Phyre Home Retrieve Phyre Job Id
Emailmdejesus@rockefeller.edu
DescriptionRVBD2763c_(dfrA)_3073140_3073619
DateWed Aug 7 12:50:42 BST 2019
Unique Job IDc0509c7b4fe13fc6
SequenceMVGLIWAQAT ... Download FASTA
Job Typenormal
Job Expiry

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:36.219 Y:43.931 Z:44.777
Model (left) based on template d1df7a_
Top template information
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
Confidence and coverage
Confidence:100.0% Coverage:100%
159 residues (100% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
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Sequence analysis 

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Secondary structure and disorder prediction [Show] 

Domain analysis [Show] 

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#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1d1df7a_
100.0 100
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
2c6cxmA_
100.0 65
PDB header:oxidoreductase/inhibitor
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: crystal structure of a dihydrofolate reductase from mycobacterium2 smegmatis in complex with nadp and p218
3c4m7vA_
100.0 33
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: dihydrofolate reductase from enterococcus faecalis complexed with2 nadp(h)and rab-propyl
4c3tq8A_
100.0 36
PDB header:oxidoreductase/oxidoreductase inhibitor
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: structure of the dihydrofolate reductase (fola) from coxiella burnetii2 in complex with trimethoprim
5c3k2hA_
100.0 29
PDB header:transferase
Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase;
PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp
6c3f0uX_
100.0 27
PDB header:oxidoreductase
Chain: X: PDB Molecule:trimethoprim-sensitive dihydrofolate reductase;
PDBTitle: staphylococcus aureus f98y mutant dihydrofolate reductase complexed2 with nadph and 2,4-diamino-5-[3-(3-methoxy-5-phenylphenyl)but-1-3 ynyl]-6-methylpyrimidine
7c1zdrB_
100.0 34
PDB header:oxidoreductase
Chain: B: PDB Molecule:dihydrofolate reductase;
PDBTitle: dhfr from bacillus stearothermophilus
8c2oipE_
100.0 30
PDB header:transferase, oxidoreductase
Chain: E: PDB Molecule:chain a, crystal structure of dhfr;
PDBTitle: crystal structure of the s290g active site mutant of ts-dhfr from2 cryptosporidium hominis
9c4eckB_
100.0 32
PDB header:transferase, oxidoreductase
Chain: B: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate synthase;
PDBTitle: crystal structure of the toxoplasma gondii ts-dhfr
10d1ra9a_
100.0 36
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
11c3cseA_
100.0 33
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: candida glabrata dihydrofolate reductase complexed with nadph and 2,4-2 diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine3 (ucp120b)
12c3e0bA_
100.0 34
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: bacillus anthracis dihydrofolate reductase complexed with nadph and 2,2 4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine3 (ucp120b)
13c3ia5A_
100.0 35
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: moritella profunda dihydrofolate reductase (dhfr)
14c3vcoA_
100.0 32
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: schistosoma mansoni dihydrofolate reductase
15d2fzia1
100.0 34
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
16d3dfra_
100.0 33
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
17d1kmva_
100.0 34
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
18c3rg9A_
100.0 37
PDB header:oxidoreductase/oxidoreductase inhibitor
Chain: A: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate synthase;
PDBTitle: trypanosoma brucei dihydrofolate reductase (tbdhfr) in complex with2 wr99210
19d8dfra_
100.0 35
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
20c3jsuA_
100.0 28
PDB header:oxidoreductase, transferase
Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase;
PDBTitle: quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed3 with qn254, nadph, and dump
21d1j3ka_
not modelled 100.0 27
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
22c3dg8B_
not modelled 100.0 26
PDB header:oxidoreductase, transferase
Chain: B: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate synthase;
PDBTitle: quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed3 with rjf670, nadph, and dump
23c3ix9B_
not modelled 100.0 28
PDB header:oxidoreductase
Chain: B: PDB Molecule:dihydrofolate reductase;
PDBTitle: crystal structure of streptococcus pneumoniae dihydrofolate2 reductase - sp9 mutant
24c6drsA_
not modelled 100.0 41
PDB header:antifungal protein/inhibitor
Chain: A: PDB Molecule:dihydrofolate reductase, putative;
PDBTitle: dihydrofolate reductase (dhfr) of aspergillus flavus in complex with a2 small molecule inhibitor
25c2blcA_
not modelled 100.0 32
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase;
PDBTitle: sp21 double mutant p. vivax dihydrofolate reductase in complex with2 des-chloropyrimethamine
26d1aoea_
not modelled 100.0 29
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
27d1vdra_
not modelled 100.0 32
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
28c5eccA_
not modelled 100.0 29
PDB header:oxidoreductase/oxidoreductase inhibitor
Chain: A: PDB Molecule:dehydrofolate reductase type i;
PDBTitle: klebsiella pneumoniae dfra1 complexed with nadph and 6-ethyl-5-(3-(2-2 methoxy-5-(pyridin-4-yl)phenyl)prop-1-yn-1-yl)pyrimidine-2,4-diamine
29d1seja1
not modelled 100.0 30
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
30c3clbA_
not modelled 100.0 44
PDB header:oxidoreductase, transferase
Chain: A: PDB Molecule:dhfr-ts;
PDBTitle: structure of bifunctional tcdhfr-ts in complex with tmq
31d1juva_
not modelled 100.0 26
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
32d1d1ga_
not modelled 100.0 29
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:Dihydrofolate reductases
33c3jtwB_
not modelled 99.9 18
PDB header:oxidoreductase
Chain: B: PDB Molecule:dihydrofolate reductase;
PDBTitle: crystal structure of putative dihydrofolate reductase (yp_805003.1)2 from pediococcus pentosaceus atcc 25745 at 1.90 a resolution
34c2gd9A_
not modelled 99.9 18
PDB header:oxidoreductase
Chain: A: PDB Molecule:hypothetical protein yyap;
PDBTitle: crystal structure of a putative dihydrofolate reductase (bsu40760,2 yyap) from bacillus subtilis at 2.30 a resolution
35c2xw7A_
not modelled 99.8 20
PDB header:oxidoreductase
Chain: A: PDB Molecule:dihydrofolate reductase;
PDBTitle: structure of mycobacterium smegmatis putative reductase ms0308
36c3ky8B_
not modelled 99.7 23
PDB header:biosynthetic protein
Chain: B: PDB Molecule:putative riboflavin biosynthesis protein;
PDBTitle: crystal structure of putative riboflavin biosynthesis protein2 (yp_001092907.1) from shewanella sp. pv-4 at 2.12 a resolution
37c3kgyA_
not modelled 99.7 20
PDB header:oxidoreductase
Chain: A: PDB Molecule:bifunctional deaminase-reductase domain protein;
PDBTitle: crystal structure of putative dihydrofolate reductase (yp_001636057.1)2 from chloroflexus aurantiacus j-10-fl at 1.50 a resolution
38d2hxva1
not modelled 99.7 20
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:RibD C-terminal domain-like
39d2azna1
not modelled 99.6 14
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:RibD C-terminal domain-like
40d2b3za1
not modelled 99.5 17
Fold:Dihydrofolate reductase-like
Superfamily:Dihydrofolate reductase-like
Family:RibD C-terminal domain-like
41c2hxvA_
not modelled 99.5 19
PDB header:biosynthetic protein
Chain: A: PDB Molecule:diaminohydroxyphosphoribosylaminopyrimidine deaminase/ 5-
PDBTitle: crystal structure of a diaminohydroxyphosphoribosylaminopyrimidine2 deaminase/ 5-amino-6-(5-phosphoribosylamino)uracil reductase (tm1828)3 from thermotoga maritima at 1.80 a resolution
42c2d5nB_
not modelled 99.5 16
PDB header:hydrolase, oxidoreductase
Chain: B: PDB Molecule:riboflavin biosynthesis protein ribd;
PDBTitle: crystal structure of a bifunctional deaminase and reductase2 involved in riboflavin biosynthesis
43c5xuxC_
not modelled 99.4 18
PDB header:oxidoreductase
Chain: C: PDB Molecule:conserved protein;
PDBTitle: crystal structure of rib7 from methanosarcina mazei
44c2o7pA_
not modelled 99.4 15
PDB header:hydrolase, oxidoreductase
Chain: A: PDB Molecule:riboflavin biosynthesis protein ribd;
PDBTitle: the crystal structure of ribd from escherichia coli in complex with2 the oxidised nadp+ cofactor in the active site of the reductase3 domain
45c4xt6A_
not modelled 99.3 16
PDB header:oxidoreductase
Chain: A: PDB Molecule:rv2671;
PDBTitle: crystal structure of rv2671 from mycobacterium tuberculosis in complex2 with the tetrahydropteridine ring of tetrahydrofolate (thf)
46c3zpgA_
not modelled 99.2 15
PDB header:hydrolase
Chain: A: PDB Molecule:ribd;
PDBTitle: acinetobacter baumannii ribd, form 2
47c2p4gA_
not modelled 99.0 24
PDB header:oxidoreductase
Chain: A: PDB Molecule:hypothetical protein;
PDBTitle: crystal structure of a pyrimidine reductase-like protein (dip1392)2 from corynebacterium diphtheriae nctc at 2.30 a resolution
48c4ha7B_
not modelled 97.6 18
PDB header:oxidoreductase
Chain: B: PDB Molecule:2,5-diamino-6-ribosylamino-4(3h)-pyrimidinone 5'-phosphate
PDBTitle: structural insights into the reduction mechanism of saccharomyces2 cerevisia riboflavin biosynthesis reductase rib7
49c4jwjA_
not modelled 36.3 23
PDB header:transferase
Chain: A: PDB Molecule:trna (guanine(9)-n1)-methyltransferase;
PDBTitle: crystal structure of sctrm10(84)-sah complex
50c5nfjA_
not modelled 31.5 20
PDB header:transferase
Chain: A: PDB Molecule:mitochondrial ribonuclease p protein 1;
PDBTitle: crystal structure of the methyltransferase subunit of human2 mitochondrial ribonuclease p (mrpp1) bound to s-adenosyl-methionine3 (sam)
51c4fmwA_
not modelled 29.8 23
PDB header:transferase
Chain: A: PDB Molecule:rna (guanine-9-)-methyltransferase domain-containing
PDBTitle: crystal structure of methyltransferase domain of human rna (guanine-9-2 ) methyltransferase domain containing protein 2
52c4jwhB_
not modelled 27.9 23
PDB header:transferase
Chain: B: PDB Molecule:trna (guanine(9)-n1)-methyltransferase;
PDBTitle: crystal structure of sptrm10(full length)-sah complex
53c6emvA_
not modelled 19.7 20
PDB header:rna binding protein
Chain: A: PDB Molecule:trna (guanine(9)-/adenine(9)-n1)-methyltransferase;
PDBTitle: crystal structure of dual specific trm10 construct from thermococcus2 kodakaraensis.
54c5okzJ_
not modelled 14.9 29
PDB header:rna binding protein
Chain: J: PDB Molecule:m-phase phosphoprotein 6 homolog;
PDBTitle: crystal strucrure of the mpp6 exosome complex
55c4rflB_
not modelled 14.5 11
PDB header:oxidoreductase
Chain: B: PDB Molecule:glycerol-1-phosphate dehydrogenase [nad(p)+];
PDBTitle: crystal structure of g1pdh with nadph from methanocaldococcus2 jannaschii
56d1udxa3
not modelled 13.3 20
Fold:Obg GTP-binding protein C-terminal domain
Superfamily:Obg GTP-binding protein C-terminal domain
Family:Obg GTP-binding protein C-terminal domain
57c3ihtB_
not modelled 12.2 24
PDB header:transferase
Chain: B: PDB Molecule:s-adenosyl-l-methionine methyl transferase;
PDBTitle: crystal structure of s-adenosyl-l-methionine methyl transferase2 (yp_165822.1) from silicibacter pomeroyi dss-3 at 1.80 a resolution
58c6emsA_
not modelled 11.8 17
PDB header:rna binding protein
Chain: A: PDB Molecule:trna (guanine(9)-/adenine(9)-n1)-methyltransferase;
PDBTitle: crystal structure of dual specific trm10 construct from thermococcus2 kodakaraensis.
59d1xbra_
not modelled 11.4 14
Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily:p53-like transcription factors
Family:T-box
60c4cvkA_
not modelled 10.5 17
PDB header:ligase
Chain: A: PDB Molecule:udp-n-acetylmuramoyl-tripeptide--d-alanyl-d-alanine
PDBTitle: pamurf in complex with udp-murnac-tripeptide (mdap)
61d1h6fa_
not modelled 10.4 18
Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily:p53-like transcription factors
Family:T-box
62c2x6vB_
not modelled 10.2 16
PDB header:transcription/dna
Chain: B: PDB Molecule:t-box transcription factor tbx5;
PDBTitle: crystal structure of human tbx5 in the dna-bound and dna-2 free form
63c6q8iL_
not modelled 8.2 33
PDB header:splicing
Chain: L: PDB Molecule:protein red;
PDBTitle: nterminal domain of human smu1 in complex with human redmid
64c5vzjL_
not modelled 8.2 38
PDB header:hydrolase/rna
Chain: L: PDB Molecule:m-phase phosphoprotein 6 homolog;
PDBTitle: structure of a twelve component mpp6-nuclear rna exosome complex bound2 to rna
65c5t1jB_
not modelled 7.9 14
PDB header:transcription/dna
Chain: B: PDB Molecule:t-box transcription factor tbx21;
PDBTitle: crystal structure of the tbox dna binding domain of the transcription2 factor t-bet
66c3iuwA_
not modelled 7.9 17
PDB header:rna binding protein
Chain: A: PDB Molecule:activating signal cointegrator;
PDBTitle: crystal structure of activating signal cointegrator (np_814290.1) from2 enterococcus faecalis v583 at 1.58 a resolution
67d1q1ra2
not modelled 7.6 37
Fold:FAD/NAD(P)-binding domain
Superfamily:FAD/NAD(P)-binding domain
Family:FAD/NAD-linked reductases, N-terminal and central domains
68d1vjda_
not modelled 7.1 17
Fold:Phosphoglycerate kinase
Superfamily:Phosphoglycerate kinase
Family:Phosphoglycerate kinase
69c1kyqC_
not modelled 7.0 38
PDB header:oxidoreductase, lyase
Chain: C: PDB Molecule:siroheme biosynthesis protein met8;
PDBTitle: met8p: a bifunctional nad-dependent dehydrogenase and2 ferrochelatase involved in siroheme synthesis.
70c4ehjA_
not modelled 6.7 26
PDB header:transferase
Chain: A: PDB Molecule:phosphoglycerate kinase;
PDBTitle: an x-ray structure of a putative phosphogylcerate kinase from2 francisella tularensis subsp. tularensis schu s4
71c5a7yA_
not modelled 6.6 24
PDB header:transferase
Chain: A: PDB Molecule:trna (adenine(9)-n1)-methyltransferase;
PDBTitle: crystal structure of sulfolobus acidocaldarius trm10 in2 complex with s-adenosylhomocysteine
72c5fb3C_
not modelled 6.4 23
PDB header:oxidoreductase
Chain: C: PDB Molecule:glycerol-1-phosphate dehydrogenase [nad(p)+];
PDBTitle: structure of glycerophosphate dehydrogenase in complex with nadph
73d1kyqa1
not modelled 6.2 35
Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:Siroheme synthase N-terminal domain-like
74c6nm9A_
not modelled 6.0 50
PDB header:unknown function/rna
Chain: A: PDB Molecule:acrva4;
PDBTitle: cryoem structure of the lbcas12a-crrna-acrva4 dimer
75c3uhjE_
not modelled 5.7 27
PDB header:oxidoreductase
Chain: E: PDB Molecule:probable glycerol dehydrogenase;
PDBTitle: crystal structure of a probable glycerol dehydrogenase from2 sinorhizobium meliloti 1021
76c3hl0B_
not modelled 5.7 25
PDB header:oxidoreductase
Chain: B: PDB Molecule:maleylacetate reductase;
PDBTitle: crystal structure of maleylacetate reductase from agrobacterium2 tumefaciens
77d1hdia_
not modelled 5.6 17
Fold:Phosphoglycerate kinase
Superfamily:Phosphoglycerate kinase
Family:Phosphoglycerate kinase
78c4a04B_
not modelled 5.5 20
PDB header:transcription
Chain: B: PDB Molecule:t-box transcription factor tbx1;
PDBTitle: structure of the dna-bound t-box domain of human tbx1, a2 transcription factor associated with the digeorge syndrome
79c4y68A_
not modelled 5.5 12
PDB header:hydrolase
Chain: A: PDB Molecule:putative nisin-resistance protein;
PDBTitle: structure of a lipoprotein from streptococcus agalactiae
80c4ia6B_
not modelled 5.5 20
PDB header:immune system
Chain: B: PDB Molecule:myosin-crossreactive antigen;
PDBTitle: hydratase from lactobacillus acidophilus in a ligand bound form (la2 lah)
81c4c2dC_
not modelled 5.4 20
PDB header:hydrolase/peptide
Chain: C: PDB Molecule:carboxy-terminal processing protease ctpb;
PDBTitle: crystal structure of the protease ctpb in an active state
82c3dfzB_
not modelled 5.4 23
PDB header:oxidoreductase
Chain: B: PDB Molecule:precorrin-2 dehydrogenase;
PDBTitle: sirc, precorrin-2 dehydrogenase
83c3zlbA_
not modelled 5.3 26
PDB header:transferase
Chain: A: PDB Molecule:phosphoglycerate kinase;
PDBTitle: crystal structure of phosphoglycerate kinase from streptococcus2 pneumoniae
84c6oeeB_
not modelled 5.3 19
PDB header:translocase
Chain: B: PDB Molecule:type iv secretion system apparatus protein cagt;
PDBTitle: structure of cagt from a cryo-em reconstruction of a t4ss
85c1zmrA_
not modelled 5.3 26
PDB header:transferase
Chain: A: PDB Molecule:phosphoglycerate kinase;
PDBTitle: crystal structure of the e. coli phosphoglycerate kinase
86d1qpga_
not modelled 5.1 17
Fold:Phosphoglycerate kinase
Superfamily:Phosphoglycerate kinase
Family:Phosphoglycerate kinase

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