1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	R	E	W	S	Y	W	T	R	N	K	L	E	I	L	A	G	Y	L	P	A	F	N	R	A	S	Q	T	S	R	E	R	I	Y	L	D	L	M	A	G	Q	P	E	N	I	D	R	D	M	G	E	K	F	D	G	S	S	L	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																							?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	M	K	A	D	P	P	F	T	R	L	R	F	C	E	L	N	P	L	A	S	E	L	D	V	A	L	R	T	R	F	P	G	D	G	R	Y	R	V	V	A	G	D	S	N	V	T	I	D	E	T	L	A	E	L	G	P	W	R	W
Secondary structure
SS confidence
Disorder																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	P	T	F	A	F	I	D	Q	Q	A	A	E	V	H	W	E	T	I	N	K	V	A	A	F	R	Q	N	P	R	N	L	K	T	E	L	W	M	L	M	S	P	T	M	I	A	R	G	V	K	G	T	N	A	E	L	F	I	E	Q
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?																						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	T	R	M	Y	G	D	A	D	W	K	R	I	Q	A	A	R	W	R	H	H	L	T	A	P	A	Y	R	A	E	M	V	N	L	M	R	V	K	L	E	Y	E	L	G	Y	K	Y	S	H	R	I	P	M	Q	M	H	N	K	V	T
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	F	D	M	V	F	A	T	D	H	W	A	G	D	A	I	M	C	H	L	Y	N	R	A	A	Q	K	E	P	E	M	M	R	Q	A	K	S	A	K	Q	Q	K	E	S	E	D	R	G	E	M	G	L	F	S	V	G	E	L	A	V
Secondary structure
SS confidence
Disorder																										?	?	?	?										?	?	?		?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330
Sequence		Q	D	S	N	A	G	Q	I	L	W	A	P	S	P	T	W	D	P	R	A	R	G	W	W	S	E	D	P	G	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?			?	?	?	?	?									?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 45%) Beta strand ( 16%)

Rank Aligned region

PDB 4blu chain B Region: 11 - 129 Aligned: 109 Modelled: 119 Confidence: 98.7% Identity: 27% PDB header:transferase Chain: B: PDB Molecule:ribosomal rna large subunit methyltransferase j; PDBTitle: crystal structure of escherichia coli 23s rrna (a2030-n6)-2 methyltransferase rlmj Phyre2 PDB 2oo3 chain A domain 1 Region: 11 - 129 Aligned: 109 Modelled: 119 Confidence: 98.6% Identity: 23% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: LPG1296-like Phyre2 PDB 2fhp chain A domain 1 Region: 20 - 146 Aligned: 110 Modelled: 112 Confidence: 97.0% Identity: 15% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: YhhF-like Phyre2 PDB 2dul chain A domain 1 Region: 34 - 136 Aligned: 83 Modelled: 103 Confidence: 96.8% Identity: 18% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: TRM1-like Phyre2 PDB 3axt chain A Region: 30 - 247 Aligned: 174 Modelled: 196 Confidence: 96.4% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:probable n(2),n(2)-dimethylguanosine trna methyltransferase PDBTitle: complex structure of trna methyltransferase trm1 from aquifex aeolicus2 with s-adenosyl-l-methionine Phyre2 PDB 5xj2 chain C Region: 13 - 161 Aligned: 122 Modelled: 134 Confidence: 96.3% Identity: 16% PDB header:transferase/rna Chain: C: PDB Molecule:uncharacterized rna methyltransferase sp_1029; PDBTitle: structure of sprlmcd with u747 rna Phyre2 PDB 1m6y chain A Region: 20 - 128 Aligned: 91 Modelled: 95 Confidence: 96.3% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:s-adenosyl-methyltransferase mraw; PDBTitle: crystal structure analysis of tm0872, a putative sam-dependent2 methyltransferase, complexed with sah Phyre2 PDB 3ll7 chain A Region: 36 - 129 Aligned: 73 Modelled: 81 Confidence: 96.1% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:putative methyltransferase; PDBTitle: crystal structure of putative methyltransferase pg_1098 from2 porphyromonas gingivalis w83 Phyre2 PDB 1wg8 chain B Region: 20 - 128 Aligned: 86 Modelled: 109 Confidence: 95.5% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:predicted s-adenosylmethionine-dependent PDBTitle: crystal structure of a predicted s-adenosylmethionine-2 dependent methyltransferase tt1512 from thermus3 thermophilus hb8. Phyre2 PDB 2r6z chain A Region: 36 - 129 Aligned: 75 Modelled: 77 Confidence: 95.3% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:upf0341 protein in rsp 3' region; PDBTitle: crystal structure of the sam-dependent methyltransferase ngo1261 from2 neisseria gonorrhoeae, northeast structural genomics consortium3 target ngr48 Phyre2 PDB 2as0 chain A domain 2 Region: 17 - 129 Aligned: 94 Modelled: 99 Confidence: 95.3% Identity: 13% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: hypothetical RNA methyltransferase Phyre2 PDB 2esr chain B Region: 23 - 146 Aligned: 103 Modelled: 111 Confidence: 95.3% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:methyltransferase; PDBTitle: conserved hypothetical protein- streptococcus pyogenes Phyre2 PDB 1uwv chain A Region: 14 - 161 Aligned: 118 Modelled: 133 Confidence: 95.2% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:23s rrna (uracil-5-)-methyltransferase ruma; PDBTitle: crystal structure of ruma, the iron-sulfur cluster2 containing e. coli 23s ribosomal rna 5-methyluridine3 methyltransferase Phyre2 PDB 1uwv chain A domain 2 Region: 13 - 161 Aligned: 121 Modelled: 134 Confidence: 95.1% Identity: 11% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: (Uracil-5-)-methyltransferase Phyre2 PDB 4gf5 chain S Region: 4 - 128 Aligned: 114 Modelled: 117 Confidence: 94.8% Identity: 19% PDB header:transferase Chain: S: PDB Molecule:cals11; PDBTitle: crystal structure of calicheamicin methyltransferase, cals11 Phyre2 PDB 5zy5 chain B Region: 70 - 128 Aligned: 57 Modelled: 59 Confidence: 94.6% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:probable catechol o-methyltransferase 1; PDBTitle: spcomt apo structure Phyre2 PDB 2cl5 chain A domain 1 Region: 9 - 128 Aligned: 99 Modelled: 106 Confidence: 94.5% Identity: 17% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: COMT-like Phyre2 PDB 2avd chain A domain 1 Region: 17 - 185 Aligned: 146 Modelled: 152 Confidence: 94.2% Identity: 19% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: COMT-like Phyre2 PDB 2fpo chain A domain 1 Region: 36 - 146 Aligned: 89 Modelled: 98 Confidence: 94.2% Identity: 22% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: YhhF-like Phyre2 PDB 3v8v chain B Region: 17 - 106 Aligned: 82 Modelled: 90 Confidence: 94.1% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:ribosomal rna large subunit methyltransferase l; PDBTitle: crystal structure of bifunctional methyltransferase ycby (rlmlk) from2 escherichia coli, sam binding Phyre2 1 c4bluB_ 2 d2oo3a1 3 d2fhpa1 4 d2dula1 5 c3axtA_ 6 c5xj2C_ 7 c1m6yA_ 8 c3ll7A_ 9 c1wg8B_ 10 c2r6zA_ 11 d2as0a2 12 c2esrB_ 13 c1uwvA_ 14 d1uwva2 15 c4gf5S_ 16 c5zy5B_ 17 d2cl5a1 18 d2avda1 19 d2fpoa1 20 c3v8vB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185