1

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.

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.

10

.

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20

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30

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40

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.

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50

.

.

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.

60

Sequence

M

P

C

L

A

R

Q

P

V

D

L

P

P

W

A

G

P

R

C

G

P

Y

C

P

R

A

R

I

T

L

L

Q

R

T

T

I

A

K

S

N

R

K

Y

Y

E

N

G

Y

P

A

D

V

K

L

M

P

G

H

A

A

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

.

.

.

.

.

.

.

.

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80

.

.

Sequence

V

V

S

N

R

A

A

A

R

A

G

F

A

L

P

C

R

K

R

Q

P

D

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 46%) Alpha helix ( 9%) Beta strand ( 34%)

Rank Aligned region

PDB 1xm5 chain A Region: 28 - 52 Aligned: 25 Modelled: 25 Confidence: 18.1% Identity: 20% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Predicted metal-dependent hydrolase Phyre2 PDB 6ht4 chain A Region: 8 - 22 Aligned: 15 Modelled: 15 Confidence: 15.7% Identity: 47% PDB header:unknown function Chain: A: PDB Molecule:ns5a; PDBTitle: nmr structure of ns5a-d2 (jfh1) peptide (304-323) Phyre2 PDB 2mfr chain A Region: 77 - 82 Aligned: 6 Modelled: 6 Confidence: 14.0% Identity: 100% PDB header:transferase Chain: A: PDB Molecule:insulin receptor; PDBTitle: solution structure of the transmembrane domain of the insulin receptor2 in micelles Phyre2 PDB 1xax chain A Region: 28 - 52 Aligned: 25 Modelled: 25 Confidence: 13.9% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical upf0054 protein hi0004; PDBTitle: nmr structure of hi0004, a putative essential gene product2 from haemophilus influenzae Phyre2 PDB 1qcs chain A domain 1 Region: 34 - 78 Aligned: 45 Modelled: 45 Confidence: 13.4% Identity: 29% Fold: Double psi beta-barrel Superfamily: ADC-like Family: Cdc48 N-terminal domain-like Phyre2 PDB 1tvi chain A Region: 28 - 52 Aligned: 25 Modelled: 25 Confidence: 11.9% Identity: 24% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Predicted metal-dependent hydrolase Phyre2 PDB 2n73 chain B Region: 1 - 22 Aligned: 22 Modelled: 22 Confidence: 11.8% Identity: 32% PDB header:transferase/transferase regulator Chain: B: PDB Molecule:phosphatidylinositol 4-kinase beta; PDBTitle: solution structure of the acbd3:pi4kb complex Phyre2 PDB 5od4 chain A Region: 20 - 62 Aligned: 35 Modelled: 43 Confidence: 10.9% Identity: 31% PDB header:unknown function Chain: A: PDB Molecule:secreted in xylem 3; PDBTitle: avr2 effector protein from the fungal plant pathogen fusarium2 oxysporum Phyre2 PDB 2esy chain A Region: 65 - 76 Aligned: 12 Modelled: 12 Confidence: 9.7% Identity: 42% PDB header:lipid binding protein Chain: A: PDB Molecule:lung surfactant protein c; PDBTitle: structure and influence on stability and activity of the n-2 terminal propetide part of lung surfactant protein c Phyre2 PDB 3k8h chain A Region: 37 - 62 Aligned: 25 Modelled: 26 Confidence: 9.2% Identity: 28% PDB header:membrane protein Chain: A: PDB Molecule:30klp; PDBTitle: structure of crystal form i of tp0453 Phyre2 PDB 1oz9 chain A Region: 28 - 52 Aligned: 25 Modelled: 25 Confidence: 9.2% Identity: 24% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Predicted metal-dependent hydrolase Phyre2 PDB 1na6 chain A domain 1 Region: 39 - 50 Aligned: 12 Modelled: 12 Confidence: 9.2% Identity: 25% Fold: DNA-binding pseudobarrel domain Superfamily: DNA-binding pseudobarrel domain Family: Type II restriction endonuclease effector domain Phyre2 PDB 1x99 chain A Region: 35 - 47 Aligned: 13 Modelled: 13 Confidence: 8.5% Identity: 46% Fold: Cytolysin/lectin Superfamily: Cytolysin/lectin Family: Fungal fruit body lectin Phyre2 PDB 3la6 chain P Region: 28 - 51 Aligned: 24 Modelled: 24 Confidence: 8.4% Identity: 29% PDB header:transferase Chain: P: PDB Molecule:tyrosine-protein kinase wzc; PDBTitle: octameric kinase domain of the e. coli tyrosine kinase wzc with bound2 adp Phyre2 PDB 2h28 chain A domain 1 Region: 10 - 28 Aligned: 19 Modelled: 19 Confidence: 8.2% Identity: 37% Fold: Profilin-like Superfamily: YeeU-like Family: YagB/YeeU/YfjZ-like Phyre2 PDB 2eoc chain A Region: 20 - 44 Aligned: 25 Modelled: 25 Confidence: 7.8% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 3; PDBTitle: solution structure of the wgr domain from human poly [adp-2 ribose] polymerase-3 Phyre2 PDB 4v19 chain 4 Region: 33 - 52 Aligned: 20 Modelled: 20 Confidence: 7.6% Identity: 25% PDB header:ribosome Chain: 4: PDB Molecule:mitoribosomal protein bl31m, mrpl55; PDBTitle: structure of the large subunit of the mammalian mitoribosome, part 12 of 2 Phyre2 PDB 4yam chain A Region: 10 - 30 Aligned: 21 Modelled: 21 Confidence: 7.2% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:beta-etherase; PDBTitle: crystal structure of lige-apo form from sphingobium sp. strain syk-6 Phyre2 PDB 3iyn chain R Region: 11 - 20 Aligned: 10 Modelled: 10 Confidence: 7.0% Identity: 60% PDB header:virus Chain: R: PDB Molecule:hexon-associated protein; PDBTitle: 3.6-angstrom cryoem structure of human adenovirus type 5 Phyre2 PDB 1rk4 chain A domain 2 Region: 19 - 30 Aligned: 12 Modelled: 12 Confidence: 6.9% Identity: 25% Fold: Thioredoxin fold Superfamily: Thioredoxin-like Family: Glutathione S-transferase (GST), N-terminal domain Phyre2 1 d1xm5a_ 2 c6ht4A_ 3 c2mfrA_ 4 c1xaxA_ 5 d1qcsa1 6 d1tvia_ 7 c2n73B_ 8 c5od4A_ 9 c2esyA_ 10 c3k8hA_ 11 d1oz9a_ 12 d1na6a1 13 d1x99a_ 14 c3la6P_ 15 d2h28a1 16 c2eocA_ 17 c4v194_ 18 c4yamA_ 19 c3iynR_ 20 d1rk4a2 21 22 23 24 25 26 27 28 29