1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	T	T	L	A	I	V	R	L	D	P	G	L	P	L	P	S	R	A	H	D	G	D	A	G	V	D	L	Y	S	A	E	D	V	E	L	A	P	G	R	R	A	L	V	R	T	G	V	A	V	A	V	P	F	G	M	V	G	L
Secondary structure
SS confidence
Disorder		?	?	?															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	H	P	R	S	G	L	A	T	R	V	G	L	S	I	V	N	S	P	G	T	I	D	A	G	Y	R	G	E	I	K	V	A	L	I	N	L	D	P	A	A	P	I	V	V	H	R	G	D	R	I	A	Q	L	L	V	Q	R	V	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.
Sequence		L	V	E	L	V	E	V	S	S	F	D	E	A	G	L	A	S	T	S	R	G	D	G	G	H	G	S	S	G	G	H	A	S	L
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 0%) Beta strand ( 47%)

Rank Aligned region

PDB 1six chain A Region: 1 - 149 Aligned: 144 Modelled: 149 Confidence: 100.0% Identity: 92% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3zf6 chain A Region: 2 - 150 Aligned: 143 Modelled: 149 Confidence: 100.0% Identity: 38% PDB header:hydrolase Chain: A: PDB Molecule:dutpase; PDBTitle: phage dutpases control transfer of virulence genes by a proto-2 oncogenic g protein-like mechanism. (staphylococcus bacteriophage3 80alpha dutpase d81a d110c s168c mutant with dupnhpp). Phyre2 PDB 3ehw chain A Region: 4 - 151 Aligned: 140 Modelled: 148 Confidence: 100.0% Identity: 42% PDB header:hydrolase Chain: A: PDB Molecule:dutp pyrophosphatase; PDBTitle: human dutpase in complex with alpha,beta-imido-dutp and mg2+:2 visualization of the full-length c-termini in all monomers and3 suggestion for an additional metal ion binding site Phyre2 PDB 3so2 chain A Region: 5 - 149 Aligned: 137 Modelled: 145 Confidence: 100.0% Identity: 45% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: chlorella dutpase Phyre2 PDB 1sjn chain A Region: 2 - 132 Aligned: 131 Modelled: 131 Confidence: 100.0% Identity: 100% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3ehw chain A domain 1 Region: 4 - 146 Aligned: 135 Modelled: 143 Confidence: 100.0% Identity: 42% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 5y5p chain B Region: 2 - 148 Aligned: 145 Modelled: 147 Confidence: 100.0% Identity: 35% PDB header:viral protein Chain: B: PDB Molecule:wsv112; PDBTitle: crystal structure of the dutpase of white spot syndrome virus in2 complex with du,ppi and mg2+ Phyre2 PDB 3f4f chain B Region: 5 - 146 Aligned: 134 Modelled: 142 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: B: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of dut1p, a dutpase from saccharomyces cerevisiae Phyre2 PDB 1f7r chain A Region: 10 - 151 Aligned: 131 Modelled: 142 Confidence: 100.0% Identity: 35% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 5vjy chain C Region: 1 - 132 Aligned: 129 Modelled: 132 Confidence: 100.0% Identity: 40% PDB header:hydrolase Chain: C: PDB Molecule:dutp pyrophosphatase; PDBTitle: crystal structure of dutp pyrophosphatase protein, from naegleria2 fowleri Phyre2 PDB 1euw chain A Region: 1 - 130 Aligned: 129 Modelled: 130 Confidence: 100.0% Identity: 33% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3ca9 chain A Region: 1 - 129 Aligned: 126 Modelled: 129 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase Phyre2 PDB 1rnj chain A Region: 1 - 131 Aligned: 130 Modelled: 131 Confidence: 100.0% Identity: 32% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3c3i chain A Region: 3 - 132 Aligned: 127 Modelled: 130 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase Phyre2 PDB 3tqz chain A Region: 4 - 131 Aligned: 127 Modelled: 128 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)2 from coxiella burnetii Phyre2 PDB 3mbq chain C Region: 4 - 145 Aligned: 131 Modelled: 142 Confidence: 100.0% Identity: 47% PDB header:hydrolase Chain: C: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase2 from brucella melitensis, orthorhombic crystal form Phyre2 PDB 3lqw chain A Region: 3 - 132 Aligned: 127 Modelled: 130 Confidence: 100.0% Identity: 38% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate2 nucleotidohydrolase from entamoeba histolytica Phyre2 PDB 6mai chain A Region: 4 - 132 Aligned: 128 Modelled: 129 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5'-triphosphate nucleotidohydrolase2 from legionella pneumophila philadelphia 1 Phyre2 PDB 1q5u chain Z Region: 4 - 131 Aligned: 125 Modelled: 128 Confidence: 100.0% Identity: 40% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 2p9o chain B Region: 5 - 129 Aligned: 122 Modelled: 125 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: B: PDB Molecule:dutp pyrophosphatase-like protein; PDBTitle: structure of dutpase from arabidopsis thaliana Phyre2 1 d1sixa_ 2 c3zf6A_ 3 c3ehwA_ 4 c3so2A_ 5 d1sjna_ 6 d3ehwa1 7 c5y5pB_ 8 c3f4fB_ 9 d1f7ra_ 10 c5vjyC_ 11 d1euwa_ 12 c3ca9A_ 13 d1rnja_ 14 c3c3iA_ 15 c3tqzA_ 16 c3mbqC_ 17 c3lqwA_ 18 c6maiA_ 19 d1q5uz_ 20 c2p9oB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79