1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	E	L	T	E	T	S	P	E	T	P	E	T	T	E	A	I	R	A	V	E	A	F	L	N	A	L	Q	N	E	D	F	D	T	V	D	A	A	L	G	D	D	L	V	Y	E	N	V	G	F	S	R	I	R	G	G	R	R	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	T	L	L	R	R	M	Q	G	R	V	G	F	E	V	K	I	H	R	I	G	A	D	G	A	A	V	L	T	E	R	T	D	A	L	I	I	G	P	L	R	V	Q	F	W	V	C	G	V	F	E	V	D	D	G	R	I	T	L	W
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.
Sequence		R	D	Y	F	D	V	Y	D	M	F	K	G	L	L	R	G	L	V	A	L	V	V	P	S	L	K	A	T	L
Secondary structure
SS confidence
Disorder																?	?	?	?	?	?	?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 29%) Beta strand ( 34%)

Rank Aligned region

PDB 2bng chain A domain 1 Region: 13 - 144 Aligned: 132 Modelled: 132 Confidence: 100.0% Identity: 98% Fold: Cystatin-like Superfamily: NTF2-like Family: Limonene-1,2-epoxide hydrolase-like Phyre2 PDB 1nww chain A Region: 4 - 138 Aligned: 133 Modelled: 135 Confidence: 99.9% Identity: 26% Fold: Cystatin-like Superfamily: NTF2-like Family: Limonene-1,2-epoxide hydrolase-like Phyre2 PDB 3k0z chain B Region: 2 - 138 Aligned: 135 Modelled: 135 Confidence: 99.9% Identity: 18% PDB header:lyase Chain: B: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of putative polyketide cyclase (np_977253.1) from2 bacillus cereus atcc 10987 at 1.91 a resolution Phyre2 PDB 3dm8 chain A domain 1 Region: 15 - 134 Aligned: 120 Modelled: 120 Confidence: 99.9% Identity: 14% Fold: Cystatin-like Superfamily: NTF2-like Family: Rpa4348-like Phyre2 PDB 5aig chain A Region: 17 - 134 Aligned: 118 Modelled: 118 Confidence: 99.9% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:limonene-1,2-epoxide hydrolase; PDBTitle: discovery and characterization of thermophilic limonene-1,2-epoxide2 hydrolases from hot spring metagenomic libraries. tomsk-sample-3 valpromide complex Phyre2 PDB 4h3u chain B Region: 17 - 143 Aligned: 125 Modelled: 127 Confidence: 99.9% Identity: 18% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of hypothetical protein with ketosteroid isomerase-2 like protein fold from catenulispora acidiphila dsm 44928 Phyre2 PDB 3ebt chain A domain 1 Region: 15 - 133 Aligned: 119 Modelled: 119 Confidence: 99.9% Identity: 17% Fold: Cystatin-like Superfamily: NTF2-like Family: SnoaL-like polyketide cyclase Phyre2 PDB 6d34 chain B Region: 14 - 133 Aligned: 120 Modelled: 120 Confidence: 99.9% Identity: 14% PDB header:biosynthetic protein Chain: B: PDB Molecule:terc; PDBTitle: apo crystal structure of terc, a terfestatin biosynthesis enzyme Phyre2 PDB 2gex chain A domain 1 Region: 13 - 138 Aligned: 123 Modelled: 126 Confidence: 99.9% Identity: 18% Fold: Cystatin-like Superfamily: NTF2-like Family: SnoaL-like polyketide cyclase Phyre2 PDB 3ec9 chain A domain 1 Region: 17 - 135 Aligned: 119 Modelled: 119 Confidence: 99.9% Identity: 15% Fold: Cystatin-like Superfamily: NTF2-like Family: PhzA/PhzB-like Phyre2 PDB 2gey chain A domain 1 Region: 15 - 147 Aligned: 128 Modelled: 133 Confidence: 99.9% Identity: 16% Fold: Cystatin-like Superfamily: NTF2-like Family: SnoaL-like polyketide cyclase Phyre2 PDB 3dmc chain A domain 1 Region: 5 - 126 Aligned: 122 Modelled: 0 Confidence: 99.9% Identity: 17% Fold: Cystatin-like Superfamily: NTF2-like Family: PhzA/PhzB-like Phyre2 PDB 5aii chain P Region: 17 - 135 Aligned: 119 Modelled: 119 Confidence: 99.9% Identity: 27% PDB header:hydrolase Chain: P: PDB Molecule:limonene-1,2-epoxide hydrolase; PDBTitle: discovery and characterization of thermophilic limonene-1,2-epoxide2 hydrolases from hot spring metagenomic libraries.3 ch55-sample-peg complex Phyre2 PDB 3f8h chain A Region: 17 - 134 Aligned: 118 Modelled: 117 Confidence: 99.9% Identity: 16% PDB header:unknown function Chain: A: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (tm1040_3560) from2 silicibacter sp. tm1040 at 2.00 a resolution Phyre2 PDB 2f99 chain A domain 1 Region: 15 - 138 Aligned: 122 Modelled: 124 Confidence: 99.9% Identity: 18% Fold: Cystatin-like Superfamily: NTF2-like Family: SnoaL-like polyketide cyclase Phyre2 PDB 3fh1 chain A Region: 7 - 125 Aligned: 116 Modelled: 119 Confidence: 99.9% Identity: 16% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized ntf2-like protein; PDBTitle: crystal structure of a ntf2-like protein of unknown function (mll8193)2 from mesorhizobium loti at 1.60 a resolution Phyre2 PDB 3fgy chain B Region: 12 - 133 Aligned: 122 Modelled: 121 Confidence: 99.9% Identity: 20% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized ntf2-like protein; PDBTitle: crystal structure of a ntf2-like protein (bxe_b1094) from burkholderia2 xenovorans lb400 at 1.59 a resolution Phyre2 PDB 5evh chain A Region: 14 - 134 Aligned: 116 Modelled: 121 Confidence: 99.9% Identity: 21% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of known function protein from kribbella flavida dsm2 17836 Phyre2 PDB 3b4o chain B Region: 14 - 147 Aligned: 128 Modelled: 134 Confidence: 99.9% Identity: 18% PDB header:biosynthetic protein Chain: B: PDB Molecule:phenazine biosynthesis protein a/b; PDBTitle: crystal structure of phenazine biosynthesis protein phza/b2 from burkholderia cepacia r18194, apo form Phyre2 PDB 3kkg chain A Region: 8 - 134 Aligned: 127 Modelled: 125 Confidence: 99.9% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:putative snoal-like polyketide cyclase; PDBTitle: crystal structure of putative snoal-like polyketide cyclase2 (yp_509242.1) from jannaschia sp. ccs1 at 1.40 a resolution Phyre2 1 d2bnga1 2 d1nwwa_ 3 c3k0zB_ 4 d3dm8a1 5 c5aigA_ 6 c4h3uB_ 7 d3ebta1 8 c6d34B_ 9 d2gexa1 10 d3ec9a1 11 d2geya1 12 d3dmca1 13 c5aiiP_ 14 c3f8hA_ 15 d2f99a1 16 c3fh1A_ 17 c3fgyB_ 18 c5evhA_ 19 c3b4oB_ 20 c3kkgA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159