T	P	F	L	V	A	E	V	F	A	S	N	V	G	G	A	A	T	L	V	G	D	P	P	N	I	I	I	A	S	R	A	G	L	T	F	N	D	F	L	I	H	M	A	P	A
Secondary structure
SS confidence
Disorder											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	L	V	V	M	I	A	L	I	G	L	L	P	W	L	L	G	S	V	T	A	E	P	D	R	V	A	D	V	L	S	L	N	E	R	E	A	I	H	D	R	G	L	L	I	K	C	G	V	V	L	V	L	V	F	A	A	F	I	A
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		H	P	V	L	H	I	Q	P	S	L	V	A	L	L	G	A	G	V	L	V	R	F	S	G	L	E	R	S	D	Y	L	S	S	V	E	W	D	T	L	L	F	F	A	G	L	F	V	M	V	G	A	L	V	K	T	G	V	V	E	Q
Secondary structure
SS confidence
Disorder																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	A	R	A	A	T	E	L	T	G	G	N	E	L	L	T	V	G	L	I	L	G	I	S	A	P	V	S	G	I	I	D	N	I	P	Y	V	A	T	M	T	P	I	V	T	E	L	V	A	A	M	P	G	H	V	H	P	D	T	F
Secondary structure
SS confidence
Disorder									?	?	?	?																																						?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		W	W	A	L	A	L	S	A	D	F	G	G	N	L	T	A	V	A	A	S	A	N	V	V	M	L	G	I	A	R	R	S	G	T	P	I	S	F	W	K	F	T	R	K	G	A	V	V	T	A	V	S	L	V	L	S	A	V	Y	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		W	L	R	Y	F	V	F	G
Secondary structure
SS confidence
Disorder							?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 79%) Beta strand ( 0%) TM helix ( 63%) (View membrane topology prediction)

Rank Aligned region

PDB 4f35 chain C Region: 2 - 424 Aligned: 396 Modelled: 408 Confidence: 100.0% Identity: 21% PDB header:transport protein Chain: C: PDB Molecule:transporter, nadc family; PDBTitle: crystal structure of a bacterial dicarboxylate/sodium symporter Phyre2 PDB 4r1i chain B Region: 54 - 428 Aligned: 368 Modelled: 375 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:aminobenzoyl-glutamate transporter; PDBTitle: structure and function of neisseria gonorrhoeae mtrf illuminates a2 class of antimetabolite efflux pumps Phyre2 PDB 4r0c chain B Region: 42 - 426 Aligned: 369 Modelled: 385 Confidence: 99.9% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:abgt putative transporter family; PDBTitle: crystal structure of the alcanivorax borkumensis ydah transporter2 reveals an unusual topology Phyre2 PDB 5a1s chain B Region: 4 - 411 Aligned: 352 Modelled: 371 Confidence: 86.5% Identity: 16% PDB header:transport protein Chain: B: PDB Molecule:citrate-sodium symporter; PDBTitle: crystal structure of the sodium-dependent citrate symporter secits2 form salmonella enterica. Phyre2 PDB 1y5i chain C domain 1 Region: 169 - 298 Aligned: 130 Modelled: 130 Confidence: 28.1% Identity: 10% Fold: Heme-binding four-helical bundle Superfamily: Respiratory nitrate reductase 1 gamma chain Family: Respiratory nitrate reductase 1 gamma chain Phyre2 PDB 3qnq chain D Region: 80 - 211 Aligned: 122 Modelled: 132 Confidence: 14.9% Identity: 6% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 2bbj chain B Region: 158 - 200 Aligned: 40 Modelled: 43 Confidence: 11.8% Identity: 28% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 4lep chain B Region: 63 - 228 Aligned: 166 Modelled: 166 Confidence: 8.7% Identity: 8% PDB header:membrane protein, tranport protein Chain: B: PDB Molecule:proton:oligopeptide symporter pot family; PDBTitle: structural insights into substrate recognition in proton dependent2 oligopeptide transporters Phyre2 PDB 2b6p chain A Region: 108 - 221 Aligned: 114 Modelled: 114 Confidence: 8.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:lens fiber major intrinsic protein; PDBTitle: x-ray structure of lens aquaporin-0 (aqp0) (lens mip) in an open pore2 state Phyre2 PDB 2gfp chain A Region: 64 - 241 Aligned: 178 Modelled: 178 Confidence: 8.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 3rfr chain I Region: 146 - 237 Aligned: 92 Modelled: 92 Confidence: 6.1% Identity: 12% PDB header:oxidoreductase Chain: I: PDB Molecule:pmob; PDBTitle: crystal structure of particulate methane monooxygenase (pmmo) from2 methylocystis sp. strain m Phyre2 PDB 2h8a chain A domain 1 Region: 174 - 294 Aligned: 117 Modelled: 121 Confidence: 5.2% Identity: 10% Fold: MAPEG domain-like Superfamily: MAPEG domain-like Family: MAPEG domain Phyre2 1 c4f35C_ 2 c4r1iB_ 3 c4r0cB_ 4 c5a1sB_ 5 d1y5ic1 6 c3qnqD_ 7 c2bbjB_ 8 c4lepB_ 9 c2b6pA_ 10 c2gfpA_ 11 c3rfrI_ 12 d2h8aa1