1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	S	V	E	F	A	T	I	L	A	L	G	A	A	L	L	A	G	I	G	Y	V	T	L	Q	R	S	A	R	Q	V	T	A	E	E	Y	V	G	H	F	T	L	F	H	L	S	L	R	H	A	L	W	W	L	G	S	L	A	A
Secondary structure
SS confidence
Disorder		?	?	?																												?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	S	F	T	L	Q	A	I	A	L	T	M	G	S	V	V	L	V	Q	S	L	Q	A	T	A	L	L	F	A	L	L	I	D	A	R	L	T	H	H	R	C	T	P	R	E	W	M	W	A	V	L	L	A	G	A	V	A	V	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	M	S	G	N	P	A	A	G	T	T	R	A	P	F	S	T	W	A	V	V	A	V	V	V	V	P	A	V	V	L	C	V	V	G	A	R	I	A	S	G	S	L	S	A	V	L	L	A	V	A	S	S	A	T	L	A	V	F	T
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?	?	?	?																						?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	L	T	K	G	V	V	T	E	L	G	E	G	F	A	T	L	I	R	T	P	A	L	Y	A	W	I	L	V	L	P	I	G	L	M	L	Q	Q	S	S	L	R	V	G	A	L	T	A	S	L	P	T	I	T	V	A	R	P	V	I
Secondary structure
SS confidence
Disorder										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	S	V	L	G	I	T	V	L	D	E	V	L	H	T	G	R	V	A	L	V	A	L	V	A	A	V	V	V	V	V	V	A	T	V	A	L	A	R	D	E	V	A	M	M	T	V	S	A	G	E	L	G	A	A	G	Q	L	A	V
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.
Sequence		R
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 76%) Beta strand ( 0%) TM helix ( 60%) (View membrane topology prediction)

Rank Aligned region

PDB 5i20 chain E Region: 3 - 288 Aligned: 274 Modelled: 286 Confidence: 100.0% Identity: 16% PDB header:membrane protein Chain: E: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein Phyre2 PDB 5i20 chain C Region: 3 - 283 Aligned: 264 Modelled: 281 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein Phyre2 PDB 6oh2 chain A Region: 12 - 281 Aligned: 263 Modelled: 270 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:cmp-sialic acid transporter; PDBTitle: x-ray crystal structure of the mouse cmp-sialic acid transporter in2 complex with cmp, by lipidic cubic phase Phyre2 PDB 5oge chain E Region: 7 - 288 Aligned: 275 Modelled: 276 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: E: PDB Molecule:gdp-mannose transporter 1; PDBTitle: crystal structure of a nucleotide sugar transporter Phyre2 PDB 6i1r chain A Region: 8 - 287 Aligned: 273 Modelled: 280 Confidence: 100.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:cmp-sialic acid transporter 1; PDBTitle: crystal structure of cmp bound cst in an outward facing conformation Phyre2 PDB 5y79 chain A Region: 9 - 283 Aligned: 268 Modelled: 269 Confidence: 99.9% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:putative hexose phosphate translocator; PDBTitle: crystal structure of the triose-phosphate/phosphate translocator in2 complex with 3-phosphoglycerate Phyre2 PDB 1s7b chain A Region: 9 - 129 Aligned: 105 Modelled: 105 Confidence: 97.7% Identity: 19% Fold: Multidrug resistance efflux transporter EmrE Superfamily: Multidrug resistance efflux transporter EmrE Family: Multidrug resistance efflux transporter EmrE Phyre2 PDB 6nbx chain G Region: 250 - 301 Aligned: 52 Modelled: 52 Confidence: 15.4% Identity: 12% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase subunit j; PDBTitle: t.elongatus ndh (data-set 2) Phyre2 PDB 2i68 chain B Region: 207 - 278 Aligned: 55 Modelled: 72 Confidence: 14.6% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:protein emre; PDBTitle: cryo-em based theoretical model structure of transmembrane2 domain of the multidrug-resistance antiporter from e. coli3 emre Phyre2 PDB 6hwh chain B Region: 41 - 71 Aligned: 31 Modelled: 31 Confidence: 11.5% Identity: 19% PDB header:electron transport Chain: B: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 3a0h chain L Region: 2 - 19 Aligned: 18 Modelled: 18 Confidence: 7.5% Identity: 33% PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of i-substituted photosystem ii complex Phyre2 PDB 3a0h chain L Region: 2 - 19 Aligned: 18 Modelled: 18 Confidence: 7.5% Identity: 33% PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of i-substituted photosystem ii complex Phyre2 PDB 2lp1 chain A Region: 248 - 276 Aligned: 29 Modelled: 29 Confidence: 6.8% Identity: 21% PDB header:membrane protein Chain: A: PDB Molecule:c99; PDBTitle: the solution nmr structure of the transmembrane c-terminal domain of2 the amyloid precursor protein (c99) Phyre2 PDB 3a0b chain L Region: 2 - 23 Aligned: 22 Modelled: 22 Confidence: 5.9% Identity: 27% PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of br-substituted photosystem ii complex Phyre2 PDB 3a0b chain L Region: 2 - 23 Aligned: 22 Modelled: 22 Confidence: 5.9% Identity: 27% PDB header:electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: crystal structure of br-substituted photosystem ii complex Phyre2 PDB 3o7p chain A Region: 53 - 238 Aligned: 185 Modelled: 186 Confidence: 5.3% Identity: 5% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 4pj0 chain L Region: 3 - 23 Aligned: 21 Modelled: 21 Confidence: 5.3% Identity: 29% PDB header:oxidoreductase, electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: structure of t.elongatus photosystem ii, rows of dimers crystal2 packing Phyre2 PDB 4pj0 chain L Region: 3 - 23 Aligned: 21 Modelled: 21 Confidence: 5.3% Identity: 29% PDB header:oxidoreductase, electron transport Chain: L: PDB Molecule:photosystem ii reaction center protein l; PDBTitle: structure of t.elongatus photosystem ii, rows of dimers crystal2 packing Phyre2 PDB 4m5b chain A Region: 129 - 278 Aligned: 149 Modelled: 150 Confidence: 5.3% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:cobalamin biosynthesis protein cbim; PDBTitle: crystal structure of an truncated transition metal transporter Phyre2 PDB 4m5c chain A Region: 129 - 278 Aligned: 149 Modelled: 150 Confidence: 5.3% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:cobalamin biosynthesis protein cbim; PDBTitle: crystal structure of an truncated transition metal transporter Phyre2 1 c5i20E_ 2 c5i20C_ 3 c6oh2A_ 4 c5ogeE_ 5 c6i1rA_ 6 c5y79A_ 7 d1s7ba_ 8 c6nbxG_ 9 c2i68B_ 10 c6hwhb_ 11 c3a0hL_ 12 c3a0hl_ 13 c2lp1A_ 14 c3a0bl_ 15 c3a0bL_ 16 c3o7pA_ 17 c4pj0L_ 18 c4pj0l_ 19 c4m5bA_ 20 c4m5cA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56