1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	K	Y	R	G	Q	F	E	L	N	R	P	A	T	L	I	A	A	L	P	A	I	L	G	F	V	P	E	K	S	L	V	L	V	S	L	A	A	G	E	L	G	S	V	M	R	A	D	L	C	D	E	L	A	D	R	V	G	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	A	E	L	V	A	A	A	N	P	A	A	A	I	A	V	I	V	D	A	N	G	A	Q	C	P	R	C	N	E	E	Y	R	Q	L	C	A	A	L	A	A	A	L	S	Q	R	D	I	V	L	W	A	A	H	V	V	D	R	V	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	G	G	R	W	H	C	V	D	G	C	G	C	S	G	V	I	D	D	P	S	A	S	P	L	A	M	A	A	V	L	D	G	R	Q	L	Y	P	R	R	S	D	L	Q	A	V	I	A	V	D	D	P	V	R	S	A	E	L	A	V
Secondary structure
SS confidence
Disorder																					?													?	?	?	?	?	?														?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	L	G	H	Q	A	A	D	R	E	I	A	H	R	A	D	S	V	G	C	S	R	Q	D	V	E	N	A	L	A	A	A	A	R	V	A	D	G	Q	S	L	S	D	T	E	L	A	R	L	G	C	A	L	G	D	A	R	V	R	D
Secondary structure
SS confidence
Disorder					?			?	?		?	?	?	?	?	?	?	?	?																	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		M	L	Y	A	L	A	V	G	E	N	A	G	A	A	E	S	L	W	A	L	L	A	R	V	L	P	E	P	W	R	V	E	A	L	V	L	L	A	F	S	A	Y	A	R	G	D	G	P	L	A	G	V	S	L	Q	A	A	L	C	C
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.
Sequence		E	P	G	H	R	M	A	G	M	L	D	T	A	L	Q	S	G	L	R	P	E	H	I	R	D	I	A	V	T	G	Y	Q	R	A	E	Q	L	G	I	R	L	P	P	R	R	A	F	G	Q	R	A	G
Secondary structure
SS confidence
Disorder																																						?							?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 51%) Beta strand ( 11%)

Rank Aligned region

PDB 2pqr chain B domain 1 Region: 242 - 316 Aligned: 74 Modelled: 75 Confidence: 85.8% Identity: 15% Fold: alpha-alpha superhelix Superfamily: TPR-like Family: Tetratricopeptide repeat (TPR) Phyre2 PDB 1nzn chain A Region: 251 - 316 Aligned: 66 Modelled: 66 Confidence: 79.7% Identity: 17% Fold: alpha-alpha superhelix Superfamily: TPR-like Family: Tetratricopeptide repeat (TPR) Phyre2 PDB 2qlc chain C Region: 8 - 124 Aligned: 115 Modelled: 117 Confidence: 77.7% Identity: 10% PDB header:dna binding protein Chain: C: PDB Molecule:dna repair protein radc homolog; PDBTitle: the crystal structure of dna repair protein radc from chlorobium2 tepidum tls Phyre2 PDB 1y8m chain A domain 1 Region: 250 - 316 Aligned: 66 Modelled: 67 Confidence: 70.5% Identity: 15% Fold: alpha-alpha superhelix Superfamily: TPR-like Family: Tetratricopeptide repeat (TPR) Phyre2 PDB 1iyg chain A Region: 251 - 315 Aligned: 65 Modelled: 65 Confidence: 59.0% Identity: 17% Fold: alpha-alpha superhelix Superfamily: TPR-like Family: Tetratricopeptide repeat (TPR) Phyre2 PDB 4f3v chain B Region: 241 - 311 Aligned: 71 Modelled: 71 Confidence: 48.0% Identity: 17% PDB header:protein transport Chain: B: PDB Molecule:esx-1 secretion system protein ecca1; PDBTitle: crystal structure of n-terminal domain of ecca1 atpase from esx-12 secretion system of mycobacterium tuberculosis Phyre2 PDB 4ui9 chain K Region: 250 - 315 Aligned: 64 Modelled: 66 Confidence: 47.4% Identity: 13% PDB header:cell cycle Chain: K: PDB Molecule:cell division cycle protein 16 homolog; PDBTitle: atomic structure of the human anaphase-promoting complex Phyre2 PDB 2xpi chain A Region: 241 - 315 Aligned: 73 Modelled: 75 Confidence: 38.7% Identity: 19% PDB header:cell cycle Chain: A: PDB Molecule:anaphase-promoting complex subunit cut9; PDBTitle: crystal structure of apc/c hetero-tetramer cut9-hcn1 Phyre2 PDB 1pc2 chain A Region: 240 - 316 Aligned: 77 Modelled: 77 Confidence: 32.8% Identity: 16% Fold: alpha-alpha superhelix Superfamily: TPR-like Family: Tetratricopeptide repeat (TPR) Phyre2 PDB 1tjc chain A Region: 266 - 308 Aligned: 43 Modelled: 43 Confidence: 30.9% Identity: 26% Fold: alpha-alpha superhelix Superfamily: TPR-like Family: Tetratricopeptide repeat (TPR) Phyre2 PDB 3bee chain B Region: 240 - 315 Aligned: 74 Modelled: 76 Confidence: 30.5% Identity: 15% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative yfre protein; PDBTitle: crystal structure of putative yfre protein from vibrio2 parahaemolyticus Phyre2 PDB 5tmx chain A Region: 308 - 330 Aligned: 23 Modelled: 23 Confidence: 30.1% Identity: 22% PDB header:transcription regulator Chain: A: PDB Molecule:protein sini; PDBTitle: solution structure of sini, antagonist to the master biofilm-regulator2 sinr in bacillus subtilis Phyre2 PDB 4fm4 chain C Region: 317 - 343 Aligned: 27 Modelled: 27 Confidence: 28.3% Identity: 22% PDB header:lyase Chain: C: PDB Molecule:nitrile hydratase alpha subunit; PDBTitle: wild type fe-type nitrile hydratase from comamonas testosteroni ni1 Phyre2 PDB 1i94 chain L Region: 7 - 35 Aligned: 29 Modelled: 29 Confidence: 27.4% Identity: 24% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Cold shock DNA-binding domain-like Phyre2 PDB 2ics chain A domain 2 Region: 302 - 340 Aligned: 37 Modelled: 39 Confidence: 26.5% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: Adenine deaminase-like Phyre2 PDB 2uub chain L domain 1 Region: 7 - 35 Aligned: 29 Modelled: 29 Confidence: 22.4% Identity: 24% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Cold shock DNA-binding domain-like Phyre2 PDB 3j6v chain L Region: 7 - 35 Aligned: 29 Modelled: 29 Confidence: 19.6% Identity: 21% PDB header:ribosome Chain: L: PDB Molecule:28s ribosomal protein s12, mitochondrial; PDBTitle: cryo-em structure of the small subunit of the mammalian mitochondrial2 ribosome Phyre2 PDB 1zn1 chain L Region: 7 - 35 Aligned: 29 Modelled: 29 Confidence: 19.4% Identity: 14% PDB header:biosynthetic/structural protein/rna Chain: L: PDB Molecule:30s ribosomal protein s12; PDBTitle: coordinates of rrf fitted into cryo-em map of the 70s post-termination2 complex Phyre2 PDB 1i0d chain A Region: 302 - 341 Aligned: 38 Modelled: 40 Confidence: 16.5% Identity: 18% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: Phosphotriesterase-like Phyre2 PDB 1g5a chain A domain 1 Region: 21 - 36 Aligned: 16 Modelled: 16 Confidence: 15.8% Identity: 19% Fold: Glycosyl hydrolase domain Superfamily: Glycosyl hydrolase domain Family: alpha-Amylases, C-terminal beta-sheet domain Phyre2 1 d2pqrb1 2 d1nzna_ 3 c2qlcC_ 4 d1y8ma1 5 d1iyga_ 6 c4f3vB_ 7 c4ui9K_ 8 c2xpiA_ 9 d1pc2a_ 10 d1tjca_ 11 c3beeB_ 12 c5tmxA_ 13 c4fm4C_ 14 d1i94l_ 15 d2icsa2 16 d2uubl1 17 c3j6vL_ 18 c1zn1L_ 19 d1i0da_ 20 d1g5aa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79