1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	R	V	E	K	V	E	K	V	R	L	G	D	H	L	D	F	S	N	G	H	T	S	G	H	T	S	P	A	S	E	P	G	G	R	Y	P	V	Y	G	A	N	G	V	I	G	Y	S	A	Q	H	N	A	R	G	P	L	I	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?												?		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	G	R	V	G	S	Y	C	G	S	L	R	Y	C	D	S	D	V	W	V	T	D	N	A	L	A	C	R	A	K	K	P	E	E	T	R	Y	W	Y	Y	A	L	L	G	F	G	L	N	R	Y	R	A	G	S	G	Q	P	L	L	S
Secondary structure
SS confidence
Disorder																																															?			?	?	?	?		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Q	G	V	L	R	N	V	S	V	S	A	V	A	A	P	D	R	P	R	I	G	E	I	L	G	A	F	D	D	K	I	A	A	N	D	R	V	I	E	A	A	E	A	L	M	L	A	I	V	G	R	L	S	A	Y	V	P	L	S	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	A	S	R	S	T	A	C	L	D	A	Q	H	F	D	S	T	V	A	H	Y	S	F	A	A	F	D	G	G	A	Q	P	S	R	V	G	G	R	T	I	R	S	A	K	L	V	V	S	Q	P	C	V	L	F	P	K	L	N	P	R
Secondary structure
SS confidence
Disorder									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	P	R	I	W	N	I	T	S	L	P	S	E	M	A	L	A	S	T	E	F	V	V	L	R	P	V	G	V	D	T	S	A	L	W	A	A	L	R	Q	P	D	V	L	A	E	L	R	Q	L	V	G	G	M	T	G	S	R	Q	R
Secondary structure
SS confidence
Disorder																																																				?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	Q	P	T	Q	L	L	R	V	W	V	R	D	V	R	R	L	T	P	G	H	A	A	A	I	A	N	L	G	A	L	C	N	E	R	R	I	E	S	A	R	L	A	S	C	R	D	A	L	L	P	L	L	M	S	G	I	D	G	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?		?		?	?																																													?	?	?
Disorder confidence
		.	.	.	.
Sequence		P	A	G	R
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 33%) Beta strand ( 26%)

Rank Aligned region

PDB 1yf2 chain A Region: 5 - 360 Aligned: 348 Modelled: 356 Confidence: 100.0% Identity: 16% PDB header:hydrolase regulator Chain: A: PDB Molecule:type i restriction-modification enzyme, s subunit; PDBTitle: three-dimensional structure of dna sequence specificity (s) subunit of2 a type i restriction-modification enzyme and its functional3 implications Phyre2 PDB 1ydx chain A Region: 2 - 357 Aligned: 348 Modelled: 355 Confidence: 100.0% Identity: 16% PDB header:dna binding protein Chain: A: PDB Molecule:type i restriction enzyme specificity protein mg438; PDBTitle: crystal structure of type-i restriction-modification system s subunit2 from m. genitalium Phyre2 PDB 2y7c chain A Region: 5 - 360 Aligned: 355 Modelled: 355 Confidence: 100.0% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:type-1 restriction enzyme ecoki specificity protein; PDBTitle: atomic model of the ocr-bound methylase complex from the type i2 restriction-modification enzyme ecoki (m2s1). based on fitting into3 em map 1534. Phyre2 PDB 3okg chain B Region: 5 - 358 Aligned: 340 Modelled: 352 Confidence: 100.0% Identity: 12% PDB header:dna binding protein Chain: B: PDB Molecule:restriction endonuclease s subunits; PDBTitle: crystal structure of hsds subunit from thermoanaerobacter2 tengcongensis Phyre2 PDB 1ydx chain A domain 2 Region: 4 - 175 Aligned: 170 Modelled: 172 Confidence: 100.0% Identity: 18% Fold: DNA methylase specificity domain Superfamily: DNA methylase specificity domain Family: Type I restriction modification DNA specificity domain Phyre2 PDB 1yf2 chain A domain 2 Region: 5 - 175 Aligned: 170 Modelled: 171 Confidence: 99.9% Identity: 16% Fold: DNA methylase specificity domain Superfamily: DNA methylase specificity domain Family: Type I restriction modification DNA specificity domain Phyre2 PDB 1ydx chain A domain 1 Region: 6 - 174 Aligned: 166 Modelled: 169 Confidence: 99.9% Identity: 19% Fold: DNA methylase specificity domain Superfamily: DNA methylase specificity domain Family: Type I restriction modification DNA specificity domain Phyre2 PDB 1yf2 chain A domain 1 Region: 5 - 175 Aligned: 170 Modelled: 171 Confidence: 99.9% Identity: 17% Fold: DNA methylase specificity domain Superfamily: DNA methylase specificity domain Family: Type I restriction modification DNA specificity domain Phyre2 PDB 1aqj chain B Region: 10 - 130 Aligned: 121 Modelled: 121 Confidence: 97.1% Identity: 13% PDB header:methyltransferase Chain: B: PDB Molecule:adenine-n6-dna-methyltransferase taqi; PDBTitle: structure of adenine-n6-dna-methyltransferase taqi Phyre2 PDB 1g38 chain A Region: 10 - 133 Aligned: 124 Modelled: 124 Confidence: 96.8% Identity: 13% PDB header:transferase/dna Chain: A: PDB Molecule:modification methylase taqi; PDBTitle: adenine-specific methyltransferase m. taq i/dna complex Phyre2 PDB 3s1s chain A Region: 53 - 180 Aligned: 127 Modelled: 128 Confidence: 93.3% Identity: 13% PDB header:hydrolase, transferase Chain: A: PDB Molecule:restriction endonuclease bpusi; PDBTitle: characterization and crystal structure of the type iig restriction2 endonuclease bpusi Phyre2 PDB 5hr4 chain J Region: 71 - 169 Aligned: 95 Modelled: 99 Confidence: 76.3% Identity: 13% PDB header:hydrolase/dna Chain: J: PDB Molecule:mmei; PDBTitle: structure of type iil restriction-modification enzyme mmei in complex2 with dna has implications for engineering of new specificities Phyre2 PDB 3bc1 chain F Region: 132 - 173 Aligned: 42 Modelled: 42 Confidence: 49.9% Identity: 12% PDB header:signaling protein/transport protein Chain: F: PDB Molecule:synaptotagmin-like protein 2; PDBTitle: crystal structure of the complex rab27a-slp2a Phyre2 PDB 1zke chain A domain 1 Region: 142 - 169 Aligned: 28 Modelled: 28 Confidence: 41.9% Identity: 7% Fold: ROP-like Superfamily: HP1531-like Family: HP1531-like Phyre2 PDB 5ihf chain A Region: 129 - 163 Aligned: 35 Modelled: 35 Confidence: 32.3% Identity: 20% PDB header:unknown function Chain: A: PDB Molecule:virg-like protein; PDBTitle: salmonella typhimurium virg-like (stv) protein Phyre2 PDB 4jkv chain A Region: 312 - 361 Aligned: 50 Modelled: 50 Confidence: 26.7% Identity: 20% PDB header:membrane protein Chain: A: PDB Molecule:soluble cytochrome b562, smoothened homolog; PDBTitle: structure of the human smoothened 7tm receptor in complex with an2 antitumor agent Phyre2 PDB 4ug1 chain A Region: 313 - 349 Aligned: 37 Modelled: 37 Confidence: 25.1% Identity: 11% PDB header:cell cycle Chain: A: PDB Molecule:cell cycle protein gpsb; PDBTitle: gpsb n-terminal domain Phyre2 PDB 6d80 chain A Region: 278 - 356 Aligned: 79 Modelled: 79 Confidence: 23.6% Identity: 6% PDB header:transport protein Chain: A: PDB Molecule:mitochondrial calcium uniporter; PDBTitle: cryo-em structure of the mitochondrial calcium uniporter from n.2 fischeri bound to saposin Phyre2 PDB 2lqt chain A Region: 125 - 147 Aligned: 23 Modelled: 23 Confidence: 22.5% Identity: 22% PDB header:unknown function Chain: A: PDB Molecule:coiled-coil-helix-coiled-coil-helix domain-containing PDBTitle: solution structure of chchd7 Phyre2 PDB 2ih2 chain A domain 2 Region: 198 - 309 Aligned: 111 Modelled: 112 Confidence: 21.5% Identity: 14% Fold: DNA methylase specificity domain Superfamily: DNA methylase specificity domain Family: TaqI C-terminal domain-like Phyre2 1 c1yf2A_ 2 c1ydxA_ 3 c2y7cA_ 4 c3okgB_ 5 d1ydxa2 6 d1yf2a2 7 d1ydxa1 8 d1yf2a1 9 c1aqjB_ 10 c1g38A_ 11 c3s1sA_ 12 c5hr4J_ 13 c3bc1F_ 14 d1zkea1 15 c5ihfA_ 16 c4jkvA_ 17 c4ug1A_ 18 c6d80A_ 19 c2lqtA_ 20 d2ih2a2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91