1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	E	T	A	P	L	R	V	Q	L	I	A	K	T	D	F	L	A	P	P	D	V	P	W	T	T	D	A	D	G	G	P	A	L	V	E	F	A	G	R	A	C	Y	Q	S	W	S	K	P	N	P	K	T	A	T	N	A	G	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?						?			?	?			?	?						?																		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	R	H	I	I	D	V	G	H	F	S	V	L	E	H	A	S	V	S	F	Y	I	T	G	I	S	R	S	C	T	H	E	L	I	R	H	R	H	F	S	Y	S	Q	L	S	Q	R	Y	V	P	E	K	D	S	R	V	V	V	P	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	M	E	D	D	A	D	L	R	H	I	L	T	E	A	A	D	A	A	R	A	T	Y	S	E	L	L	A	K	L	E	A	K	F	A	D	Q	P	N	A	I	L	R	R	K	Q	A	R	Q	A	A	R	A	V	L	P	N	A	T	E
Secondary structure
SS confidence
Disorder					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	R	I	V	V	T	G	N	Y	R	A	W	R	H	F	I	A	M	R	A	S	E	H	A	D	V	E	I	R	R	L	A	I	E	C	L	R	Q	L	A	A	V	A	P	A	V	F	A	D	F	E	V	T	T	L	A	D	G	T	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250
Sequence		V	A	T	S	P	L	A	T	E	A
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 47%) Beta strand ( 16%)

Rank Aligned region

PDB 2af6 chain G Region: 3 - 248 Aligned: 246 Modelled: 246 Confidence: 100.0% Identity: 98% PDB header:transferase Chain: G: PDB Molecule:thymidylate synthase thyx; PDBTitle: crystal structure of mycobacterium tuberculosis flavin dependent2 thymidylate synthase (mtb thyx) in the presence of co-factor fad and3 substrate analog 5-bromo-2'-deoxyuridine-5'-monophosphate (brdump) Phyre2 PDB 3fnn chain A Region: 3 - 245 Aligned: 227 Modelled: 243 Confidence: 100.0% Identity: 64% PDB header:transferase Chain: A: PDB Molecule:thymidylate synthase thyx; PDBTitle: biochemical and structural analysis of an atypical thyx:2 corynebacterium glutamicum nchu 87078 depends on thya for3 thymidine biosynthesis Phyre2 PDB 6j61 chain B Region: 18 - 241 Aligned: 197 Modelled: 202 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:flavin-dependent thymidylate synthase; PDBTitle: crystal structure of thymidylate synthase, thy1, from thermus2 thermophilus having an extra c terminal domain Phyre2 PDB 1o26 chain A Region: 19 - 236 Aligned: 206 Modelled: 215 Confidence: 100.0% Identity: 21% Fold: Thymidylate synthase-complementing protein Thy1 Superfamily: Thymidylate synthase-complementing protein Thy1 Family: Thymidylate synthase-complementing protein Thy1 Phyre2 PDB 3ah5 chain E Region: 7 - 230 Aligned: 202 Modelled: 202 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: E: PDB Molecule:thymidylate synthase thyx; PDBTitle: crystal structure of flavin dependent thymidylate synthase thyx from2 helicobacter pylori complexed with fad and dump Phyre2 PDB 4p5a chain B Region: 4 - 233 Aligned: 207 Modelled: 215 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:thymidylate synthase thyx; PDBTitle: crystal structure of a ump/dump methylase polb from streptomyces2 cacaoi bound with 5-br ump Phyre2 PDB 2cfa chain B Region: 7 - 228 Aligned: 175 Modelled: 187 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: B: PDB Molecule:thymidylate synthase; PDBTitle: structure of viral flavin-dependant thymidylate synthase thyx Phyre2 PDB 3cux chain A Region: 85 - 101 Aligned: 17 Modelled: 17 Confidence: 25.2% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:malate synthase; PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design Phyre2 PDB 5ydf chain A Region: 175 - 206 Aligned: 32 Modelled: 32 Confidence: 19.1% Identity: 25% PDB header:transcription Chain: A: PDB Molecule:parafibromin; PDBTitle: crystal structure of a disease-related gene, hcdc73(1-100) Phyre2 PDB 3cuz chain A Region: 85 - 97 Aligned: 13 Modelled: 13 Confidence: 14.9% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:malate synthase a; PDBTitle: atomic resolution structures of escherichia coli and2 bacillis anthracis malate synthase a: comparison with3 isoform g and implications for structure based drug design Phyre2 PDB 2v7f chain A domain 1 Region: 199 - 226 Aligned: 28 Modelled: 28 Confidence: 14.0% Identity: 14% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Rps19E-like Phyre2 PDB 3mmi chain B Region: 184 - 230 Aligned: 47 Modelled: 47 Confidence: 12.8% Identity: 11% PDB header:motor protein Chain: B: PDB Molecule:myosin-4; PDBTitle: crystal structure of the globular tail of myo4p Phyre2 PDB 5vfb chain B Region: 85 - 100 Aligned: 16 Modelled: 16 Confidence: 12.0% Identity: 31% PDB header:transferase Chain: B: PDB Molecule:malate synthase g; PDBTitle: 1.36 angstrom resolution crystal structure of malate synthase g from2 pseudomonas aeruginosa in complex with glycolic acid. Phyre2 PDB 1nb5 chain I Region: 204 - 232 Aligned: 29 Modelled: 29 Confidence: 11.2% Identity: 21% Fold: Cystatin-like Superfamily: Cystatin/monellin Family: Cystatins Phyre2 PDB 4i1o chain D Region: 11 - 68 Aligned: 49 Modelled: 58 Confidence: 10.5% Identity: 16% PDB header:protein transport/hydrolase Chain: D: PDB Molecule:lepb; PDBTitle: crystal structure of the legionella pneumophila gap domain of lepb in2 complex with rab1b bound to gdp and bef3 Phyre2 PDB 3j21 chain A Region: 182 - 216 Aligned: 35 Modelled: 35 Confidence: 10.5% Identity: 9% PDB header:ribosome Chain: A: PDB Molecule:50s ribosomal protein l1p; PDBTitle: promiscuous behavior of proteins in archaeal ribosomes revealed by2 cryo-em: implications for evolution of eukaryotic ribosomes (50s3 ribosomal proteins) Phyre2 PDB 3mlq chain D Region: 79 - 95 Aligned: 17 Modelled: 17 Confidence: 9.8% Identity: 35% PDB header:transferase/transcription Chain: D: PDB Molecule:dna-directed rna polymerase subunit beta; PDBTitle: crystal structure of the thermus thermophilus transcription-repair2 coupling factor rna polymerase interacting domain with the thermus3 aquaticus rna polymerase beta1 domain Phyre2 PDB 5tpj chain A Region: 207 - 237 Aligned: 28 Modelled: 31 Confidence: 9.5% Identity: 32% PDB header:de novo protein Chain: A: PDB Molecule:denovo ntf2; PDBTitle: crystal structure of a de novo designed protein with curved beta-sheet Phyre2 PDB 5gyq chain A Region: 54 - 76 Aligned: 23 Modelled: 23 Confidence: 9.2% Identity: 17% PDB header:viral protein Chain: A: PDB Molecule:spike glycoprotein; PDBTitle: putative receptor-binding domain of bat-derived coronavirus hku9 spike2 protein Phyre2 PDB 2np3 chain A domain 1 Region: 36 - 44 Aligned: 9 Modelled: 9 Confidence: 8.8% Identity: 33% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: Tetracyclin repressor-like, N-terminal domain Phyre2 1 c2af6G_ 2 c3fnnA_ 3 c6j61B_ 4 d1o26a_ 5 c3ah5E_ 6 c4p5aB_ 7 c2cfaB_ 8 c3cuxA_ 9 c5ydfA_ 10 c3cuzA_ 11 d2v7fa1 12 c3mmiB_ 13 c5vfbB_ 14 d1nb5i_ 15 c4i1oD_ 16 c3j21a_ 17 c3mlqD_ 18 c5tpjA_ 19 c5gyqA_ 20 d2np3a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64