1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	N	G	Q	R	G	Q	L	S	T	L	I	G	R	T	L	L	G	L	A	A	T	A	V	T	A	V	L	L	A	P	T	V	A	A	S	P	M	G	D	A	E	D	A	M	M	A	A	W	E	K	A	G	G	D	T	S	T	L	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	R	K	G	D	V	Y	P	I	G	D	G	F	A	L	D	F	A	G	G	K	M	F	F	T	P	A	T	G	A	K	Y	L	Y	G	P	L	L	D	K	Y	E	S	L	G	G	A	A	D	S	D	L	G	F	P	T	I	N	E	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	G	L	A	G	P	D	S	R	V	S	T	F	S	A	A	D	N	P	V	I	F	W	T	P	E	H	G	A	F	V	V	R	G	A	L	N	A	A	W	D	K	L	G	S	S	G	G	V	L	G	A	P	V	G	D	E	T	Y	D
Secondary structure
SS confidence
Disorder																																													?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	E	V	T	A	Q	K	F	S	G	G	E	V	S	W	N	R	A	T	K	E	F	T	T	V	P	A	V	L	A	E	Q	L	K	G	L	Q	V	A	I	D	P	S	A	A	I	N	M	A	W	R	A	A	G	G	A	A	G	P	L
Secondary structure
SS confidence
Disorder																															?					?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	A	K	K	G	G	Q	Y	P	I	G	G	D	G	I	A	Q	D	F	V	G	G	K	V	F	F	S	P	A	T	G	A	N	A	V	E	G	E	I	L	A	K	Y	E	S	L	G	G	P	V	S	S	D	L	G	F	P	I	A	N
Secondary structure
SS confidence
Disorder																																																	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		E	T	D	G	G	F	G	P	S	S	R	I	V	R	F	S	A	A	D	K	P	V	I	F	W	T	P	D	H	G	A	F	V	V	R	G	A	M	V	A	A	W	D	K	L	R	G	P	N	G	K	L	G	A	P	V	G	D	Q	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																								?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	D	G	D	V	V	S	Q	K	F	T	G	G	M	I	S	W	N	R	A	K	N	T	F	T	T	D	P	A	N	L	A	P	L	L	S	G	L	Q	V	S	G	Q	N	Q	P	S	T	S	A	M	P	P	P	G	K	K	F	T	W
Secondary structure
SS confidence
Disorder			?	?																																	?				?	?	?		?					?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		H	W	W	W	L	G	A	A	A	L	G	V	L	L	V	V	M	V	A	L	V	V	F	G	L	R	R	R	R	R	G	Y	D	A	A	A	Y	D	D	D	R	A	G	D	V	E	Y	G	T	A	A	D	G	D	W	P	P	D	E	D
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		F	G	S	E	H	F	G	F	G	D	Q	F	P	P	E	P	V	A	P	D	A	G	S	T	P	R	V	S	W	P	R	G	A	G	A	A	V	G	D	A	E	H	L	P	G	E	E	G	Y	G	S	D	L	L	S	G	P	S	N	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		G	V	E	E	E	D	T	D	A	V	D	T	T	P	T	P	V	V	S	Q	A	D	L	S	E	V	G	P	D	L	I	V	P	E	R	V	V	P	E	T	F	V	P	Q	A	F	V	P	E	A	V	A	P	E	A	V	P	P	D	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		H	A	A	D	L	A	D	T	G	L	P	A	A	A	V	S	A	A	E	D	R	G	G	R	H	A	A	A	E	P	P	E	P	P	S	A	G	V	R	P	A	I	H	L	P	L	E	D	P	Y	Q	M	P	N	G	Y	P	V	K	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.
Sequence		S	V	S	F	G	L	Y	Y	P	P	G	S	A	L	Y	H	D	T	L	A	E	L	W	F	A	S	E	E	V	A	Q	V	N	G	F	I	R	A	D
Secondary structure
SS confidence
Disorder																												?						?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 41%) Alpha helix ( 10%) Beta strand ( 17%)

Rank Aligned region

PDB 1f3m chain B Region: 375 - 419 Aligned: 45 Modelled: 45 Confidence: 96.9% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase pak-alpha; PDBTitle: crystal structure of human serine/threonine kinase pak1 Phyre2 PDB 1e0a chain B Region: 375 - 406 Aligned: 32 Modelled: 32 Confidence: 94.1% Identity: 22% PDB header:signalling protein/kinase Chain: B: PDB Molecule:serine/threonine-protein kinase pak-alpha; PDBTitle: cdc42 complexed with the gtpase binding domain of p212 activated kinase Phyre2 PDB 2lnh chain A Region: 375 - 407 Aligned: 33 Modelled: 33 Confidence: 83.0% Identity: 12% PDB header:signaling protein/protein binding Chain: A: PDB Molecule:neural wiskott-aldrich syndrome protein; PDBTitle: enterohaemorrhagic e. coli (ehec) exploits a tryptophan switch to2 hijack host f-actin assembly Phyre2 PDB 2odb chain B Region: 375 - 395 Aligned: 21 Modelled: 21 Confidence: 79.9% Identity: 19% PDB header:protein binding Chain: B: PDB Molecule:serine/threonine-protein kinase pak 6; PDBTitle: the crystal structure of human cdc42 in complex with the crib domain2 of human p21-activated kinase 6 (pak6) Phyre2 PDB 1cee chain B Region: 369 - 407 Aligned: 39 Modelled: 39 Confidence: 77.7% Identity: 15% PDB header:structural protein regulation Chain: B: PDB Molecule:wiskott-aldrich syndrome protein wasp; PDBTitle: solution structure of cdc42 in complex with the gtpase2 binding domain of wasp Phyre2 PDB 2ov2 chain O Region: 375 - 395 Aligned: 21 Modelled: 21 Confidence: 76.3% Identity: 19% PDB header:protein binding/transferase Chain: O: PDB Molecule:serine/threonine-protein kinase pak 4; PDBTitle: the crystal structure of the human rac3 in complex with the crib2 domain of human p21-activated kinase 4 (pak4) Phyre2 PDB 2k42 chain A Region: 377 - 407 Aligned: 31 Modelled: 31 Confidence: 70.9% Identity: 16% PDB header:signaling protein Chain: A: PDB Molecule:wiskott-aldrich syndrome protein; PDBTitle: solution structure of the gtpase binding domain of wasp in2 complex with espfu, an ehec effector Phyre2 PDB 6nbx chain G Region: 415 - 472 Aligned: 58 Modelled: 58 Confidence: 58.5% Identity: 14% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase subunit j; PDBTitle: t.elongatus ndh (data-set 2) Phyre2 PDB 2iyj chain A Region: 225 - 281 Aligned: 50 Modelled: 57 Confidence: 43.2% Identity: 18% PDB header:isomerase Chain: A: PDB Molecule:thiol disulfide interchange protein dsbc; PDBTitle: crystal structure of the n-terminal dimer domain of e.coli2 dsbc Phyre2 PDB 1eej chain A domain 2 Region: 225 - 281 Aligned: 50 Modelled: 57 Confidence: 37.0% Identity: 18% Fold: Cystatin-like Superfamily: DsbC/DsbG N-terminal domain-like Family: DsbC/DsbG N-terminal domain-like Phyre2 PDB 1odh chain A Region: 167 - 199 Aligned: 25 Modelled: 33 Confidence: 34.9% Identity: 20% Fold: GCM domain Superfamily: GCM domain Family: GCM domain Phyre2 PDB 6hq8 chain B Region: 310 - 326 Aligned: 17 Modelled: 17 Confidence: 25.6% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:beta-1,3-oligosaccharide phosphorylase; PDBTitle: bacterial beta-1,3-oligosaccharide phosphorylase from gh149 with2 laminarihexaose bound at a surface site Phyre2 PDB 1f5j chain A Region: 324 - 354 Aligned: 31 Modelled: 31 Confidence: 22.5% Identity: 19% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Xylanase/endoglucanase 11/12 Phyre2 PDB 2yh5 chain A Region: 331 - 372 Aligned: 42 Modelled: 42 Confidence: 21.6% Identity: 26% PDB header:lipid binding protein Chain: A: PDB Molecule:dapx protein; PDBTitle: structure of the c-terminal domain of bamc Phyre2 PDB 3hfk chain B Region: 661 - 692 Aligned: 32 Modelled: 32 Confidence: 21.0% Identity: 34% PDB header:isomerase Chain: B: PDB Molecule:4-methylmuconolactone methylisomerase; PDBTitle: crystal structure of 4-methylmuconolactone methylisomerase (h52a) in2 complex with 4-methylmuconolactone Phyre2 PDB 1t3b chain A domain 2 Region: 240 - 281 Aligned: 42 Modelled: 42 Confidence: 20.8% Identity: 12% Fold: Cystatin-like Superfamily: DsbC/DsbG N-terminal domain-like Family: DsbC/DsbG N-terminal domain-like Phyre2 PDB 1igo chain A Region: 324 - 354 Aligned: 31 Modelled: 31 Confidence: 20.5% Identity: 26% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Xylanase/endoglucanase 11/12 Phyre2 PDB 2c1f chain A Region: 324 - 354 Aligned: 31 Modelled: 31 Confidence: 19.3% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:bifunctional endo-1,4-beta-xylanase a; PDBTitle: the structure of the family 11 xylanase from neocallimastix2 patriciarum Phyre2 PDB 2knc chain A Region: 422 - 459 Aligned: 38 Modelled: 38 Confidence: 18.9% Identity: 24% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2oru chain A Region: 374 - 385 Aligned: 12 Modelled: 12 Confidence: 15.9% Identity: 33% PDB header:de novo protein Chain: A: PDB Molecule:xtz1-peptide; PDBTitle: solution structure of xtz1-peptide, a beta-hairpin peptide2 with a structured extension Phyre2 1 c1f3mB_ 2 c1e0aB_ 3 c2lnhA_ 4 c2odbB_ 5 c1ceeB_ 6 c2ov2O_ 7 c2k42A_ 8 c6nbxG_ 9 c2iyjA_ 10 d1eeja2 11 d1odha_ 12 c6hq8B_ 13 d1f5ja_ 14 c2yh5A_ 15 c3hfkB_ 16 d1t3ba2 17 d1igoa_ 18 c2c1fA_ 19 c2kncA_ 20 c2oruA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35