1

.

.

.

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.

.

.

.

10

.

.

.

.

.

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20

.

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30

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40

.

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50

.

.

.

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.

.

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.

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60

Sequence

M

V

G

Y

E

G

A

R

G

R

A

G

R

E

M

S

E

S

A

T

A

G

A

R

S

S

R

I

P

F

G

I

I

R

N

H

E

A

V

R

P

R

R

S

R

H

L

N

H

A

R

D

T

P

Q

M

V

A

V

A

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

.

.

.

.

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.

.

.

.

80

.

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.

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.

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90

.

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.

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.

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.

.

.

100

.

.

.

.

.

.

.

.

.

110

.

.

.

.

.

.

.

Sequence

Q

V

W

R

E

V

V

Q

A

T

A

I

A

I

A

P

P

L

P

V

V

S

W

G

L

I

S

L

A

F

L

S

H

T

V

R

G

R

Y

R

R

S

P

P

A

E

S

G

H

H

S

N

R

R

Q

A

K

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 51%) Alpha helix ( 75%) Beta strand ( 0%)

Rank Aligned region

PDB 1hyo chain A domain 1 Region: 28 - 42 Aligned: 15 Modelled: 15 Confidence: 16.4% Identity: 27% Fold: SH3-like barrel Superfamily: Fumarylacetoacetate hydrolase, FAH, N-terminal domain Family: Fumarylacetoacetate hydrolase, FAH, N-terminal domain Phyre2 PDB 4z8v chain A Region: 76 - 108 Aligned: 33 Modelled: 33 Confidence: 12.8% Identity: 42% PDB header:protein binding Chain: A: PDB Molecule:avrrxo1-orf1; PDBTitle: crystal structure of avrrxo1-orf1:-orf2 complex, native. Phyre2 PDB 1qa4 chain A Region: 94 - 108 Aligned: 15 Modelled: 15 Confidence: 12.3% Identity: 53% PDB header:viral protein Chain: A: PDB Molecule:protein (hiv-1 nef anchor domain (2-57)); PDBTitle: hiv-1 nef anchor domain, nmr, 2 structures Phyre2 PDB 2y0n chain E Region: 72 - 84 Aligned: 13 Modelled: 13 Confidence: 9.6% Identity: 54% PDB header:transcription Chain: E: PDB Molecule:male-specific lethal 1 homolog; PDBTitle: crystal structure of the complex between dosage2 compensation factors msl1 and msl3 Phyre2 PDB 1zec chain A Region: 94 - 105 Aligned: 12 Modelled: 12 Confidence: 9.1% Identity: 58% PDB header:viral peptide Chain: A: PDB Molecule:nef1-25; PDBTitle: nmr solution structure of nef1-25, 20 structures Phyre2 PDB 1v6t chain A Region: 52 - 76 Aligned: 25 Modelled: 25 Confidence: 8.3% Identity: 28% Fold: 7-stranded beta/alpha barrel Superfamily: Glycoside hydrolase/deacetylase Family: LamB/YcsF-like Phyre2 PDB 3ixz chain B Region: 82 - 91 Aligned: 10 Modelled: 10 Confidence: 7.8% Identity: 40% PDB header:hydrolase Chain: B: PDB Molecule:potassium-transporting atpase subunit beta; PDBTitle: pig gastric h+/k+-atpase complexed with aluminium fluoride Phyre2 PDB 5ujr chain A Region: 63 - 68 Aligned: 6 Modelled: 6 Confidence: 7.7% Identity: 83% PDB header:antimicrobial protein Chain: A: PDB Molecule:bacteriocin; PDBTitle: nmr solution structure of the two-component bacteriocin cbnxy Phyre2 PDB 2y0n chain G Region: 74 - 84 Aligned: 11 Modelled: 11 Confidence: 7.6% Identity: 64% PDB header:transcription Chain: G: PDB Molecule:male-specific lethal 1 homolog; PDBTitle: crystal structure of the complex between dosage2 compensation factors msl1 and msl3 Phyre2 PDB 2y0n chain H Region: 74 - 84 Aligned: 11 Modelled: 11 Confidence: 7.6% Identity: 64% PDB header:transcription Chain: H: PDB Molecule:male-specific lethal 1 homolog; PDBTitle: crystal structure of the complex between dosage2 compensation factors msl1 and msl3 Phyre2 PDB 3b8e chain B Region: 82 - 91 Aligned: 10 Modelled: 10 Confidence: 6.3% Identity: 40% PDB header:hydrolase/transport protein Chain: B: PDB Molecule:sodium/potassium-transporting atpase subunit PDBTitle: crystal structure of the sodium-potassium pump Phyre2 PDB 1s21 chain A Region: 32 - 49 Aligned: 18 Modelled: 18 Confidence: 5.8% Identity: 22% PDB header:chaperone Chain: A: PDB Molecule:orf2; PDBTitle: crystal structure of avrpphf orf2, a type iii effector from p.2 syringae Phyre2 PDB 1s21 chain A Region: 32 - 49 Aligned: 18 Modelled: 18 Confidence: 5.8% Identity: 22% Fold: ADP-ribosylation Superfamily: ADP-ribosylation Family: AvrPphF ORF2, a type III effector Phyre2 1 d1hyoa1 2 c4z8vA_ 3 c1qa4A_ 4 c2y0nE_ 5 c1zecA_ 6 d1v6ta_ 7 c3ixzB_ 8 c5ujrA_ 9 c2y0nG_ 10 c2y0nH_ 11 c3b8eB_ 12 c1s21A_ 13 d1s21a_