Phyre Home Retrieve Phyre Job Id
Emailmdejesus@rockefeller.edu
DescriptionRVBD2764c_(thyA)_3073690_3074481
DateWed Aug 7 12:50:42 BST 2019
Unique Job ID798e61c333cd64c3
SequenceVTPYEDLLRF ... Download FASTA
Job Typenormal
Job Expiry

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:51.942 Y:54.545 Z:43.887
Model (left) based on template c2oipE_
Top template information
PDB header:transferase, oxidoreductase
Chain: E: PDB Molecule:chain a, crystal structure of dhfr;
PDBTitle: crystal structure of the s290g active site mutant of ts-dhfr from2 cryptosporidium hominis
Confidence and coverage
Confidence:100.0% Coverage:100%
262 residues (100% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
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Sequence analysis 

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Secondary structure and disorder prediction [Show] 

Domain analysis [Show] 

Detailed template information [Hide] 

 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2oipE_
100.0 48
PDB header:transferase, oxidoreductase
Chain: E: PDB Molecule:chain a, crystal structure of dhfr;
PDBTitle: crystal structure of the s290g active site mutant of ts-dhfr from2 cryptosporidium hominis
2c4eckB_
100.0 50
PDB header:transferase, oxidoreductase
Chain: B: PDB Molecule:bifunctional dihydrofolate reductase-thymidylate synthase;
PDBTitle: crystal structure of the toxoplasma gondii ts-dhfr
3d1qzfa2
100.0 49
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
4d1j3kc_
100.0 45
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
5c3jsuA_
100.0 45
PDB header:oxidoreductase, transferase
Chain: A: PDB Molecule:dihydrofolate reductase-thymidylate synthase;
PDBTitle: quadruple mutant(n51i+c59r+s108n+i164l) plasmodium falciparum2 dihydrofolate reductase-thymidylate synthase(pfdhfr-ts) complexed3 with qn254, nadph, and dump
6c3qj7D_
100.0 98
PDB header:transferase
Chain: D: PDB Molecule:thymidylate synthase;
PDBTitle: crystal structure of the mycobacterium tuberculosis thymidylate2 synthase (thya) bound to dump
7c3k2hA_
100.0 50
PDB header:transferase
Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase;
PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp
8d1tswa_
100.0 61
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
9d2g8oa1
100.0 66
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
10c3clbA_
100.0 49
PDB header:oxidoreductase, transferase
Chain: A: PDB Molecule:dhfr-ts;
PDBTitle: structure of bifunctional tcdhfr-ts in complex with tmq
11d1hvya_
100.0 54
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
12d1seja2
100.0 49
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
13c4dq1A_
100.0 59
PDB header:transferase
Chain: A: PDB Molecule:thymidylate synthase;
PDBTitle: thymidylate synthase from staphylococcus aureus.
14c2aazG_
100.0 48
PDB header:transferase
Chain: G: PDB Molecule:thymidylate synthase;
PDBTitle: cryptococcus neoformans thymidylate synthase complexed with substrate2 and an antifolate
15d1f28a_
100.0 48
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
16c4iswB_
100.0 49
PDB header:transferase
Chain: B: PDB Molecule:thymidylate synthase;
PDBTitle: crystal structure of phosphorylated c.elegans thymidylate synthase in2 complex with dump
17d2tsra_
100.0 53
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
18d1bkpa_
100.0 37
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
19c4g9uD_
100.0 51
PDB header:transferase
Chain: D: PDB Molecule:thymidylate synthase;
PDBTitle: crystal structure of trichinella spiralis thymidylate synthase2 complexed with dump
20d1tisa_
100.0 50
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
21c3v8hB_
not modelled 100.0 39
PDB header:transferase
Chain: B: PDB Molecule:thymidylate synthase;
PDBTitle: crystal structure of thymidylate synthase from burkholderia2 thailandensis
22c6aujC_
not modelled 100.0 61
PDB header:transferase
Chain: C: PDB Molecule:thymidylate synthase;
PDBTitle: crystal structure of thymidylate synthase from elizabethkingia2 anophelis nuhp1
23c1hw3A_
not modelled 100.0 54
PDB header:transferase
Chain: A: PDB Molecule:thymidylate synthase;
PDBTitle: structure of human thymidylate synthase suggests advantages of2 chemotherapy with noncompetitive inhibitors
24c1hw4A_
not modelled 100.0 54
PDB header:transferase
Chain: A: PDB Molecule:thymidylate synthase;
PDBTitle: structure of thymidylate synthase suggests advantages of chemotherapy2 with noncompetitive inhibitors
25c3ix6B_
not modelled 100.0 63
PDB header:transferase
Chain: B: PDB Molecule:thymidylate synthase;
PDBTitle: crystal structure of thymidylate synthase thya from brucella2 melitensis
26c3kgbA_
not modelled 100.0 51
PDB header:transferase
Chain: A: PDB Molecule:thymidylate synthase 1/2;
PDBTitle: crystal structure of thymidylate synthase 1/2 from encephalitozoon2 cuniculi at 2.2 a resolution
27c3egyX_
not modelled 100.0 55
PDB header:transferase
Chain: X: PDB Molecule:thymidylate synthase;
PDBTitle: crystal structure of human thymidyalte synthase a191k with loop 181-2 197 stabilized in the inactive conformation
28c5b6dB_
not modelled 100.0 23
PDB header:transferase
Chain: B: PDB Molecule:cmp 5-hydroxymethylase;
PDBTitle: crystal structure of cytidine monophosphate hydroxymethylase mila with2 cmp
29d1b5ea_
not modelled 100.0 24
Fold:Thymidylate synthase/dCMP hydroxymethylase
Superfamily:Thymidylate synthase/dCMP hydroxymethylase
Family:Thymidylate synthase/dCMP hydroxymethylase
30c2vsvB_
not modelled 45.7 16
PDB header:protein binding
Chain: B: PDB Molecule:rhophilin-2;
PDBTitle: crystal structure of the pdz domain of human rhophilin-2
31c1w9qB_
not modelled 30.4 14
PDB header:cell adhesion
Chain: B: PDB Molecule:syntenin 1;
PDBTitle: crystal structure of the pdz tandem of human syntenin in complex with2 tnefaf peptide
32d1ueza_
not modelled 30.4 22
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
33c3khfA_
not modelled 27.1 22
PDB header:transferase
Chain: A: PDB Molecule:microtubule-associated serine/threonine-protein kinase 3;
PDBTitle: the crystal structure of the pdz domain of human microtubule2 associated serine/threonine kinase 3 (mast3)
34c6irdC_
not modelled 25.6 19
PDB header:hydrolase/protein binding
Chain: C: PDB Molecule:inad-like protein;
PDBTitle: complex structure of inadl pdz89 and plcb4 c-terminal cc-pbm
35c4rhoA_
not modelled 25.2 15
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of a hypothetical protein (bpsl2088) from2 burkholderia pseudomallei k96243 at 2.25 a resolution
36c6nmgB_
not modelled 24.6 22
PDB header:signaling protein
Chain: B: PDB Molecule:resistance to inhibitors of cholinesterase 8 homolog a (c.
PDBTitle: crystal structure of rat ric-8a g alpha binding domain
37d1vaea_
not modelled 24.4 18
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
38c4qhwA_
not modelled 23.3 28
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of a putative two-domain sugar hydrolase2 (baccac_02064) from bacteroides caccae atcc 43185 at 1.35 a3 resolution
39c3diwB_
not modelled 21.4 24
PDB header:signaling protein/cell adhesion
Chain: B: PDB Molecule:tax1-binding protein 3;
PDBTitle: c-terminal beta-catenin bound tip-1 structure
40c2kv8A_
not modelled 21.3 15
PDB header:signaling protein
Chain: A: PDB Molecule:regulator of g-protein signaling 12;
PDBTitle: solution structure ofrgs12 pdz domain
41c2q3gA_
not modelled 19.7 20
PDB header:structural genomics
Chain: A: PDB Molecule:pdz and lim domain protein 7;
PDBTitle: structure of the pdz domain of human pdlim7 bound to a c-2 terminal extension from human beta-tropomyosin
42d1fc6a3
not modelled 19.6 23
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:Tail specific protease PDZ domain
43c6jdpA_
not modelled 19.3 25
PDB header:antitoxin
Chain: A: PDB Molecule:imm52 family protein;
PDBTitle: the imm52 family protein tsit (pa3908) from pseudomonas aeruginosa
44d1w9ea1
not modelled 19.2 11
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
45c4rgwB_
not modelled 18.5 28
PDB header:transferase/transcription
Chain: B: PDB Molecule:transcription initiation factor tfiid subunit 7;
PDBTitle: crystal structure of a taf1-taf7 complex in human transcription factor2 iid
46c3o46A_
not modelled 17.9 15
PDB header:protein binding
Chain: A: PDB Molecule:maguk p55 subfamily member 7;
PDBTitle: crystal structure of the pdz domain of mpp7
47d2byga1
not modelled 17.4 18
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
48d1y7na1
not modelled 17.2 22
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
49c3j39I_
not modelled 17.0 19
PDB header:ribosome
Chain: I: PDB Molecule:60s ribosomal protein l10;
PDBTitle: structure of the d. melanogaster 60s ribosomal proteins
50c3shuB_
not modelled 16.5 28
PDB header:cell adhesion
Chain: B: PDB Molecule:tight junction protein zo-1;
PDBTitle: crystal structure of zo-1 pdz3
51c2eeiA_
not modelled 15.8 17
PDB header:metal binding protein
Chain: A: PDB Molecule:pdz domain-containing protein 1;
PDBTitle: solution structure of second pdz domain of pdz domain2 containing protein 1
52d1wi4a1
not modelled 14.6 13
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
53c2jikB_
not modelled 14.6 16
PDB header:membrane protein
Chain: B: PDB Molecule:synaptojanin-2 binding protein;
PDBTitle: crystal structure of pdz domain of synaptojanin-2 binding2 protein
54d1nowa1
not modelled 14.5 29
Fold:TIM beta/alpha-barrel
Superfamily:(Trans)glycosidases
Family:beta-N-acetylhexosaminidase catalytic domain
55d1ihja_
not modelled 14.2 19
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
56c3qglD_
not modelled 13.5 19
PDB header:protein binding
Chain: D: PDB Molecule:sorting nexin-27;
PDBTitle: crystal structure of pdz domain of sorting nexin 27 (snx27) in complex2 with the eseskv peptide corresponding to the c-terminal tail of girk3
57d1jt6a1
not modelled 13.1 13
Fold:DNA/RNA-binding 3-helical bundle
Superfamily:Homeodomain-like
Family:Tetracyclin repressor-like, N-terminal domain
58c2gzvA_
not modelled 13.1 19
PDB header:signaling protein
Chain: A: PDB Molecule:prkca-binding protein;
PDBTitle: the cystal structure of the pdz domain of human pick1
59d2o7ta1
not modelled 12.8 24
Fold:DNA/RNA-binding 3-helical bundle
Superfamily:Homeodomain-like
Family:Tetracyclin repressor-like, N-terminal domain
60c2ejyA_
not modelled 12.7 20
PDB header:membrane protein
Chain: A: PDB Molecule:55 kda erythrocyte membrane protein;
PDBTitle: solution structure of the p55 pdz t85c domain complexed2 with the glycophorin c f127c peptide
61c5oarB_
not modelled 12.7 13
PDB header:hydrolase
Chain: B: PDB Molecule:beta-hexosaminidase;
PDBTitle: crystal structure of native beta-n-acetylhexosaminidase isolated from2 aspergillus oryzae
62c2z17A_
not modelled 12.7 19
PDB header:protein binding
Chain: A: PDB Molecule:pleckstrin homology sec7 and coiled-coil domains-
PDBTitle: crystal sturcture of pdz domain from human pleckstrin2 homology, sec7
63c1u3bA_
not modelled 12.6 22
PDB header:protein transport
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding,
PDBTitle: auto-inhibition mechanism of x11s/mints family scaffold2 proteins revealed by the closed conformation of the tandem3 pdz domains
64c3l4fD_
not modelled 12.5 22
PDB header:signaling protein/protein binding
Chain: D: PDB Molecule:sh3 and multiple ankyrin repeat domains protein 1;
PDBTitle: crystal structure of betapix coiled-coil domain and shank pdz complex
65c2v90E_
not modelled 12.3 14
PDB header:protein binding
Chain: E: PDB Molecule:pdz domain-containing protein 3;
PDBTitle: crystal structure of the 3rd pdz domain of intestine- and kidney-2 enriched pdz domain ikepp (pdzd3)
66c6gbeA_
not modelled 12.3 22
PDB header:protein binding
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 13;
PDBTitle: murine protein tyrosine phosphatase ptpn13 pdz3 domain-prk2 peptide2 complex
67d1r6ja_
not modelled 12.0 22
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
68c1r6jA_
not modelled 12.0 22
PDB header:membrane protein
Chain: A: PDB Molecule:syntenin 1;
PDBTitle: ultrahigh resolution crystal structure of syntenin pdz2
69c1nteA_
not modelled 12.0 22
PDB header:signaling protein
Chain: A: PDB Molecule:syntenin 1;
PDBTitle: crystal structure analysis of the second pdz domain of syntenin
70c2eehA_
not modelled 11.8 24
PDB header:metal binding protein
Chain: A: PDB Molecule:pdz domain-containing protein 7;
PDBTitle: solution structure of first pdz domain of pdz domain2 containing protein 7
71c3zf7K_
not modelled 11.5 13
PDB header:ribosome
Chain: K: PDB Molecule:60s ribosomal protein l10, putative;
PDBTitle: high-resolution cryo-electron microscopy structure of the trypanosoma2 brucei ribosome
72c2dm8A_
not modelled 11.3 25
PDB header:protein binding
Chain: A: PDB Molecule:inad-like protein;
PDBTitle: solution structure of the eighth pdz domain of human inad-2 like protein
73d2fcfa1
not modelled 11.2 24
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
74d1uita_
not modelled 11.2 24
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
75d1q3oa_
not modelled 10.6 22
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
76c5yf4A_
not modelled 10.6 21
PDB header:protein binding
Chain: A: PDB Molecule:mob-like protein phocein;
PDBTitle: a kinase complex mst4-mob4
77c2fneB_
not modelled 10.6 22
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:multiple pdz domain protein;
PDBTitle: the crystal structure of the 13th pdz domain of mpdz
78d1jaka1
not modelled 10.5 23
Fold:TIM beta/alpha-barrel
Superfamily:(Trans)glycosidases
Family:beta-N-acetylhexosaminidase catalytic domain
79d1wifa_
not modelled 10.3 19
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
80d2f5ya1
not modelled 10.3 14
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
81c4lqqB_
not modelled 10.3 29
PDB header:transferase/transferase activator
Chain: B: PDB Molecule:cbk1 kinase activator protein mob2;
PDBTitle: crystal structure of the cbk1(t743e)-mob2 kinase-coactivator complex2 in crystal form b
82d1u3ba2
not modelled 10.2 22
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
83d1pi1a_
not modelled 10.2 38
Fold:Bromodomain-like
Superfamily:Mob1/phocein
Family:Mob1/phocein
84d1t2ma1
not modelled 10.2 16
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
85c3rcnA_
not modelled 10.2 16
PDB header:hydrolase
Chain: A: PDB Molecule:beta-n-acetylhexosaminidase;
PDBTitle: crystal structure of beta-n-acetylhexosaminidase from arthrobacter2 aurescens
86c2ka9A_
not modelled 9.9 20
PDB header:cell adhesion
Chain: A: PDB Molecule:disks large homolog 4;
PDBTitle: solution structure of psd-95 pdz12 complexed with cypin2 peptide
87d1p1da2
not modelled 9.9 15
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
88c2yuyA_
not modelled 9.8 22
PDB header:signaling protein
Chain: A: PDB Molecule:rho gtpase activating protein 21;
PDBTitle: solution structure of pdz domain of rho gtpase activating2 protein 21
89c3qikA_
not modelled 9.6 25
PDB header:hydrolase regulator
Chain: A: PDB Molecule:phosphatidylinositol 3,4,5-trisphosphate-dependent rac
PDBTitle: crystal structure of the first pdz domain of prex1
90c4a8aI_
not modelled 9.6 32
PDB header:hydrolase/hydrolase
Chain: I: PDB Molecule:periplasmic ph-dependent serine endoprotease degq;
PDBTitle: asymmetric cryo-em reconstruction of e. coli degq 12-mer in complex2 with lysozyme
91c2d92A_
not modelled 9.5 18
PDB header:protein binding
Chain: A: PDB Molecule:inad-like protein;
PDBTitle: solution structure of the fifth pdz domain of inad-like2 protein
92c1m04A_
not modelled 9.4 19
PDB header:hydrolase
Chain: A: PDB Molecule:beta-n-acetylhexosaminidase;
PDBTitle: mutant streptomyces plicatus beta-hexosaminidase (d313n) in complex2 with product (glcnac)
93d1whaa_
not modelled 9.3 19
Fold:PDZ domain-like
Superfamily:PDZ domain-like
Family:PDZ domain
94d2gjxa1
not modelled 9.0 16
Fold:TIM beta/alpha-barrel
Superfamily:(Trans)glycosidases
Family:beta-N-acetylhexosaminidase catalytic domain
95c1obyA_
not modelled 8.9 22
PDB header:cell adhesion
Chain: A: PDB Molecule:syntenin 1;
PDBTitle: crystal structure of the complex of pdz2 of syntenin with a syndecan-42 peptide.
96c4tkzA_
not modelled 8.9 58
PDB header:transferase
Chain: A: PDB Molecule:putative uncharacterized protein gbs1890;
PDBTitle: crystal structure of phosphotransferase system component eiia from2 streptococcus agalactiae
97c2hjnA_
not modelled 8.9 31
PDB header:cell cycle
Chain: A: PDB Molecule:maintenance of ploidy protein mob1;
PDBTitle: structural and functional analysis of saccharomyces2 cerevisiae mob1
98c6ezrA_
not modelled 8.7 19
PDB header:hydrolase
Chain: A: PDB Molecule:beta-n-acetylglucosaminidase nag2;
PDBTitle: crystal structure of gh20 exo beta-n-acetylglucosaminidase from vibrio2 harveyi
99c1u39A_
not modelled 8.7 22
PDB header:protein transport
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding,
PDBTitle: auto-inhibition mechanism of x11s/mints family scaffold2 proteins revealed by the closed conformation of the tandem3 pdz domains

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