1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	R	P	D	N	E	P	A	R	L	R	S	V	A	E	N	L	A	A	E	A	A	A	F	V	R	G	R	R	A	E	V	F	G	I	S	R	A	G	D	G	D	G	A	V	R	A	K	S	S	P	T	D	P	V	T	V	V	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																									?								?	?	?	?	?	?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	D	T	E	R	L	L	R	D	R	L	A	Q	L	R	P	G	D	P	I	L	G	E	E	G	G	G	P	A	D	V	T	A	T	P	S	D	R	V	T	W	V	L	D	P	I	D	G	T	V	N	F	V	Y	G	I	P	A	Y	A
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	S	I	G	A	Q	V	G	G	I	T	V	A	G	A	V	A	D	V	A	A	R	T	V	Y	S	A	A	T	G	L	G	A	H	L	T	D	E	R	G	R	H	V	L	R	C	T	G	V	D	E	L	S	M	A	L	L	G	T	G
Secondary structure
SS confidence
Disorder																																															?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	G	Y	S	V	R	C	R	E	K	Q	A	E	L	L	A	H	V	V	P	L	V	R	D	V	R	R	I	G	S	A	A	L	D	L	C	M	V	A	A	G	R	L	D	A	Y	Y	E	H	G	V	Q	V	W	D	C	A	A	G	A
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290
Sequence		L	I	A	A	E	A	G	A	R	V	L	L	S	T	P	R	A	G	G	A	G	L	V	V	V	A	A	A	P	G	I	A	D	E	L	L	A	A	L	Q	R	F	N	G	L	E	P	I	P	D
Secondary structure
SS confidence
Disorder																		?	?																										?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 37%) Beta strand ( 23%) TM helix ( 11%) (View membrane topology prediction)

Rank Aligned region

PDB 2q74 chain B Region: 5 - 286 Aligned: 245 Modelled: 263 Confidence: 100.0% Identity: 98% PDB header:hydrolase Chain: B: PDB Molecule:inositol-1-monophosphatase; PDBTitle: mycobacterium tuberculosis suhb Phyre2 PDB 3ryd chain A Region: 5 - 288 Aligned: 258 Modelled: 284 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:inositol monophosphatase family protein; PDBTitle: crystal strucutre of ca bound impase family protein from2 staphylococcus aureus Phyre2 PDB 2hhm chain A Region: 9 - 290 Aligned: 263 Modelled: 282 Confidence: 100.0% Identity: 30% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 2qfl chain A Region: 8 - 282 Aligned: 258 Modelled: 275 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:inositol-1-monophosphatase; PDBTitle: structure of suhb: inositol monophosphatase and extragenic2 suppressor from e. coli Phyre2 PDB 3qmf chain A Region: 7 - 286 Aligned: 248 Modelled: 280 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:inositol monophosphatase family protein; PDBTitle: crystal strucuture of an inositol monophosphatase family protein2 (sas2203) from staphylococcus aureus mssa476 Phyre2 PDB 3t0j chain B Region: 10 - 281 Aligned: 247 Modelled: 256 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: B: PDB Molecule:inositol monophosphatase family protein; PDBTitle: crystal structure of inositol monophosphatase - ii from staphylococcus2 aureus mssa476 Phyre2 PDB 5zon chain A Region: 11 - 279 Aligned: 252 Modelled: 269 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:histidinol-phosphatase; PDBTitle: histidinol phosphate phosphatase from mycobacterium tuberculosis Phyre2 PDB 4n81 chain A Region: 6 - 280 Aligned: 248 Modelled: 275 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:inositol monophosphatase; PDBTitle: another flexible region at the active site of an inositol2 monophosphatase from zymomonas mobilis Phyre2 PDB 2czh chain B Region: 9 - 281 Aligned: 239 Modelled: 251 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: B: PDB Molecule:inositol monophosphatase 2; PDBTitle: crystal structure of human myo-inositol monophosphatase 22 (impa2) with phosphate ion (orthorhombic form) Phyre2 PDB 5eq9 chain A Region: 7 - 280 Aligned: 243 Modelled: 253 Confidence: 100.0% Identity: 23% PDB header:biosynthetic protein Chain: A: PDB Molecule:inositol monophosphatase; PDBTitle: crystal structure of medicago truncatula histidinol-phosphate2 phosphatase (mthpp) in complex with l-histidinol phosphate and mg2+ Phyre2 PDB 3luz chain A Region: 10 - 281 Aligned: 236 Modelled: 251 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:extragenic suppressor protein suhb; PDBTitle: crystal structure of extragenic suppressor protein suhb from2 bartonella henselae, via combined iodide sad molecular replacement Phyre2 PDB 2p3n chain B Region: 11 - 282 Aligned: 246 Modelled: 257 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:inositol-1-monophosphatase; PDBTitle: thermotoga maritima impase tm1415 Phyre2 PDB 2fvz chain B Region: 9 - 279 Aligned: 238 Modelled: 248 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: B: PDB Molecule:inositol monophosphatase 2; PDBTitle: human inositol monophosphosphatase 2 Phyre2 PDB 5zhh chain B Region: 6 - 288 Aligned: 240 Modelled: 244 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: B: PDB Molecule:inositol-1-monophosphatase; PDBTitle: structure of inositol monophosphatase from anabaena (nostoc) sp. pcc2 7120 Phyre2 PDB 2pcr chain A Region: 7 - 282 Aligned: 233 Modelled: 239 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:inositol-1-monophosphatase; PDBTitle: crystal structure of myo-inositol-1(or 4)-monophosphatase (aq_1983)2 from aquifex aeolicus vf5 Phyre2 PDB 4gdg chain A Region: 7 - 282 Aligned: 264 Modelled: 276 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:3'(2'),5'-bisphosphate nucleotidase, putative; PDBTitle: structural and functional characterization of 3'(2'),5'-bisphosphate2 nucleotidase1 from entamoeba histolytica Phyre2 PDB 1g0h chain A Region: 11 - 279 Aligned: 241 Modelled: 269 Confidence: 100.0% Identity: 26% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 1ka1 chain A Region: 7 - 282 Aligned: 266 Modelled: 276 Confidence: 100.0% Identity: 24% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 PDB 5djj chain A Region: 5 - 283 Aligned: 244 Modelled: 245 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:3'-phosphoadenosine 5'-phosphate phosphatase; PDBTitle: structure of m. tuberculosis cysq, a pap phosphatase with po4 and 2mg2 bound Phyre2 PDB 1jp4 chain A Region: 5 - 281 Aligned: 262 Modelled: 276 Confidence: 100.0% Identity: 23% Fold: Carbohydrate phosphatase Superfamily: Carbohydrate phosphatase Family: Inositol monophosphatase/fructose-1,6-bisphosphatase-like Phyre2 1 c2q74B_ 2 c3rydA_ 3 d2hhma_ 4 c2qflA_ 5 c3qmfA_ 6 c3t0jB_ 7 c5zonA_ 8 c4n81A_ 9 c2czhB_ 10 c5eq9A_ 11 c3luzA_ 12 c2p3nB_ 13 c2fvzB_ 14 c5zhhB_ 15 c2pcrA_ 16 c4gdgA_ 17 d1g0ha_ 18 d1ka1a_ 19 c5djjA_ 20 d1jp4a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77